Long Term Exercise in Humans Reduces Markers of Cellular Senescence in Intestinal Tissue

In this study, researchers show that long-term exercise does reduce signs of cellular senescence in this tissue, though this appears to be a matter of reducing the proportion of the study population exhibiting high biomarker values rather than moving the average for everyone. Whether this outcome is similar in other tissues is an open question. While exercise is beneficial, one can't exercise one's way out from under degenerative aging, only somewhat slow its progression. Regular endurance exercise training is an effective intervention for the maintenance of metabolic health and the prevention of many age-associated chronic diseases. Several metabolic and inflammatory factors are involved in the health-promoting effects of exercise training, but regulatory mechanisms remain poorly understood. Cellular senescence - a state of irreversible growth arrest - is considered a basic mechanism of aging. Senescent cells accumulate over time and promote a variety of age-related pathologies from neurodegenerative disorders to cancer. Whether long-term intensive exercise training affect the accumulation of age-associated cellular senescence is still unclear. Here, we show that the classical senescence markers p16 and IL-6 were markedly higher in the colon mucosa of middle-aged and older overweight adults than in young sedentary individuals, but this upregulation was significantly blunted in age-matched endurance runners. Interestingly, we observe a linear correlation betwe...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs