Patterns of red blood cell utilization: Harnessing electronic health records data from the Information Standard for Blood and Transplant (ISBT) 128 system within the Biologics Effectiveness and Safety (BEST) initiative
This study shows that the ISBT 128 coding system in an EHR environment provides a feasible source for hemovigilance activities.PMID:38689458 | DOI:10.1111/trf.17852 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Joyce Obidi Gayathri Sridhar Gra ça M Dores Barbee Whitaker Carlos H Villa Emily Storch Kinnera Chada Lisa M Schilling Karthik Natarajan Paul Biondich Andrey Soares Matthew Spotnitz Thomas Falconer Saptarshi Purkayastha Nicole L Draper Hui-Lee Wong Matth Source Type: research
Prevention of post-operative adhesions: Model development and pilot outcomes of human placental stem cell-based interventions
This study presents a novel rat model for abdominal adhesions and reports pilot results of human placental stem cell (hPSC)-based therapies.METHODS: Forty-four (n = 44) male Sprague-Dawley rats (250-350 g) were used in the experiment. Of these, thirty-eight (n = 38) were included in a preliminary data set to determine a minimum treatment effect. Adhesions were created in a reproducible model to the abdominal wall and between organs. Experimental groups included the control group (Model No Treatment, MNT), Plasmalyte A (Media Alone, MA, 10 mL), hPSC (5 × 106 cells/10 mL Plasmalyte A), hPSC-CM (hPSC secretome, conditioned m...
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Samuel P Carmichael Prafulla K Chandra John W Vaughan David M Kline Edward H Ip John B Holcomb Anthony Atala Source Type: research
Survival of transfused red blood cells from a donor with alpha-thalassemia trait in a recipient with sickle cell disease
We present one recipient, a pediatric patient with SCD and splenectomy who received two RBC units with aliquots from each unit labeled at distinct biotin densities (2 and 18 μg/mL biotin). One donor unit was identified to have microcytosis (MCV 68.5 fL after biotinylation); whole blood sample obtained at a subsequent donation showed 2-gene deletion alpha-thalassemia trait (ɑ-3.7kb/ɑ-3.7kb) and normal serum ferritin. G6PD activity was >60% of normal mean for both. The RBCs with alpha-thalassemia RBC had accelerated clearance and increased surface phosphatidylserine post-transfusion, as compared with the normocytic RBC...
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Marianne E M Yee Mischa L Covington Patricia E Zerra James W McCoy Kirk A Easley Clinton H Joiner Janetta Bryksin Richard O Francis Christopher M Lough Niren Patel Abdullah Kutlar Cassandra D Josephson John D Roback Sean R Stowell Ross M Fasano Source Type: research
High CD34-positive cell dose in matched unrelated donor allogeneic hematopoietic stem cell transplant is not associated with graft-versus-host disease or mortality
DISCUSSION: We found no difference in survival, relapse, or GVHD incidence or severity in patients receiving CD34+ doses above prior cutoffs reported in the literature. These data do not support the routine use of graft CD34+ dose reduction.PMID:38693089 | DOI:10.1111/trf.17864 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Zachary M Avigan Ajoy L Dias Laura E Dodge Jon E Arnason Robin M Joyce Jessica Liegel Jacalyn Rosenblatt Matthew J Weinstock David E Avigan Richard L Haspel Source Type: research
Measuring the effectiveness of online search ads on blood donor recruitment and donation
CONCLUSION: We developed a method for determining the effectiveness of online search ads on donation outcomes. Rewards/promotions messaging was most effective at recruiting first-time donors. Our methodology is generalizable to different blood centers to explore messaging effectiveness among their unique communities.PMID:38693096 | DOI:10.1111/trf.17850 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Duncan C McElfresh Jennifer Bennet Kay Enriquez Tho D Pham Source Type: research
Severe neonatal thrombocytopenia due to anti-HPA-4b alloantibodies: Third report described in a Caucasian mother
CONCLUSION: We described the third case of anti-HPA-4b alloantibody discovered in a Caucasian mother. This case strengthens the need for reference laboratory to genotype a panel of HPA alleles reflecting local genetic population diversity and for crossmatch of maternal serum with fresh paternal platelets in clinical suspected cases of neonatal alloimmune thrombocytopenia.PMID:38693097 | DOI:10.1111/trf.17863 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Rachel Petermann Fr édéric Bianchi Loubna Saib Nicolas Ferr é Nathalie Francelle Olivier Oudin Christophe Chenet Yasmine Mammasse Vincent Jallu Am élie Chaussade Antonin Cornu Laureline Dubray Agn ès Mailloux Source Type: research
Why are we donating less?
