Possible Mechanisms of the Neuroprotective Actions of Date Palm Fruits Aqueous Extracts against Valproic Acid-Induced Autism in Rats

Conclusions: AFE administration might improve the autistic-like symptoms induced by VPA in rats via attenuation of the oxidative stress, upregulation of Nrf2 and HO-1, Sirt-1 and LC3 expression with downregulation of caspase-3, and NFκB expression in the cerebellum and hippocampus.PMID:36826050 | PMC:PMC9954972 | DOI:10.3390/cimb45020105

Source: Current Issues in Molecular Biology - February 24, 2023 Category: Molecular Biology Authors: Abdelaziz M Hussein Seham Ahmed Mahmoud Khalid Mohammed Elazab Ahmed F Abouelnaga Marwa Abass Ahmed A H Mosa Mennatullah A M Hussein Mohamed E G Elsayed Source Type: research