Pancreatic stellate cells: Key players in pancreatic health and diseases (Review)

Mol Med Rep. 2024 Jul;30(1):109. doi: 10.3892/mmr.2024.13233. Epub 2024 May 2.ABSTRACTAs a pluripotent cell, activated pancreatic stellate cells (PSCs) can differentiate into various pancreatic parenchymal cells and participate in the secretion of extracellular matrix and the repair of pancreatic damage. Additionally, PSCs characteristics allow them to contribute to pancreatic inflammation and carcinogenesis. Moreover, a detailed study of the pathogenesis of activated PSCs in pancreatic disease can offer promise for the development of innovative therapeutic strategies and improved patient prognoses. Therefore, the present study review aimed to examine the involvement of activated PSCs in pancreatic diseases and elucidate the underlying mechanisms to provide a viable therapeutic strategy for the management of pancreas‑related diseases.PMID:38695254 | DOI:10.3892/mmr.2024.13233
Source: Molecular Medicine Reports - Category: Molecular Biology Authors: Source Type: research