Cancers, Vol. 15, Pages 730: Is Reflex Germline BRCA1/2 Testing Necessary in Women Diagnosed with Non-Mucinous High-Grade Epithelial Ovarian Cancer Aged 80 Years or Older?

Cancers, Vol. 15, Pages 730: Is Reflex Germline BRCA1/2 Testing Necessary in Women Diagnosed with Non-Mucinous High-Grade Epithelial Ovarian Cancer Aged 80 Years or Older? Cancers doi: 10.3390/cancers15030730 Authors: Robert D. Morgan George J. Burghel Nicola Flaum Michael Bulman Philip Smith Andrew R. Clamp Jurjees Hasan Claire L. Mitchell Zena Salih Emma R. Woodward Fiona Lalloo Emma J. Crosbie Richard J. Edmondson Helene Schlecht Gordon C. Jayson D. Gareth R. Evans Women diagnosed with non-mucinous high-grade epithelial ovarian cancer (EOC) in England are often reflex-tested for germline and tumour BRCA1/2 variants. The value of germline BRCA1/2 testing in women diagnosed aged ≥80 is questionable. We performed an observational study of all women diagnosed with non-mucinous high-grade EOC who underwent germline and tumour BRCA1/2 testing by the North West of England Genomic Laboratory Hub. A subgroup of women also underwent germline testing using a panel of homologous recombination repair (HRR) genes and/or tumour testing for homologous recombination deficiency (HRD) using Myriad’s myChoice® companion diagnostic. Seven-hundred-two patients successfully underwent both germline and tumour BRCA1/2 testing. Of these, 48 were diagnosed with non-mucinous high-grade EOC aged ≥80. In this age group, somatic BRCA1/2 pathogenic/likely pathogenic variants (PV/LPVs) were detected nine times more often...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research