Brain-derived neurotrophic factor and neuroimaging in pediatric patients with sickle cell disease

CONCLUSION: Serum BDNF levels were higher in sickle disease patients who had abnormal transcranial Doppler. BDNF had a significant diagnostic ability in the detection of SCD complications.IMPACT: Silent stroke is a very serious complication in children with sickle cell disease, so regular follow up should be every six months. BDNF is considered a potential biomarker for stroke risk prediction in patients unable to receive TCD.PMID:36774398 | DOI:10.1038/s41390-023-02513-5

Source: Pediatric Research - February 11, 2023 Category: Pediatrics Authors: Asmaa A Mahmoud Sameh A Abd El Naby Ahmed S Abdelgawad Marwa Sabry Rizq Nahla M S Abd El Hady Source Type: research