The Evolving Landscape of Primary Biliary Cholangitis

Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by the destruction of intrahepatic bile ductules, resulting in chronic cholestasis, that can progress to advanced fibrosis, cirrhosis, portal hypertension, and hepatocellular carcinoma (HCC), and if untreated, requires liver transplantation. Ursodeoxycholic acid (UDCA) has been an effective first-line agent for this condition for approximately three decades; however, approximately one-third of patients are not complete responders to UDCA.
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Tags: Preface Source Type: research