Using the Peripheral Nervous System as a Source of Cells for Central Nervous System Regeneration

It is in principle possible to obtain cells from the peripheral nervous system that may, once cultured and expanded in number, and possibly altered in their behavior via the application of suitable signal molecules, produce regeneration in the brain or other portions of the central nervous system. The peripheral nervous system is more readily accessed than the central nervous system, and this is the big point in favor of searching the periphery of the body for cells that might be useful in areas of the more protected, less accessible inner body. With a steadily aging population there is an increasing prevalence of neurological disorders. Given the lack of effective treatment strategies and a limited ability for the central nervous system (CNS) to regenerate endogenously, there is a critical need to better understand exogenous strategies for nervous system repair. Stem cell therapy offers a promising approach to promote the repair of neurologic tissue and function, however studies to date have been limited by various factors including challenges in harvesting donor cells from the CNS, ethical concerns regarding use of embryonic or fetal tissue, tumorigenic potential of induced pluripotent stem cells, and immune-mediated rejection of non-autologous cell sources. Here we review and propose two alternative sources of autologous cells derived from the peripheral nervous system (PNS) for CNS repair: enteric neuronal stem cells (ENSCs) and neural crest-derived Schwan...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs