An intricate regulatory circuit between FLI1 and GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic differentiation
Mol Med Rep. 2024 Jun;29(6):107. doi: 10.3892/mmr.2024.13231. Epub 2024 May 2.ABSTRACTDuring hematopoiesis, megakaryocytic erythroid progenitors (MEPs) differentiate into megakaryocytic or erythroid lineages in response to specific transcriptional factors, yet the regulatory mechanism remains to be elucidated. Using the MEP‑like cell line HEL western blotting, RT‑qPCR, lentivirus‑mediated downregulation, flow cytometry as well as chromatin immunoprecipitation (ChIp) assay demonstrated that the E26 transformation‑specific (ETS) transcription factor friend leukemia integration factor 1 (Fli‑1) inhibits erythroid di...
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Chunlin Wang Maoting Hu Kunlin Yu Wuling Liu Anling Hu Yi Kuang Lei Huang Babu Gajendran Eldad Zacksenhaus Xiao Xiao Yaacov Ben-David Source Type: research
Genetic analysis of seven patients with inherited ichthyosis and Nagashima ‑type palmoplantar keratoderma
In conclusion, a clear genetic differential diagnosis was made for the enrolled ichthyosis‑associated patients; the study findings also extended the mutation spectrum of ichthyosis and provided solid evidence for the counseling of the affected families.PMID:38695247 | DOI:10.3892/mmr.2024.13235 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Jing Zhang Yue Yao Ya Tan Hua-Ying Hu Lin-Xi Zeng Guo-Qiang Zhang Source Type: research
Calcitonin gene ‑related peptide alleviates hyperoxia‑induced human alveolar cell injury via the CGRPR/TRPV1/Ca2 < sup > + < /sup > axis
In conclusion, exogenous CGRP acted by inversely regulating the function of TRPV1 channels in alveolar cells. Importantly, CGRP protected alveolar cells from hyperoxia‑induced injury via the CGRPR/TRPV1/Ca2+ axis, which may be a potential target for the prevention and treatment of the HILI.PMID:38695251 | DOI:10.3892/mmr.2024.13234 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Jun-Hui Li Han-Xing Wan Li-Hong Wu Fang Fang Jian-Xin Wang Hui Dong Feng Xu Source Type: research
Pancreatic stellate cells: Key players in pancreatic health and diseases (Review)
Mol Med Rep. 2024 Jul;30(1):109. doi: 10.3892/mmr.2024.13233. Epub 2024 May 2.ABSTRACTAs a pluripotent cell, activated pancreatic stellate cells (PSCs) can differentiate into various pancreatic parenchymal cells and participate in the secretion of extracellular matrix and the repair of pancreatic damage. Additionally, PSCs characteristics allow them to contribute to pancreatic inflammation and carcinogenesis. Moreover, a detailed study of the pathogenesis of activated PSCs in pancreatic disease can offer promise for the development of innovative therapeutic strategies and improved patient prognoses. Therefore, the present ...
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Zhengfeng Wang Shi Dong Wence Zhou Source Type: research
[Retracted] LncRNA TUG1 serves an important role in hypoxia ‑induced myocardial cell injury by regulating the miR‑145‑5p‑Binp3 axis
Mol Med Rep. 2024 Jul;30(1):108. doi: 10.3892/mmr.2024.13232. Epub 2024 May 2.ABSTRACTFollowing the publication of this article, a concerned reader drew to the Editor's attention that, for several of the figures showing the results of Transwell migration and invasion assay experiments, unexpected areas of similarity were identified in terms of cellular patterns comparing among data panels where the results from differently performed experiments were intended to have been shown, although the areas immediately surrounding these areas often featured comparatively different distributions of cells. Moreover, several of the figu...
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Zhongwei Wu Shengji Zhao Chunfu Li Chaoquan Liu Source Type: research
An intricate regulatory circuit between FLI1 and GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic differentiation
Mol Med Rep. 2024 Jun;29(6):107. doi: 10.3892/mmr.2024.13231. Epub 2024 May 2.ABSTRACTDuring hematopoiesis, megakaryocytic erythroid progenitors (MEPs) differentiate into megakaryocytic or erythroid lineages in response to specific transcriptional factors, yet the regulatory mechanism remains to be elucidated. Using the MEP‑like cell line HEL western blotting, RT‑qPCR, lentivirus‑mediated downregulation, flow cytometry as well as chromatin immunoprecipitation (ChIp) assay demonstrated that the E26 transformation‑specific (ETS) transcription factor friend leukemia integration factor 1 (Fli‑1) inhibits erythroid di...
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Chunlin Wang Maoting Hu Kunlin Yu Wuling Liu Anling Hu Yi Kuang Lei Huang Babu Gajendran Eldad Zacksenhaus Xiao Xiao Yaacov Ben-David Source Type: research
Genetic analysis of seven patients with inherited ichthyosis and Nagashima ‑type palmoplantar keratoderma
In conclusion, a clear genetic differential diagnosis was made for the enrolled ichthyosis‑associated patients; the study findings also extended the mutation spectrum of ichthyosis and provided solid evidence for the counseling of the affected families.PMID:38695247 | DOI:10.3892/mmr.2024.13235 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Jing Zhang Yue Yao Ya Tan Hua-Ying Hu Lin-Xi Zeng Guo-Qiang Zhang Source Type: research
Calcitonin gene ‑related peptide alleviates hyperoxia‑induced human alveolar cell injury via the CGRPR/TRPV1/Ca2 < sup > + < /sup > axis
In conclusion, exogenous CGRP acted by inversely regulating the function of TRPV1 channels in alveolar cells. Importantly, CGRP protected alveolar cells from hyperoxia‑induced injury via the CGRPR/TRPV1/Ca2+ axis, which may be a potential target for the prevention and treatment of the HILI.PMID:38695251 | DOI:10.3892/mmr.2024.13234 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Jun-Hui Li Han-Xing Wan Li-Hong Wu Fang Fang Jian-Xin Wang Hui Dong Feng Xu Source Type: research
Pancreatic stellate cells: Key players in pancreatic health and diseases (Review)
Mol Med Rep. 2024 Jul;30(1):109. doi: 10.3892/mmr.2024.13233. Epub 2024 May 2.ABSTRACTAs a pluripotent cell, activated pancreatic stellate cells (PSCs) can differentiate into various pancreatic parenchymal cells and participate in the secretion of extracellular matrix and the repair of pancreatic damage. Additionally, PSCs characteristics allow them to contribute to pancreatic inflammation and carcinogenesis. Moreover, a detailed study of the pathogenesis of activated PSCs in pancreatic disease can offer promise for the development of innovative therapeutic strategies and improved patient prognoses. Therefore, the present ...
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Zhengfeng Wang Shi Dong Wence Zhou Source Type: research
[Retracted] LncRNA TUG1 serves an important role in hypoxia ‑induced myocardial cell injury by regulating the miR‑145‑5p‑Binp3 axis
Mol Med Rep. 2024 Jul;30(1):108. doi: 10.3892/mmr.2024.13232. Epub 2024 May 2.ABSTRACTFollowing the publication of this article, a concerned reader drew to the Editor's attention that, for several of the figures showing the results of Transwell migration and invasion assay experiments, unexpected areas of similarity were identified in terms of cellular patterns comparing among data panels where the results from differently performed experiments were intended to have been shown, although the areas immediately surrounding these areas often featured comparatively different distributions of cells. Moreover, several of the figu...
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Zhongwei Wu Shengji Zhao Chunfu Li Chaoquan Liu Source Type: research
An intricate regulatory circuit between FLI1 and GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic differentiation
Mol Med Rep. 2024 Jun;29(6):107. doi: 10.3892/mmr.2024.13231. Epub 2024 May 2.ABSTRACTDuring hematopoiesis, megakaryocytic erythroid progenitors (MEPs) differentiate into megakaryocytic or erythroid lineages in response to specific transcriptional factors, yet the regulatory mechanism remains to be elucidated. Using the MEP‑like cell line HEL western blotting, RT‑qPCR, lentivirus‑mediated downregulation, flow cytometry as well as chromatin immunoprecipitation (ChIp) assay demonstrated that the E26 transformation‑specific (ETS) transcription factor friend leukemia integration factor 1 (Fli‑1) inhibits erythroid di...
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Chunlin Wang Maoting Hu Kunlin Yu Wuling Liu Anling Hu Yi Kuang Lei Huang Babu Gajendran Eldad Zacksenhaus Xiao Xiao Yaacov Ben-David Source Type: research
Genetic analysis of seven patients with inherited ichthyosis and Nagashima ‑type palmoplantar keratoderma
In conclusion, a clear genetic differential diagnosis was made for the enrolled ichthyosis‑associated patients; the study findings also extended the mutation spectrum of ichthyosis and provided solid evidence for the counseling of the affected families.PMID:38695247 | DOI:10.3892/mmr.2024.13235 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Jing Zhang Yue Yao Ya Tan Hua-Ying Hu Lin-Xi Zeng Guo-Qiang Zhang Source Type: research
Calcitonin gene ‑related peptide alleviates hyperoxia‑induced human alveolar cell injury via the CGRPR/TRPV1/Ca2 < sup > + < /sup > axis
In conclusion, exogenous CGRP acted by inversely regulating the function of TRPV1 channels in alveolar cells. Importantly, CGRP protected alveolar cells from hyperoxia‑induced injury via the CGRPR/TRPV1/Ca2+ axis, which may be a potential target for the prevention and treatment of the HILI.PMID:38695251 | DOI:10.3892/mmr.2024.13234 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Jun-Hui Li Han-Xing Wan Li-Hong Wu Fang Fang Jian-Xin Wang Hui Dong Feng Xu Source Type: research
Pancreatic stellate cells: Key players in pancreatic health and diseases (Review)
Mol Med Rep. 2024 Jul;30(1):109. doi: 10.3892/mmr.2024.13233. Epub 2024 May 2.ABSTRACTAs a pluripotent cell, activated pancreatic stellate cells (PSCs) can differentiate into various pancreatic parenchymal cells and participate in the secretion of extracellular matrix and the repair of pancreatic damage. Additionally, PSCs characteristics allow them to contribute to pancreatic inflammation and carcinogenesis. Moreover, a detailed study of the pathogenesis of activated PSCs in pancreatic disease can offer promise for the development of innovative therapeutic strategies and improved patient prognoses. Therefore, the present ...
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Zhengfeng Wang Shi Dong Wence Zhou Source Type: research
[Retracted] LncRNA TUG1 serves an important role in hypoxia ‑induced myocardial cell injury by regulating the miR‑145‑5p‑Binp3 axis
Mol Med Rep. 2024 Jul;30(1):108. doi: 10.3892/mmr.2024.13232. Epub 2024 May 2.ABSTRACTFollowing the publication of this article, a concerned reader drew to the Editor's attention that, for several of the figures showing the results of Transwell migration and invasion assay experiments, unexpected areas of similarity were identified in terms of cellular patterns comparing among data panels where the results from differently performed experiments were intended to have been shown, although the areas immediately surrounding these areas often featured comparatively different distributions of cells. Moreover, several of the figu...
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Zhongwei Wu Shengji Zhao Chunfu Li Chaoquan Liu Source Type: research
