Survival of transfused red blood cells from a donor with alpha-thalassemia trait in a recipient with sickle cell disease

We present one recipient, a pediatric patient with SCD and splenectomy who received two RBC units with aliquots from each unit labeled at distinct biotin densities (2 and 18 μg/mL biotin). One donor unit was identified to have microcytosis (MCV 68.5 fL after biotinylation); whole blood sample obtained at a subsequent donation showed 2-gene deletion alpha-thalassemia trait (ɑ-3.7kb/ɑ-3.7kb) and normal serum ferritin. G6PD activity was >60% of normal mean for both. The RBCs with alpha-thalassemia RBC had accelerated clearance and increased surface phosphatidylserine post-transfusion, as compared with the normocytic RBC (half life 65 vs. 86 days, respectively).DISCUSSION: Post-transfusion RBC survival may be lower for units from donors with alpha-thalassemia trait, although the impact of thalassemia trait donors on transfusion efficacy requires further study.PMID:38693059 | DOI:10.1111/trf.17857

Source: Transfusion - May 1, 2024 Category: Hematology Authors: Marianne E M Yee Mischa L Covington Patricia E Zerra James W McCoy Kirk A Easley Clinton H Joiner Janetta Bryksin Richard O Francis Christopher M Lough Niren Patel Abdullah Kutlar Cassandra D Josephson John D Roback Sean R Stowell Ross M Fasano Source Type: research