CD226 promotes renal fibrosis by regulating macrophage activation and migration
J Leukoc Biol. 2024 Apr 25:qiae054. doi: 10.1093/jleuko/qiae054. Online ahead of print.ABSTRACTIt has been found that CD226 plays an important role in regulating macrophage function, but its expression and function in macrophages during renal fibrogenesis have not been studied. Our data demonstrated that CD226 expression in macrophages was obviously upregulated in the unilateral ureteral obstruction model, while CD226 deficiency attenuated collagen deposition in renal interstitium along with fewer M1 within renal cortex and renal medulla and a lower level of proinflammatory factors compared to that of control littermates. ...
Source: Journal of Leukocyte Biology - April 25, 2024 Category: Hematology Authors: Yun Song Yazhen Wang Juan Li Yuting Shen Yongli Hou Zhaoyue Fu Liang Fang Boquan Jin Lihua Chen Source Type: research
N6-Methyladenosine Promotes TNF mRNA Degradation In CD4+ T Lymphocytes
J Leukoc Biol. 2024 Apr 24:qiae087. doi: 10.1093/jleuko/qiae087. Online ahead of print.ABSTRACTN6-methyladenosine (m6A) is a RNA modification that can regulate post-transcriptional processes including RNA stability, translation, splicing and nuclear export. In CD4+ lymphocytes, m6A modifications have been demonstrated to play a role in early differentiation processes. The role of m6A in CD4+ T cell activation and effector function remains incompletely understood. To assess the role of m6A in CD4+ T lymphocyte activation and function, we assessed the transcriptome-wide m6A landscape of human primary CD4+ T cells by methylat...
Source: Journal of Leukocyte Biology - April 24, 2024 Category: Hematology Authors: Ellen C N van Vroonhoven Lucas W Picavet Rianne C Scholman Lyanne J P M Sijbers Corlinda R E Kievit Noortje A M van den Dungen Michal Mokry Anouk Evers Robert J Lebbink Enric Mocholi Paul J Coffer Jorg J A Calis Sebastiaan J Vastert Jorg van Loosdregt Source Type: research
Lack of mTORC2 signalling in CD11c+ myeloid cells inhibits their migration and ameliorates experimental colitis
J Leukoc Biol. 2024 Apr 23:qiae084. doi: 10.1093/jleuko/qiae084. Online ahead of print.ABSTRACTThe Mammalian Target of Rapamycin (mTOR) pathway plays a key role in determining immune cells function through modulation of their metabolic status. By specific deletion of Rictor in CD11c+ myeloid cells (referred to here as CD11cRicΔ/Δ), this study investigated the role of mTOR complex 2 (mTORC2) signalling in dendritic cells (DCs) function in mice. We showed that upon DSS-induced colitis, lack of mTORC2 signalling CD11c+ cells diminishes colitis score, and abrogates dendritic cell (DC) migration to the mesenteric lymph nodes ...
Source: Journal of Leukocyte Biology - April 23, 2024 Category: Hematology Authors: Aline Ignacio Marcella Cipelli Tatiane Takiishi Cristhiane Favero Aguiar Fernanda Fernandes Terra Bruno Ghirotto Eloisa Martins Silva Angela Castoldi Yuli Thamires Magalh ães Tiago Antonio Barbara Nunes Padovani Meire Ioshie Hiyane Vinicius Andrade-Olive Source Type: research
Comprehensive Analysis of Immune Signatures in Primary Biliary Cholangitis and Autoimmune Hepatitis
In conclusion, our analyses reveal that PBC and AIH share similarities and differences regarding to immune profiles. And γδ T, TIGIT+Vδ2 T, and Tfh1 cell frequencies are potential noninvasive immunological markers that can differentiate PBC from AIH.PMID:38652703 | DOI:10.1093/jleuko/qiae085 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - April 23, 2024 Category: Hematology Authors: Xiaoxue Yang Jiawei Li Meiling Ren Xuemei Pan Huiling Liu Jie Jiang Man Li Zhe Yang Bingyu Han Lina Ma Jianlei Hao Yuanyuan Duan Zhinan Yin Yan Xu Zheng Xiang Bin Wu Source Type: research
Lack of mTORC2 signalling in CD11c+ myeloid cells inhibits their migration and ameliorates experimental colitis
J Leukoc Biol. 2024 Apr 23:qiae084. doi: 10.1093/jleuko/qiae084. Online ahead of print.ABSTRACTThe Mammalian Target of Rapamycin (mTOR) pathway plays a key role in determining immune cells function through modulation of their metabolic status. By specific deletion of Rictor in CD11c+ myeloid cells (referred to here as CD11cRicΔ/Δ), this study investigated the role of mTOR complex 2 (mTORC2) signalling in dendritic cells (DCs) function in mice. We showed that upon DSS-induced colitis, lack of mTORC2 signalling CD11c+ cells diminishes colitis score, and abrogates dendritic cell (DC) migration to the mesenteric lymph nodes ...
