Interrupting synoviolin play at the ER: a plausible action to elevate mitochondrial energetics and silence obesity

Obesity is a global concern, which has been linked to increased risk for cardiovascular disease, type 2 diabetes, atherosclerosis, non-alcoholic fatty liver, and cancer. In this issue of The EMBO Journal, Fujita et al (2015) describe the role of an endoplasmic reticulum (ER)-resident E3 ubiquitin ligase, synoviolin, and its ability to control body weight and energy expenditure by targeting PGC-1β, a transcriptional modulator of mitochondrial oxidative metabolism.

Source: EMBO Journal - April 15, 2015 Category: Molecular Biology Authors: Soustek, M. S., Puigserver, P. Tags: Metabolism, Post-translational Modifications, Proteolysis & Proteomics Have you seen? Source Type: research