iPLA2 inhibition blocks LysoPC-induced TRPC6 externalization and promotes Re-endothelialization of carotid injuries in hypercholesterolemic mice

This study suggests that iPLA2 is a potential therapeutic target to attenuate calcium influx through TRPC6 channels and promote EC healing in cardiovascular patients undergoing angioplasty.PMID:37030190 | DOI:10.1016/j.ceca.2023.102734

Source: Cell Calcium - April 8, 2023 Category: Cytology Authors: Priya Putta Pinaki Chaudhuri Rocio Guardia-Wolff Michael A Rosenbaum Linda M Graham Source Type: research