Source: Journal of Leukocyte Biology - April 23, 2024 Category: Hematology Authors: Aline Ignacio Marcella Cipelli Tatiane Takiishi Cristhiane Favero Aguiar Fernanda Fernandes Terra Bruno Ghirotto Eloisa Martins Silva Angela Castoldi Yuli Thamires Magalh ães Tiago Antonio Barbara Nunes Padovani Meire Ioshie Hiyane Vinicius Andrade-Olive Source Type: research
Comprehensive Analysis of Immune Signatures in Primary Biliary Cholangitis and Autoimmune Hepatitis
In conclusion, our analyses reveal that PBC and AIH share similarities and differences regarding to immune profiles. And γδ T, TIGIT+Vδ2 T, and Tfh1 cell frequencies are potential noninvasive immunological markers that can differentiate PBC from AIH.PMID:38652703 | DOI:10.1093/jleuko/qiae085 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - April 23, 2024 Category: Hematology Authors: Xiaoxue Yang Jiawei Li Meiling Ren Xuemei Pan Huiling Liu Jie Jiang Man Li Zhe Yang Bingyu Han Lina Ma Jianlei Hao Yuanyuan Duan Zhinan Yin Yan Xu Zheng Xiang Bin Wu Source Type: research
Leukocyte Activation Patterns in Hospitalized Children: Comparing SARS-CoV-2, Bacterial Infections, and Inflammatory Pathologies
J Leukoc Biol. 2024 Apr 22:qiae093. doi: 10.1093/jleuko/qiae093. Online ahead of print.ABSTRACTIn adults, monocytes and neutrophils play important roles in the hyper-inflammatory responses' characteristic of severe forms of SARS-CoV-2 infection. We assessed leukocyte activation in 55 children attending the emergency department for acute fever between March 2020 and September 2021. The following markers were analyzed by flow cytometry: CD169 and HLA-DR on monocytes, CD64 and CD16 on neutrophils, CD38 on lymphocytes TCD8. Fifteen of the children had SARS-CoV-2 infection, 15 had bacterial infections, 15 had inflammatory disea...
Source: Journal of Leukocyte Biology - April 22, 2024 Category: Hematology Authors: L éa Domitien Payet Anne Sophie Bedin Émilie Desselas Carole Marie-Jeanne Caroline Mollevi Fabrice Malergue Penelope Bourgoin Philippe Van de Perre Édouard Tuaillon Éric Jeziorski Source Type: research
Calcineurin-NFAT signaling controls neutrophils ´ ability of chemoattraction upon fungal infection
J Leukoc Biol. 2024 Apr 22:qiae091. doi: 10.1093/jleuko/qiae091. Online ahead of print.ABSTRACTCalcineurin - nuclear factor of activated T-cell (CN-NFAT) inhibitors are widely clinically used drugs for immunosuppression but besides their required T-cell response inhibition, they also undesirably affect innate immune cells. Disruption of innate immune cell function can explain the observed susceptibility of CN-NFAT inhibitors-treated patients to opportunistic fungal infections. Neutrophils play an essential role in innate immunity as a defense against pathogens, however, the effect of CN-NFAT inhibitors on neutrophil functi...
Source: Journal of Leukocyte Biology - April 22, 2024 Category: Hematology Authors: O Vymazal I Papatheodorou I Andrej činová V Bos áková G Vascelli K Bend íčková T Zelante M Hortov á-Kohoutková J Fri č Source Type: research
Landscape and prognostic values of lymphocytes in patients with hepatocellular carcinoma undergoing transarterial embolization
In conclusion, TACE has a dynamic influence on the status of lymphocytes. Accordingly, several lymphocyte subsets can be used as prognostic markers for TACE.PMID:38648512 | DOI:10.1093/jleuko/qiae094 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - April 22, 2024 Category: Hematology Authors: Rui-Dong Zhao Ding-Jie Liu Jia-Wei Li Yong Wang Jun-Hao Lin Yi-Tian Zhang Yong Li Mei-Xiao Zhan Zhi-Nan Yin Li-Gong Lu Bing Liu Source Type: research
Sorting Nexin 27-dependent regulation of Lck and CD4 tunes the initial stages of T-cell activation
J Leukoc Biol. 2024 Apr 22:qiae086. doi: 10.1093/jleuko/qiae086. Online ahead of print.ABSTRACTSorting nexin (SNX) 27 is a unique member of the SNX family of proteins that mediates the endosome-to-plasma membrane trafficking of cargos bearing a PSD95/Dlg1/ZO-1 (PDZ)-binding motif. In brain, SNX27 regulates synaptic plasticity, and its dysregulation contributes to cognitive impairment and neuronal degeneration. In T lymphocytes, SNX27 partners with diacylglycerol (DAG) kinase ζ (DGKζ) to facilitate polarized traffic and signaling at the immune synapse (IS). By silencing SNX27 expression in a human T cell line, we demonstr...
