Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Is Biological Aging a Treatable Disease? A Consideration Based on Proposed Mechanisms of Aging
Yakugaku Zasshi. 2024;144(4):419-429. doi: 10.1248/yakushi.23-00165-5.ABSTRACTIn view of the current claim by many researchers that biological aging is a treatable disease, the possibility is discussed whether the claim is realistic, based on several proposed mechanisms of aging. The definition of biological aging is stated referring to physiological aging and pathological aging, since biological aging must be defined for the discussion of whether it can be cured. Aging in animal model is compared with that in humans in terms of common age-associated phenotypes. Major proposed mechanisms of aging are next examined includin...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Sataro Goto Source Type: research

Evaluation of the Simple Suspension Method for Oral Anticancer Drugs
Yakugaku Zasshi. 2024;144(4):441-445. doi: 10.1248/yakushi.23-00194.ABSTRACTThe simple suspension method (SSM) involves administering tablets or capsules using a tube after disintegration and suspension in hot water without crushing or opening the capsule. Particularly, for anticancer drugs, it is an excellent method of administration that reduces the risk of exposure during dispensing. In contrast, information on SSM for individual drugs is insufficient. Anticancer drugs present a therapeutic challenge because their information is limited. We investigated whether SSM is possible with 36 anticancer drugs. Furthermore, we e...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Tomoya Abe Sanae Kusakabe Miho Naoi Takayuki Suzuki Atsunobu Sagara Makoto Hiraide Motohiko Sano Toshiaki Nakayama Source Type: research

Examination of Analytical Method for Tris(2,3-dibromopropyl)phosphate and Bis(2,3-dibromopropyl)phosphate to Revise the Official Methods Based on "Act on the Control of Household Products Containing Harmful Substances"
In this study, the validity of the developed test method is evaluated at six laboratories using two types of textile samples spiked with TDBPP and BDBPP at three concentrations (4, 8, and 20 µg/g). TDBPP and BDBPP are extracted under reflux using methanol containing hydrochloric acid. TDBPP is analyzed using GC-MS, and BDBPP is also analyzed using GC-MS after methylation with trimethylsilyl diazomethane. Although the accuracy (70-120%), repeatability (<10%), and reproducibility (<15%) of a few samples, mainly low concentration samples, are out of range, overall, the concentration level of detection limits of TDBPP a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Tsuyoshi Kawakami Tomoko Ooshima Masayuki Ohyama Naeko Sugaya Iwaki Nishi Taichi Yoshitomi Hisayoshi Takai Takanari Wakayama Hiroyuki Ohno Maiko Tahara Yoshiaki Ikarashi Source Type: research

Mechanistic Analysis of Oxidative Stress-related Diseases Using Nitroxyl Radicals and Electron Spin Resonance
Yakugaku Zasshi. 2024;144(4):339-344. doi: 10.1248/yakushi.23-00141.ABSTRACTExcessive production of reactive oxygen species (ROS) causes oxidative stress and is involved in the development and progression of a wide variety of diseases. Therefore, techniques for measuring oxidative stress are indispensable for analysis of the mechanisms of various diseases. The method involving ESR and the durable nitroxyl radical (ESR/spin probe method) is useful for this purpose, because the ESR signal intensity of the spin probe changes on reacting with ROS and other unstable radicals. In this review, the author's research applying the E...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Shoko Okazaki Source Type: research

Implementation and Future of Quantitative NMR in the Pharmaceutical and Food Fields
Yakugaku Zasshi. 2024;144(4):345-346. doi: 10.1248/yakushi.23-00151-F.NO ABSTRACTPMID:38556305 | DOI:10.1248/yakushi.23-00151-F (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Nahoko Uchiyama Naoki Sugimoto Source Type: research