A global analysis of the use of immunoglobulin, shortages in supply, and mitigating measures: A survey of hospital providers (a BEST Collaborative study)
DISCUSSION: As IG is the leading driver in plasma demand, more studies are needed to understand current and future demand for IG from the clinical perspective. Necessity lies in establishing clinical guidance to address shortages.PMID:38516758 | DOI:10.1111/trf.17801 (Source: Transfusion)
Source: Transfusion - March 22, 2024 Category: Hematology Authors: Cynthia So-Osman Meghan Delaney Mark Fung Wen Lu Michael Murphy Praiseldy Langi Sasongko Pierre Tiberghien Alan Tinmouth Best ImmunoGlobulin (BIG) Study Group* the Biomedical Excellence for Safer Transfusion Collaborative Source Type: research
Patient sex and outcomes in children with life-threatening hemorrhage
CONCLUSION: Patient sex and age may impact factors associated with LTH and therapies received. Studies in developmental hemostasis are needed to determine the optimal transfusion strategy for LTH according to patient sex and age.PMID:38511654 | DOI:10.1111/trf.17805 (Source: Transfusion)
Source: Transfusion - March 21, 2024 Category: Hematology Authors: Julia H Kolodziej Philip C Spinella Joshua B Brown Liling Lu Cassandra D Josephson Julie C Leonard Christine M Leeper Source Type: research
Increased platelet to red blood cell transfusion ratio associated with acute kidney injury in children with life-threatening bleeding
CONCLUSION: The use of increased platelet to red blood cell transfusion ratios in children with life-threatening bleeding of any etiology may increase the risk of AKI but not ARDS. Prospective trials are needed to determine if increased platelet use in this cohort increases the risk of AKI to examine possible mechanisms.PMID:38511721 | DOI:10.1111/trf.17788 (Source: Transfusion)
Source: Transfusion - March 21, 2024 Category: Hematology Authors: Rachel Vaizer Christine M Leeper Liling Lu Cassandra D Josephson Julie C Leonard Joshua B Brown Philip C Spinella Source Type: research
Evaluating the effects of hypoxic storage on platelet function and health using a novel storage system
This study indicates that platelets are sensitive to hypoxic storage and suffer significant metabolic and functional deterioration when stored at or below 10% HbSO2.PMID:38511850 | DOI:10.1111/trf.17784 (Source: Transfusion)
Source: Transfusion - March 21, 2024 Category: Hematology Authors: A J Weaver C S McIntosh S G Kelly G D Barrera S Lizarraga K E Hildreth C E Williams L Grantham T Yoshida L Omert J A Bynum M A Meledeo K M Reddoch-Cardenas Source Type: research
Factors affecting physicians' decision to start prehospital blood product transfusion in blunt trauma patients: A cohort study of Helsinki Trauma Registry
DISCUSSION: PHBT in blunt adult trauma patients is initiated in ~20% of the patients in Southern Finland. High crystalloid volume need, shock index ≥0.9 and prehospital pleural decompression are associated with the initiation of PHBT, probably reflecting patients at high risk for bleeding.PMID:38511866 | DOI:10.1111/trf.17791 (Source: Transfusion)
Source: Transfusion - March 21, 2024 Category: Hematology Authors: Timo Jama Rolf Lefering Jouni Lauronen Lauri Handolin Source Type: research
Quality of life and cost-effectiveness of convalescent plasma compared to standard care for hospitalized COVID-19 patients in the CONCOR-1 trial
This study evaluates the cost-effectiveness of convalescent plasma and its impact on quality-of-life to provide insight into its potential as an alternative treatment in resource-constrained settings.METHODS: Individual patient data on health outcomes and resource utilization from the CONCOR-1 trial were used to conduct the analysis from the Canadian public payer's perspective with a time horizon of 30 days post-randomization. Baseline and 30-day EQ-5D-5L were measured to calculate quality-adjusted survival. All costs are presented in 2021 Canadian dollars. The base case assessed the EQ-5D-5L scores of hospitalized inpatie...
