What is PT-INR monitoring? Cardiology Basics
What is PT-INR monitoring? Cardiology Basics
INR is short for International Normalized Ratio of Prothrombin Time. It is also called PT-INR. The INR monitoring is used to monitor the dosage of vitamin K antagonists like warfarin. Vitamin K antagonists are used for stroke prevention in atrial fibrillation as well as for deep vein thrombosis and pulmonary embolism. Non vitamin K oral anticoagulants (NOACs), also known as direct oral anticoagulants (DOACs) like dabigatran, rivaroxaban and apixaban do not need INR monitoring. Warfarin is routinely used when there is a mechanical prosthetic valve, to prevent valve thrombosis and thromboembolism. As of now, DOACs are not ideal for mechanical prosthetic valves as they have a higher thrombogenicity.
The target range of INR values needed depend on the indication for using it. In most cases the target INR value is 2-3. If the value obtained in the test while on medication is higher, the dose of the medication is reduced and vice versa. In certain cases, as with a mechanical prosthetic mitral valve, a higher INR value of 2.5 to 3.5 is recommended. In general, prosthetic valves at mitral position have a higher thrombotic risk. Newer types of aortic mechanical prosthetic valves with an INR goal of 1.5-2.5 with low dose aspirin, after the initial 3 months are also available [1].
Several other medications and foods interfere with the action of coumadin or warfarin. Highly protein bound medications displace warfarin from plasma proteins and i...
Source: Cardiophile MD - Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
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