[Retracted] Upregulation of microRNA ‑181b inhibits CCL18‑induced breast cancer cell metastasis and invasion via the NF‑κB signaling pathway
Oncol Lett. 2024 Apr 15;27(6):268. doi: 10.3892/ol.2024.14401. eCollection 2024 Jun.ABSTRACT[This retracts the article DOI: 10.3892/ol.2016.5230.].PMID:38659419 | PMC:PMC11040538 | DOI:10.3892/ol.2024.14401 (Source: Oncology Letters)
Source: Oncology Letters - April 25, 2024 Category: Cancer & Oncology Authors: Lei Wang Yu-Xia Wang Li-Ping Chen Ming-Li Ji Source Type: research
Bioinformatics analysis and experimental verification of NLRX1 as a prognostic factor for esophageal squamous cell carcinoma
Oncol Lett. 2024 Apr 11;27(6):264. doi: 10.3892/ol.2024.14397. eCollection 2024 Jun.ABSTRACTNucleotide binding and oligomeric domain-like receptor X1 (NLRX1), a member of the NLR family, is associated with the physiological and pathological processes of inflammation, autophagy, immunity, metabolism and mitochondrial regulation, and has been demonstrated to have pro- or antitumor effects in various tumor types. However, the biological function of NLRX1 in esophageal squamous cell carcinoma (ESCC) has remained elusive. In the present study, by using bioinformatics methods, the differential expression of NLRX1 at the mRNA lev...
Source: Oncology Letters - April 25, 2024 Category: Cancer & Oncology Authors: Lu Zhou Lanlan Gan Chen Sun Alan Chu Menglin Yang Zongwen Liu Source Type: research
Precision CT ‑guided marking with India ink and microcoils for laparoscopic resection of a lateral lymph node recurrence of rectal cancer: A case report
Oncol Lett. 2024 Apr 12;27(6):266. doi: 10.3892/ol.2024.14399. eCollection 2024 Jun.ABSTRACTAlthough rarely used in laparoscopic surgery, computed tomography (CT)-guided marking is useful for targeting small lesions. The present study describes the performance of laparoscopic resection with preoperative CT-guided marking for lateral lymph node recurrence of rectal cancer. A 48-year-old man underwent laparoscopic low anterior resection with D3 lymph node dissection for rectal cancer (postoperative diagnosis, stage IIIb). Postoperative adjuvant chemotherapy was then administered. Solitary lymph node recurrence was observed i...
Source: Oncology Letters - April 25, 2024 Category: Cancer & Oncology Authors: Shunsuke Furukawa Masatsugu Hiraki Takeshi Oda Yukihiko Takahashi Ryuichiro Samejima Source Type: research
Lenvatinib ‑based treatment regimens in conversion therapy of unresectable hepatocellular carcinoma: A systematic review and meta‑analysis
Oncol Lett. 2024 Apr 12;27(6):265. doi: 10.3892/ol.2024.14398. eCollection 2024 Jun.ABSTRACTHepatocellular carcinoma (HCC) is a malignancy associated with high morbidity and mortality rates. Conversion therapy provides patients with unresectable HCC (uHCC) the opportunity to undergo radical treatment and achieve long-term survival. Despite accumulating evidence regarding the efficacy of conversion therapy, the optimal treatment approach for such therapy remains uncertain. Lenvatinib (LEN) has shown efficacy and tolerable rates of adverse events (AEs) when applied in combination with immune checkpoint inhibitors (ICIs) or l...
Source: Oncology Letters - April 25, 2024 Category: Cancer & Oncology Authors: Saixin Li Zeyu Zhang Zheng Wang Kenan Wang Minghao Sui Dongbin Liu Kuo Liang Source Type: research
Perfusion drugs for non ‑muscle invasive bladder cancer (Review)
Oncol Lett. 2024 Apr 15;27(6):267. doi: 10.3892/ol.2024.14400. eCollection 2024 Jun.ABSTRACTThe high recurrence rate and poor prognosis of non-muscle invasive bladder cancer (BC) are challenges that need to be urgently addressed. Transurethral cystectomy for bladder tumors is often combined with bladder perfusion therapy, which can effectively reduce the recurrence and progression rates of BC. The present review integrated and analyzed currently available bladder perfusion drugs, mainly including chemotherapeutic agents, immunotherapeutic agents and other adjuvant perfusion drugs. Bacillus Calmette-Guerin (BCG) perfusion w...
