Radiofrequency identification tracking system (RFID) significantly improves blood bank inventory management and decreases staff work effort
DISCUSSION: Implementation of RFID technology substantially reduced RBC product loss, improved inventory management, and lessened staff work burden.PMID:38419577 | DOI:10.1111/trf.17771 (Source: Transfusion)
Source: Transfusion - February 29, 2024 Category: Hematology Authors: Antoine Tavares da Souza Jennylyn Flores Loevette Millendez Marites Filio Yunchuan Delores Mo Cyril Jacquot Meghan Delaney Source Type: research
Significant changes to AABB Standards: Updated quality system essentials
Transfusion. 2024 Feb 29. doi: 10.1111/trf.17773. Online ahead of print.ABSTRACTIn the late 1990s, AABB joined many other accrediting organizations in embracing a quality system approach to setting standards. This change, seen at the time as the new era of standards-setting, was marked by a shift from error detection to error prevention as the main emphasis. AABB termed the framework for this approach "quality system essentials (QSEs)." These QSEs were incorporated into all eight AABB Standards. The QSEs enhanced the existing technical requirements and have been updated regularly since then for all operational areas in whi...
Source: Transfusion - February 29, 2024 Category: Hematology Authors: Patrick Ooley Christopher Bocquet Source Type: research
Estimated median density identifies donor age and sex differences in red blood cell biological age
CONCLUSIONS: This study provides further evidence that there are inherent differences between the biological age profiles of RBCs between blood donors of different sex and age. Our findings further highlight that biological age may contribute to RBC quality during storage and that donor characteristics need to be considered when evaluating transfusion safety and efficacy.PMID:38420746 | DOI:10.1111/trf.17749 (Source: Transfusion)
Source: Transfusion - February 29, 2024 Category: Hematology Authors: Olga Mykhailova Mackenzie Brandon-Coatham Kiarra Durand Carly Olafson April Xu Qi-Long Yi Tamir Kanias Jason P Acker Source Type: research
Maternal and child life years gained by transfusing low titer group O whole blood in trauma: A computer simulation
CONCLUSION: In this model, RhD-positive LTOWB resulted in substantial gains in maternal and child life years compared with CCT. A >0.1% relative mortality reduction from LTOWB offset the life years lost to HDFN mortality and severe neurological events.PMID:38404198 | DOI:10.1111/trf.17767 (Source: Transfusion)
Source: Transfusion - February 26, 2024 Category: Hematology Authors: Mark H Yazer Christine Leeper Philip C Spinella Stephen P Emery Sarah Horvath Jansen N Seheult Source Type: research
Impact of plerixafor use in the mobilization of blood grafts for autologous hematopoietic cell transplantation
Transfusion. 2024 Feb 26. doi: 10.1111/trf.17755. Online ahead of print.ABSTRACTPlerixafor (PLER), a reversible antagonist of the CXC chemokine receptor type 4, has been in clinical use for mobilization of blood grafts for autologous hematopoietic cell transplantation (AHCT) for about 15 years. Initially PLER was investigated in placebo-controlled trials with the granulocyte colony-stimulating factor (G-CSF) filgrastim. It has also been used in combination with chemotherapy plus G-CSF in patients who had failed a previous mobilization attempt or appeared to mobilize poorly with current mobilization (preemptive use). This r...
Source: Transfusion - February 26, 2024 Category: Hematology Authors: Esa Jantunen Antti Turunen Ville Varmavuo Anu Partanen Source Type: research
Maternal and child life years gained by transfusing low titer group O whole blood in trauma: A computer simulation
CONCLUSION: In this model, RhD-positive LTOWB resulted in substantial gains in maternal and child life years compared with CCT. A >0.1% relative mortality reduction from LTOWB offset the life years lost to HDFN mortality and severe neurological events.PMID:38404198 | DOI:10.1111/trf.17767 (Source: Transfusion)
Source: Transfusion - February 26, 2024 Category: Hematology Authors: Mark H Yazer Christine Leeper Philip C Spinella Stephen P Emery Sarah Horvath Jansen N Seheult Source Type: research
Impact of plerixafor use in the mobilization of blood grafts for autologous hematopoietic cell transplantation
Transfusion. 2024 Feb 26. doi: 10.1111/trf.17755. Online ahead of print.ABSTRACTPlerixafor (PLER), a reversible antagonist of the CXC chemokine receptor type 4, has been in clinical use for mobilization of blood grafts for autologous hematopoietic cell transplantation (AHCT) for about 15 years. Initially PLER was investigated in placebo-controlled trials with the granulocyte colony-stimulating factor (G-CSF) filgrastim. It has also been used in combination with chemotherapy plus G-CSF in patients who had failed a previous mobilization attempt or appeared to mobilize poorly with current mobilization (preemptive use). This r...
