Molecules, Vol. 27, Pages 6253: From cis-Lobeline to trans-Lobeline: Study on the Pharmacodynamics and Isomerization Factors

This study reports a new discovery. Despite the widespread use of ventilators, first-aid medicines such as nikethamide and lobeline has retired to second line, but as a nonselective antagonist with high affinity for a4b2 and a3b2 nicotinic acetylcholine receptors (nAChRs). In recent years, lobeline has shown great promise as a therapeutic drug for mental addiction and nervous system disorders, such as depression, Alzheimer disease and Parkinson disease. Therefore, we suggest that the differences between two isomers should be concerned in subsequent research papers and applications.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research