Source: Oncology Letters - April 25, 2024 Category: Cancer & Oncology Authors: Jingyuan Qian Qiuchen Zhang Yang Cao Xi Chu Yiyang Gao Haifei Xu Hongzhou Cai Jiajia Wu Source Type: research
Primary anastomosing hemangioma as a preoperative diagnostic mimicker of retroperitoneal cavernous hemangioma: A case report
Oncol Lett. 2024 Apr 9;27(6):254. doi: 10.3892/ol.2024.14386. eCollection 2024 Jun.ABSTRACTAnastomosing hemangioma (AH) is rare and a newly recognized variant of capillary hemangioma that is mostly found in the genitourinary tract. Additionally, AH is sometimes difficult to diagnose without pathological specimens. It is difficult to diagnose preoperatively due to the lack of specific clinical and radiologic appearance. The present report describes the imaging features from a radiological perspective and outlines the clinicopathologic features and treatment options. A 67-year-old woman was referred to Dokkyo Medical Univers...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Hirotaka Ishido Hidehiro Tajima Soya Meguro Musashi Takada Teppei Tatsuoka Keishi Kawasaki Yuko Ono Shinichi Ban Takashi Okuyama Hideyuki Yoshitomi Source Type: research
Clinical significance of the CXCL8/CXCR1/R2 signalling axis in patients with invasive breast cancer
Oncol Lett. 2024 Apr 10;27(6):260. doi: 10.3892/ol.2024.14393. eCollection 2024 Jun.ABSTRACTThe C-X-C motif chemokine ligand 8 (CXCL8)-C-X-C chemokine receptor (CXCR)1/2 signalling axis is among numerous mechanisms which stimulate the immune system to defend against tumour growth and influence the tumour microenvironment to promote tumour growth. This pathway plays an important role in the development of a number of cancers including breast cancer (BC). The aim of the present study was to analyse the levels of the chemokine CXCL8 and its receptors, CXCR1 and CXCR2, in the serum of female patients with invasive BC and to as...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Sebastian St ępień Marta Smycz-Kuba ńska Celina Kruszniewska-Rajs Joanna Magdalena Gola Jacek Kabut Pawe ł Olczyk Aleksandra Mielczarek-Palacz Source Type: research
Clinical prognostic significance of xeroderma pigmentosum group C and IFN ‑γ in non‑small cell lung cancer
Oncol Lett. 2024 Apr 9;27(6):259. doi: 10.3892/ol.2024.14392. eCollection 2024 Jun.ABSTRACTLung cancer is the most common cancer in the world due to its high incidence and recurrence. Genetic instability is one of the main factors leading to its occurrence, development and poor prognosis. Decreased xeroderma pigmentosum group C (XPC) expression notably enhances the stem cell properties of lung cancer cells and increases their proliferation and migration. Additionally, patients with lung cancer and low XPC expression had a poor prognosis. The purpose of the present study was to analyze the effect of XPC and IFN-γ on the cl...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Yongming Wang Weiyu Wang Huaijie Wang Liya Qin Meijia Zhang Yong Zhang Yubing Wang Changcheng Hao Meihua Qu Gongchao Wang Source Type: research
Non ‑coding RNA: A promising diagnostic biomarker and therapeutic target for esophageal squamous cell carcinoma (Review)
Oncol Lett. 2024 Apr 9;27(6):255. doi: 10.3892/ol.2024.14388. eCollection 2024 Jun.ABSTRACTEsophageal cancer (EC) is a common form of malignant tumor in the digestive system that is classified into two types: Esophageal squamous cell carcinomas (ESCC) and esophageal adenocarcinoma. ESCC is known for its early onset of symptoms, which can be difficult to identify, as well as its rapid progression and tendency to develop drug resistance to chemotherapy and radiotherapy. These factors contribute to the high incidence of disease and low cure rate. Therefore, a diagnostic biomarker and therapeutic target need to be identified f...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Longze Zhang Yanyang Wang Jianmei Gao Xue Zhou Minglei Huang Xianyao Wang Zhixu He Source Type: research
Rare retroperitoneal giant sacral schwannoma: A case report