Source: Transfusion - February 26, 2024 Category: Hematology Authors: Esa Jantunen Antti Turunen Ville Varmavuo Anu Partanen Source Type: research
Maternal and child life years gained by transfusing low titer group O whole blood in trauma: A computer simulation
CONCLUSION: In this model, RhD-positive LTOWB resulted in substantial gains in maternal and child life years compared with CCT. A >0.1% relative mortality reduction from LTOWB offset the life years lost to HDFN mortality and severe neurological events.PMID:38404198 | DOI:10.1111/trf.17767 (Source: Transfusion)
Source: Transfusion - February 26, 2024 Category: Hematology Authors: Mark H Yazer Christine Leeper Philip C Spinella Stephen P Emery Sarah Horvath Jansen N Seheult Source Type: research
Impact of plerixafor use in the mobilization of blood grafts for autologous hematopoietic cell transplantation
Transfusion. 2024 Feb 26. doi: 10.1111/trf.17755. Online ahead of print.ABSTRACTPlerixafor (PLER), a reversible antagonist of the CXC chemokine receptor type 4, has been in clinical use for mobilization of blood grafts for autologous hematopoietic cell transplantation (AHCT) for about 15 years. Initially PLER was investigated in placebo-controlled trials with the granulocyte colony-stimulating factor (G-CSF) filgrastim. It has also been used in combination with chemotherapy plus G-CSF in patients who had failed a previous mobilization attempt or appeared to mobilize poorly with current mobilization (preemptive use). This r...
Source: Transfusion - February 26, 2024 Category: Hematology Authors: Esa Jantunen Antti Turunen Ville Varmavuo Anu Partanen Source Type: research
Functional effects of an African glucose-6-phosphate dehydrogenase (G6PD) polymorphism (Val68Met) on red blood cell hemolytic propensity and post-transfusion recovery
DISCUSSION: This novel mouse model of the common G6PD A- variant has impaired antioxidant capacity like humans and low G6PD activity may reduce survival of transfused RBCs when irradiation is performed.PMID:38400625 | DOI:10.1111/trf.17756 (Source: Transfusion)
Source: Transfusion - February 24, 2024 Category: Hematology Authors: Ling Wang Elizabeth R Rochon Sebastien Gingras Benjamin E Zuchelkowski Derek J Sinchar Elimira Alipour Julie A Reisz Minying Yang Grier P Page Tamir Kanias Darrell J Triulzi Janet S Lee Daniel B Kim-Shapiro Angelo D'Alessandro Mark T Gladwin Source Type: research
Autoantibody profiles in intravenous immunoglobulin preparations: A possible cause of mistaken autoimmunity diagnosis
DISCUSSION: To the best of our knowledge, this is the first study that analyzed multiple autoantibody profiles in both pooled plasma and IVIg products and that further evaluated their potential influences on diagnosis of autoimmunity. Clinicians should keep in mind that IVIgs contain several autoantibodies and that their infusion can produce false-positive serology results. To establish an accurate diagnosis, serological tests must be carefully interpreted and clinical symptoms should be more purposefully considered if patients are receiving IVIg therapy.PMID:38400628 | DOI:10.1111/trf.17766 (Source: Transfusion)
Source: Transfusion - February 24, 2024 Category: Hematology Authors: Tatsuki Miyamoto Yuki Fukunaga Atsushi Ogasawara Ai Munakata Katsushi Murai Source Type: research
The T ägerwilen II report: Recommendations from the NATO Prehospital Care Improvement Initiative Task Force
CONCLUSION: The recommendations on these four themes reflect the most significant priorities in improving prehospital care, and must be incorporated in the on-going revision of NATO doctrine.PMID:38400632 | DOI:10.1111/trf.17760 (Source: Transfusion)
Source: Transfusion - February 24, 2024 Category: Hematology Authors: Christian Medby Colleen Forestier Benjamin Ingram Duncan Parkhouse Michael Alvarez-Brueckmann Alexander Faas Source Type: research
Generation of human antibodies targeting human platelet antigen (HPA)-1a
This study aimed to isolate HPA-1a-specific B-cells from an HPA-1a-alloimmunized pregnant woman. Using fluorescently labeled HPA-1a-positive platelets, single B-cells were sorted and cultured for 10 days to stimulate antibody production. Subsequently, supernatants were tested for the presence of antibodies by enzyme-linked immunosorbent assay and their reactivity towards HPA-1a-positive platelets. Amplification and sequencing of variable regions allowed the generation of monoclonal antibodies using a HEK-Freestyle-based expression system.RESULTS: Three platelet-specific B-cells were obtained and cloned of which two were sp...
Source: Transfusion - February 24, 2024 Category: Hematology Authors: Janita J Oosterhoff Federica Linty Remco Visser Thijs de Vos Suzanne Hofstede-van Egmond Miranda van de Weerd Leendert Porcelijn Masja de Haas Ellen van der Schoot Gestur Vidarsson Source Type: research
Blood donation and migraine relief: A national population cohort study in Denmark
DISCUSSION: Our findings do not support the hypothesis that blood donation serves as a viable treatment strategy among migraine patients. Future prospective investigations may help to elucidate the underlying biological mechanisms by which blood donation may influence migraine pathology.PMID:38400775 | DOI:10.1111/trf.17770 (Source: Transfusion)
Source: Transfusion - February 24, 2024 Category: Hematology Authors: Olafur B Davidsson Klaus Rostgaard Mona A Chalmer Lisette J A Kogelman Bitten Aagaard Thorsten Brodersen Mie Topholm Bruun Christina Mikkelsen Susan Mikkelsen Mette Nyegaard Ole Birger Pedersen Henrik Ullum Erik S ørensen Sisse Rye Ostrowski Christian Er Source Type: research
Classification of posttransfusion adverse events using a publicly available artificial intelligence system
DISCUSSION: A generative AI system may have a role in helping healthcare providers to consider transfusion reaction categories that might be missed, but caution is advised in applying the AI's output to transfusion reaction classification at present.PMID:38400777 | DOI:10.1111/trf.17702 (Source: Transfusion)
Source: Transfusion - February 24, 2024 Category: Hematology Authors: Mark K Fung James P AuBuchon Laura D Stephens Source Type: research