Source: Journal of Leukocyte Biology - April 22, 2024 Category: Hematology Authors: Cristina Rodriguez-Rodriguez Natalia Gonz ález-Mancha Ane Ochoa-Echeverr ía Isabel M érida Source Type: research
From Tofu to T-Bones: How Vegan and Ketogenic Diets Shape Our Immune Defenses
J Leukoc Biol. 2024 Apr 22:qiae097. doi: 10.1093/jleuko/qiae097. Online ahead of print.ABSTRACTLink et al. conducted a controlled study comparing the impacts of ketogenic and vegan diets on energy intake and immune function in humans. Deep -omics analyses revealed distinct effects of each diet on the immune system, including changes in cell populations and blood transcriptomes indicative of diet-induced shifts between adaptive and innate immunity. The study highlights the potentially significant, rapid impact of diet on immune function and health.PMID:38648518 | DOI:10.1093/jleuko/qiae097 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - April 22, 2024 Category: Hematology Authors: Michael J Morowitz Source Type: research
Optimizing a five-factor cocktail to prepare reparative macrophages for wound healing
J Leukoc Biol. 2024 Apr 17:qiae096. doi: 10.1093/jleuko/qiae096. Online ahead of print.ABSTRACTThe treatment of non-healing wounds, such as diabetic ulcers, remains a critical clinical challenge. Recent breakthroughs in cell therapy have shown great promise, with one primary focus on preparing cells with comprehensive reparative functions and foreseeable safety. In our previous study, we recapitulated the pro-regenerative and immunosuppressive functions of tumor-associated macrophages (TAMs) in non-tumor-derived macrophages, endowing the latter with characteristics for promoting diabetic wound healing - termed TAMs-educate...
Source: Journal of Leukocyte Biology - April 17, 2024 Category: Hematology Authors: Rong Yong Ruoyu Mu Congwei Han Tzuwei Chao Yu Liu Lei Dong Chunming Wang Source Type: research
Induced Regulatory T Cells as Immunotherapy in Allotransplantation and Autoimmunity: Challenges and Opportunities
J Leukoc Biol. 2024 Apr 17:qiae062. doi: 10.1093/jleuko/qiae062. Online ahead of print.ABSTRACTRegulatory T cells (Tregs) play a crucial role in the homeostasis of the immune response. Tregs are mainly generated in the thymus and are characterized by the expression of Foxp3, which is considered the Treg master transcription factor. In addition, Tregs can be induced from naïve CD4+ T cells to express Foxp3 under specific conditions both in vivo (pTregs) and in vitro (iTregs). Both subsets tTregs and pTregs are necessary for the establishment of immune tolerance to self and non-self antigens. Although it has been postulated...
Source: Journal of Leukocyte Biology - April 17, 2024 Category: Hematology Authors: Evelyn Katy Alvarez-Salazar Arimelek Cort és-Hernández Sa úl Arteaga-Cruz Gloria Soldevila Source Type: research
Optimizing a five-factor cocktail to prepare reparative macrophages for wound healing
J Leukoc Biol. 2024 Apr 17:qiae096. doi: 10.1093/jleuko/qiae096. Online ahead of print.ABSTRACTThe treatment of non-healing wounds, such as diabetic ulcers, remains a critical clinical challenge. Recent breakthroughs in cell therapy have shown great promise, with one primary focus on preparing cells with comprehensive reparative functions and foreseeable safety. In our previous study, we recapitulated the pro-regenerative and immunosuppressive functions of tumor-associated macrophages (TAMs) in non-tumor-derived macrophages, endowing the latter with characteristics for promoting diabetic wound healing - termed TAMs-educate...
Source: Journal of Leukocyte Biology - April 17, 2024 Category: Hematology Authors: Rong Yong Ruoyu Mu Congwei Han Tzuwei Chao Yu Liu Lei Dong Chunming Wang Source Type: research
Induced Regulatory T Cells as Immunotherapy in Allotransplantation and Autoimmunity: Challenges and Opportunities
J Leukoc Biol. 2024 Apr 17:qiae062. doi: 10.1093/jleuko/qiae062. Online ahead of print.ABSTRACTRegulatory T cells (Tregs) play a crucial role in the homeostasis of the immune response. Tregs are mainly generated in the thymus and are characterized by the expression of Foxp3, which is considered the Treg master transcription factor. In addition, Tregs can be induced from naïve CD4+ T cells to express Foxp3 under specific conditions both in vivo (pTregs) and in vitro (iTregs). Both subsets tTregs and pTregs are necessary for the establishment of immune tolerance to self and non-self antigens. Although it has been postulated...
Source: Journal of Leukocyte Biology - April 17, 2024 Category: Hematology Authors: Evelyn Katy Alvarez-Salazar Arimelek Cort és-Hernández Sa úl Arteaga-Cruz Gloria Soldevila Source Type: research