Source: Transfusion - March 21, 2024 Category: Hematology Authors: Preston Tse Jiajun Yan Yang Liu Erin Jamula Nancy Heddle Ren ée Bazin Nancy Robitaille Richard Cook Alexis Turgeon Dean Fergusson Marshall Glesby Kent Cadogan Loftsgard Melissa Cushing Micha ël Chassé Nick Daneman Andr és Finzi Bruce Sachais Philippe Source Type: research
Post-transfusion biotin-labeled red blood cell survival studies in pediatric sickle cell disease with antibodies of uncertain significance
DISCUSSION: Biotinylation of allogenic RBC can be used to assess the possible effects of RBC antibodies on transfusion survival in individual cases, particularly when it is uncertain if the detected antibodies may result in hemolysis. In the cases presented here, neither WAA nor B-RBC antibodies were associated with significant shortening of B-RBC survival in individuals with SCD.PMID:38506450 | DOI:10.1111/trf.17800 (Source: Transfusion)
Source: Transfusion - March 20, 2024 Category: Hematology Authors: Marianne E M Yee Patricia E Zerra James W McCoy Mischa L Covington Sean R Stowell Clinton H Joiner Christopher M Lough Bhaveshkumar B Delvadia Cassandra D Josephson John D Roback Ross M Fasano Source Type: research
Using the daily rate of rise in hemoglobin S to manage RBC depletion/exchange treatment in sickle cell disease
DISCUSSION: The RoR in HbS is a relatively consistent parameter for individual patients that is unaffected by medication use or procedural Hct targets and may be useful in determining intervals between procedures.PMID:38506484 | DOI:10.1111/trf.17797 (Source: Transfusion)
Source: Transfusion - March 20, 2024 Category: Hematology Authors: Kai Rogers Mouaz Alsawas James Chapman Annette J Schlueter Charles Michael Knudson Source Type: research
What is the environmental impact of a blood transfusion? A life cycle assessment of transfusion services across England
DISCUSSION: This is the first study to estimate GHG emissions attributable to RBC transfusion, quantifying the contributions of each stage of the process. Primary areas for mitigation may include electric vehicles for the blood service fleet, improving the energy efficiency of refrigeration, using renewable sources of electricity, changing the plastic of blood packs, and using methods of disposal other than incineration.PMID:38506497 | DOI:10.1111/trf.17786 (Source: Transfusion)
Source: Transfusion - March 20, 2024 Category: Hematology Authors: Stephen P Hibbs Stephen Thomas Nikhil Agarwal Charlotte Andrews Sylvia Eskander Aaliyah Sharif Abdalla Julie Staves Matthew J Eckelman Michael F Murphy Source Type: research
Post-transfusion biotin-labeled red blood cell survival studies in pediatric sickle cell disease with antibodies of uncertain significance
DISCUSSION: Biotinylation of allogenic RBC can be used to assess the possible effects of RBC antibodies on transfusion survival in individual cases, particularly when it is uncertain if the detected antibodies may result in hemolysis. In the cases presented here, neither WAA nor B-RBC antibodies were associated with significant shortening of B-RBC survival in individuals with SCD.PMID:38506450 | DOI:10.1111/trf.17800 (Source: Transfusion)
Source: Transfusion - March 20, 2024 Category: Hematology Authors: Marianne E M Yee Patricia E Zerra James W McCoy Mischa L Covington Sean R Stowell Clinton H Joiner Christopher M Lough Bhaveshkumar B Delvadia Cassandra D Josephson John D Roback Ross M Fasano Source Type: research
Using the daily rate of rise in hemoglobin S to manage RBC depletion/exchange treatment in sickle cell disease
DISCUSSION: The RoR in HbS is a relatively consistent parameter for individual patients that is unaffected by medication use or procedural Hct targets and may be useful in determining intervals between procedures.PMID:38506484 | DOI:10.1111/trf.17797 (Source: Transfusion)
Source: Transfusion - March 20, 2024 Category: Hematology Authors: Kai Rogers Mouaz Alsawas James Chapman Annette J Schlueter Charles Michael Knudson Source Type: research
What is the environmental impact of a blood transfusion? A life cycle assessment of transfusion services across England
DISCUSSION: This is the first study to estimate GHG emissions attributable to RBC transfusion, quantifying the contributions of each stage of the process. Primary areas for mitigation may include electric vehicles for the blood service fleet, improving the energy efficiency of refrigeration, using renewable sources of electricity, changing the plastic of blood packs, and using methods of disposal other than incineration.PMID:38506497 | DOI:10.1111/trf.17786 (Source: Transfusion)
Source: Transfusion - March 20, 2024 Category: Hematology Authors: Stephen P Hibbs Stephen Thomas Nikhil Agarwal Charlotte Andrews Sylvia Eskander Aaliyah Sharif Abdalla Julie Staves Matthew J Eckelman Michael F Murphy Source Type: research
Survey of policies at US hospitals on the selection of RhD type of low-titer O whole blood for use in trauma resuscitation
CONCLUSION: Hospitals prefer issuing RhD-negative LTOWB for females although they are often ineligible to receive RhD-negative LTOWB due to supply constraints. The risk and benefits of LTOWB compared to the rare occurrence of hemolytic disease of the fetus/newborn (HDFN) need further examination in the context of withholding a therapy for females that has the potential for improved outcomes.PMID:38501231 | DOI:10.1111/trf.17789 (Source: Transfusion)
Source: Transfusion - March 19, 2024 Category: Hematology Authors: Skye Clayton Christine M Leeper Mark H Yazer Philip C Spinella Source Type: research
"Okay, I respect this publicity stunt." A snapshot of public perceptions of an online game-based blood donation campaign
DISCUSSION: Situating a donation campaign in an established video game provides a novel opportunity to engage young donors. Through capturing public data, we provide a unique snapshot of how an online gaming community perceives and reacts to an independently initiated game-integrated blood donation campaign. This highlights key strengths of the approach as well as identifying potential risks for blood collection agencies.PMID:38501236 | DOI:10.1111/trf.17794 (Source: Transfusion)
Source: Transfusion - March 19, 2024 Category: Hematology Authors: Abigail Edwards Barbara Masser Source Type: research
Blood transfusion: What if ….?
Transfusion. 2024 Mar 19. doi: 10.1111/trf.17744. Online ahead of print.NO ABSTRACTPMID:38501252 | DOI:10.1111/trf.17744 (Source: Transfusion)
Source: Transfusion - March 19, 2024 Category: Hematology Authors: Emily Mayhew Source Type: research
