Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

ConclusionsAbnormal histone hyperacetylation facilitates DNA damage in steatotic hepatocytes and is a potential initiating event in hepatocellular carcinogenesis.

http://link.springer.com/10.1186/s13073-022-01071-5

Source: Genome Medicine - June 23, 2022 Category: Genetics & Stem Cells Source Type: research