GAS-STING signaling plays an essential pathogenetic role in Doxorubicin-Induced Cardiotoxicity

CONCLUSION: This research premise established that STING inhibition could alleviate Dox-triggered cardiotoxicity in mice. As a result, preventing DIC by repressing STING in cardiomyocytes might be a possible treatment approach.PMID:36964634 | PMC:PMC10037834 | DOI:10.1186/s40360-022-00631-0

Source: BMC Pharmacology and Toxicology - March 25, 2023 Category: Drugs & Pharmacology Authors: Zilong Xiao Ziqing Yu Chaofeng Chen Ruizhen Chen Yangang Su Source Type: research