Transfusion. 2024 May 1. doi: 10.1111/trf.17861. Online ahead of print.NO ABSTRACTPMID:38693100 | DOI:10.1111/trf.17861 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Minh-Ha Tran ChenChen Niu Walter Kelley Source Type: research
In memoriam: Dr. Dirk de Korte: June 10, 1955 to March 22, 2024
Transfusion. 2024 May 1. doi: 10.1111/trf.17834. Online ahead of print.NO ABSTRACTPMID:38693467 | DOI:10.1111/trf.17834 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Raymond P Goodrich Source Type: research
Patterns of red blood cell utilization: Harnessing electronic health records data from the Information Standard for Blood and Transplant (ISBT) 128 system within the Biologics Effectiveness and Safety (BEST) initiative
This study shows that the ISBT 128 coding system in an EHR environment provides a feasible source for hemovigilance activities.PMID:38689458 | DOI:10.1111/trf.17852 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Joyce Obidi Gayathri Sridhar Gra ça M Dores Barbee Whitaker Carlos H Villa Emily Storch Kinnera Chada Lisa M Schilling Karthik Natarajan Paul Biondich Andrey Soares Matthew Spotnitz Thomas Falconer Saptarshi Purkayastha Nicole L Draper Hui-Lee Wong Matth Source Type: research
Prevention of post-operative adhesions: Model development and pilot outcomes of human placental stem cell-based interventions
This study presents a novel rat model for abdominal adhesions and reports pilot results of human placental stem cell (hPSC)-based therapies.METHODS: Forty-four (n = 44) male Sprague-Dawley rats (250-350 g) were used in the experiment. Of these, thirty-eight (n = 38) were included in a preliminary data set to determine a minimum treatment effect. Adhesions were created in a reproducible model to the abdominal wall and between organs. Experimental groups included the control group (Model No Treatment, MNT), Plasmalyte A (Media Alone, MA, 10 mL), hPSC (5 × 106 cells/10 mL Plasmalyte A), hPSC-CM (hPSC secretome, conditioned m...
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Samuel P Carmichael Prafulla K Chandra John W Vaughan David M Kline Edward H Ip John B Holcomb Anthony Atala Source Type: research
Survival of transfused red blood cells from a donor with alpha-thalassemia trait in a recipient with sickle cell disease
We present one recipient, a pediatric patient with SCD and splenectomy who received two RBC units with aliquots from each unit labeled at distinct biotin densities (2 and 18 μg/mL biotin). One donor unit was identified to have microcytosis (MCV 68.5 fL after biotinylation); whole blood sample obtained at a subsequent donation showed 2-gene deletion alpha-thalassemia trait (ɑ-3.7kb/ɑ-3.7kb) and normal serum ferritin. G6PD activity was >60% of normal mean for both. The RBCs with alpha-thalassemia RBC had accelerated clearance and increased surface phosphatidylserine post-transfusion, as compared with the normocytic RBC...
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Marianne E M Yee Mischa L Covington Patricia E Zerra James W McCoy Kirk A Easley Clinton H Joiner Janetta Bryksin Richard O Francis Christopher M Lough Niren Patel Abdullah Kutlar Cassandra D Josephson John D Roback Sean R Stowell Ross M Fasano Source Type: research
High CD34-positive cell dose in matched unrelated donor allogeneic hematopoietic stem cell transplant is not associated with graft-versus-host disease or mortality
DISCUSSION: We found no difference in survival, relapse, or GVHD incidence or severity in patients receiving CD34+ doses above prior cutoffs reported in the literature. These data do not support the routine use of graft CD34+ dose reduction.PMID:38693089 | DOI:10.1111/trf.17864 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Zachary M Avigan Ajoy L Dias Laura E Dodge Jon E Arnason Robin M Joyce Jessica Liegel Jacalyn Rosenblatt Matthew J Weinstock David E Avigan Richard L Haspel Source Type: research
Measuring the effectiveness of online search ads on blood donor recruitment and donation
CONCLUSION: We developed a method for determining the effectiveness of online search ads on donation outcomes. Rewards/promotions messaging was most effective at recruiting first-time donors. Our methodology is generalizable to different blood centers to explore messaging effectiveness among their unique communities.PMID:38693096 | DOI:10.1111/trf.17850 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Duncan C McElfresh Jennifer Bennet Kay Enriquez Tho D Pham Source Type: research
Severe neonatal thrombocytopenia due to anti-HPA-4b alloantibodies: Third report described in a Caucasian mother
CONCLUSION: We described the third case of anti-HPA-4b alloantibody discovered in a Caucasian mother. This case strengthens the need for reference laboratory to genotype a panel of HPA alleles reflecting local genetic population diversity and for crossmatch of maternal serum with fresh paternal platelets in clinical suspected cases of neonatal alloimmune thrombocytopenia.PMID:38693097 | DOI:10.1111/trf.17863 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Rachel Petermann Fr édéric Bianchi Loubna Saib Nicolas Ferr é Nathalie Francelle Olivier Oudin Christophe Chenet Yasmine Mammasse Vincent Jallu Am élie Chaussade Antonin Cornu Laureline Dubray Agn ès Mailloux Source Type: research
Why are we donating less?
Transfusion. 2024 May 1. doi: 10.1111/trf.17861. Online ahead of print.NO ABSTRACTPMID:38693100 | DOI:10.1111/trf.17861 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Minh-Ha Tran ChenChen Niu Walter Kelley Source Type: research
