Significance of cardiovascular comorbidity in patients with chronic myelomonocytic leukemia

SummaryIn a  retrospective study, we analyzed the prevalence of common cardiovascular comorbidities in 310 patients with chronic myelomonocytic leukemia (CMML), their potential prognostic impact, and potential correlations with laboratory and molecular features. 115 (36%) patients had a documented cardiovasc ular comorbidity. In these patients, coronary heart disease 41/115 (36%), atrial fibrillation 34/115 (29%), and hypertension 75/115 (64%) were documented. None of these conditions had a significant impact on survival. Unexpectedly, patients with cardiovascular comorbidity had a lower number of cir culating blasts and a lower prevalence ofEZH2 mutations. Moreover, time to transformation was significantly longer in these patients. Cardiovascular comorbidity does not seem to have a  major impact on prognosis in CMML patients. The unexpected lower transformation rate in these patients needs to be further investigated.
Source: Wiener Medizinische Wochenschrift - Category: General Medicine Source Type: research