Oncol Lett. 2024 Apr 10;27(6):261. doi: 10.3892/ol.2024.14394. eCollection 2024 Jun.ABSTRACTSchwannomas localized in the sacrum are relatively infrequent, accounting for 1-5% of all spinal axis schwannomas; they present with vague symptoms or are symptomless, so often grow to a considerable size before detection. Sacral schwannomas occasionally present with enormous dimensions, and these tumors are termed giant sacral schwannomas. However, their surgical removal is challenging owing to an abundant vascularity. The present study retrospectively analyzed the clinical and follow-up data of a patient with a giant sacral schwan...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Shunchang Zhou Shenyi Wan Liang Li Wei Dong Xuhui Ma Haibo Chu Yuxu Zhong Source Type: research
Pan ‑immune‑inflammation value as a novel prognostic biomarker in nasopharyngeal carcinoma
In conclusion, the PIV was a powerful predictor of survival outcomes and outperformed the SII in patients with NPC treated with chemoradiotherapy. Prospective validation of the PIV should be performed to better stratify radical treatment of patients with NPC.PMID:38646495 | PMC:PMC11027095 | DOI:10.3892/ol.2024.14385 (Source: Oncology Letters)
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Zhen Su Jie Tang Yan He Wei Hua Zeng Qian Yu Xiao Long Cao Guo Rong Zou Source Type: research
MicroRNA ‑1224 inhibits cell proliferation by downregulating CBX3 expression in chordoma
Oncol Lett. 2024 Apr 10;27(6):262. doi: 10.3892/ol.2024.14395. eCollection 2024 Jun.ABSTRACTMicroRNAs (miRNAs/miRs) have abnormal expression in numerous tumors and are closely related to tumor development and resistance to radiotherapy and chemotherapy. However, there are few studies assessing the role and mechanism of miRNA in chordoma. The sequencing data of three pairs of chordoma and notochord tissues from the GSE56183 dataset were analyzed in the present study. Cell proliferation was assessed in vitro using Cell Counting Kit-8. Bioinformatics analysis and the dual luciferase reporter assay were used to evaluate the re...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Wei Xia Jihe Huang Chunhua Sun Fei Shen Kejia Yang Source Type: research
The numerous facets of 1q21 < sup > + < /sup > in multiple myeloma: Pathogenesis, clinicopathological features, prognosis and clinical progress (Review)
Oncol Lett. 2024 Apr 9;27(6):258. doi: 10.3892/ol.2024.14391. eCollection 2024 Jun.ABSTRACTMultiple myeloma (MM) is a malignant neoplasm characterized by the clonal proliferation of abnormal plasma cells (PCs) in the bone marrow and recurrent cytogenetic abnormalities. The incidence of MM worldwide is on the rise. 1q21+ has been found in ~30-40% of newly diagnosed MM (NDMM) patients.1q21+ is associated with the pathophysiological mechanisms of disease progression and drug resistance in MM. In the present review, the pathogenesis and clinicopathological features of MM patients with 1q21+ were studied, the key data of 1q21+ ...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Na Liu Zhanzhi Xie Hao Li Luqun Wang Source Type: research
Metastatic breast cancer with double heterozygosity for the < em > BRCA1 < /em > and < em > BRCA2 < /em > genes responding to olaparib: A case report
In conclusion, the present study reported a female patient with double heterozygosity of BRCA1 and BRCA2 who benefited from olaparib monotherapy. Thus, olaparib may be a suitable treatment for such patients.PMID:38646498 | PMC:PMC11027096 | DOI:10.3892/ol.2024.14387 (Source: Oncology Letters)
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Bin Shao Lijun Di Source Type: research
Advances in molecular mechanisms of inflammatory bowel disease ‑associated colorectal cancer (Review)
Oncol Lett. 2024 Apr 9;27(6):257. doi: 10.3892/ol.2024.14390. eCollection 2024 Jun.ABSTRACTThe link between inflammation and cancer is well documented and colonic inflammation caused by inflammatory bowel disease (IBD) is thought to be a high-risk factor for the development of colorectal cancer (CRC). The complex crosstalk between epithelial and inflammatory cells is thought to underlie the progression from inflammation to cancer. The present review collates and summarises recent advances in the understanding of the pathogenesis of IBD-associated CRC (IBD-CRC), including the oncogenic mechanisms of the main inflammatory si...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Zhi Wang Yu Chang Haibo Sun Yuqin Li Tongyu Tang Source Type: research
