The numerous facets of 1q21 < sup > + < /sup > in multiple myeloma: Pathogenesis, clinicopathological features, prognosis and clinical progress (Review)

Oncol Lett. 2024 Apr 9;27(6):258. doi: 10.3892/ol.2024.14391. eCollection 2024 Jun.ABSTRACTMultiple myeloma (MM) is a malignant neoplasm characterized by the clonal proliferation of abnormal plasma cells (PCs) in the bone marrow and recurrent cytogenetic abnormalities. The incidence of MM worldwide is on the rise. 1q21+ has been found in ~30-40% of newly diagnosed MM (NDMM) patients.1q21+ is associated with the pathophysiological mechanisms of disease progression and drug resistance in MM. In the present review, the pathogenesis and clinicopathological features of MM patients with 1q21+ were studied, the key data of 1q21+ on the prognosis of MM patients were summarized, and the clinical treatment significance of MM patients with 1q21+ was clarified, in order to provide reference for clinicians to develop treatment strategies targeting 1q21+.PMID:38646497 | PMC:PMC11027100 | DOI:10.3892/ol.2024.14391
Source: Oncology Letters - Category: Cancer & Oncology Authors: Source Type: research