Carboxymethyl cellulose/Sodium alginate Hydrogel with Anti-inflammatory capabilities for Accelerated Wound healing; In vitro and In vivo study
This study aims to develop a new type of immunomodulatory wound dressing utilizing carboxymethyl cellulose (CMC)/sodium alginate (Alg)-simvastatin (SIM) to simultaneously enhance the inflammatory responses and the wound healing ratio. The CMC/Alg-SIM hydrogels exhibited appropriate swelling ratio, water vapor transmission rate, and desirable degradation rate, depending on the SIM content. The fabricated dressing showed sustained release of SIM (during 5 days) that improved the proliferation of skin cells. According to the in vitro findings, the CMC/Alg-SIM hydrogel exhibited controlled pro-inflammatory responses (decreased...
Source: European Journal of Pharmacology - May 26, 2024 Category: Drugs & Pharmacology Authors: Seyed Mohammad Reza Hosseini Parisa Heydari Mahtab Namnabat Reyhaneh Nasr Azadani Fateme Azimi Gharibdousti Elmira Mousavi Rizi Arezoo Khosravi Atefeh Zarepour Ali Zarrabi Source Type: research
Gibberellic acid targeting ZBTB16 reduces NF- κB dependent inflammatory stress in sepsis-induced neuroinflammation
CONCLUSIONS: Pre-incubation of microglia with GA3 led to the upregulation of the NF-κB regulator, Zbtb16. This process counteracted LPS-induced microglial M1 activation, resulting in an anti-inflammatory effect upon subsequent LPS stimulation.PMID:38797312 | DOI:10.1016/j.ejphar.2024.176665 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - May 26, 2024 Category: Drugs & Pharmacology Authors: Hao-Jie Xu Ying-Yi Lin Jian-Jun Yu Na Zhang Jia-Min Hu Jin-Shuang Qu Chao-Mei Yuan Da-Qiu Chen Min Liang Hong-da Cai Kai Zeng Source Type: research
Effect of hyperoside on osteoporosis in ovariectomized mice through estrogen receptor α/ITG β3 signaling pathway
This study investigates the potential mechanism of hyperoside's anti-osteoporotic effect by examining its impact on osteoclast differentiation and its relationship with the estrogen receptor. DXA, Micro-CT, TRAP staining, HE, and ELISA were used to assess the impact of hyperoside on OVX-induced osteoporosis. The effect of hyperoside on octeoclast differentiation was evaluated using TRAP activity assay, TRAP staining, F-actin staining. The activation of the estrogen receptor by hyperoside and its relationship with osteoclast differentiation were detected using dual-luciferase reporter assay and estrogen receptor antagonists...
Source: European Journal of Pharmacology - May 26, 2024 Category: Drugs & Pharmacology Authors: Qiu Wei MingHui Ouyang Xiaotong Guo Xiaoyu Fu Ting Liu Yage Luo Huajing Tang Yun Yang Xiumei Gao Haoping Mao Source Type: research
Carboxymethyl cellulose/Sodium alginate Hydrogel with Anti-inflammatory capabilities for Accelerated Wound healing; In vitro and In vivo study
This study aims to develop a new type of immunomodulatory wound dressing utilizing carboxymethyl cellulose (CMC)/sodium alginate (Alg)-simvastatin (SIM) to simultaneously enhance the inflammatory responses and the wound healing ratio. The CMC/Alg-SIM hydrogels exhibited appropriate swelling ratio, water vapor transmission rate, and desirable degradation rate, depending on the SIM content. The fabricated dressing showed sustained release of SIM (during 5 days) that improved the proliferation of skin cells. According to the in vitro findings, the CMC/Alg-SIM hydrogel exhibited controlled pro-inflammatory responses (decreased...
Source: European Journal of Pharmacology - May 26, 2024 Category: Drugs & Pharmacology Authors: Seyed Mohammad Reza Hosseini Parisa Heydari Mahtab Namnabat Reyhaneh Nasr Azadani Fateme Azimi Gharibdousti Elmira Mousavi Rizi Arezoo Khosravi Atefeh Zarepour Ali Zarrabi Source Type: research
Gibberellic acid targeting ZBTB16 reduces NF- κB dependent inflammatory stress in sepsis-induced neuroinflammation
CONCLUSIONS: Pre-incubation of microglia with GA3 led to the upregulation of the NF-κB regulator, Zbtb16. This process counteracted LPS-induced microglial M1 activation, resulting in an anti-inflammatory effect upon subsequent LPS stimulation.PMID:38797312 | DOI:10.1016/j.ejphar.2024.176665 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - May 26, 2024 Category: Drugs & Pharmacology Authors: Hao-Jie Xu Ying-Yi Lin Jian-Jun Yu Na Zhang Jia-Min Hu Jin-Shuang Qu Chao-Mei Yuan Da-Qiu Chen Min Liang Hong-da Cai Kai Zeng Source Type: research
Effect of hyperoside on osteoporosis in ovariectomized mice through estrogen receptor α/ITG β3 signaling pathway
This study investigates the potential mechanism of hyperoside's anti-osteoporotic effect by examining its impact on osteoclast differentiation and its relationship with the estrogen receptor. DXA, Micro-CT, TRAP staining, HE, and ELISA were used to assess the impact of hyperoside on OVX-induced osteoporosis. The effect of hyperoside on octeoclast differentiation was evaluated using TRAP activity assay, TRAP staining, F-actin staining. The activation of the estrogen receptor by hyperoside and its relationship with osteoclast differentiation were detected using dual-luciferase reporter assay and estrogen receptor antagonists...
Source: European Journal of Pharmacology - May 26, 2024 Category: Drugs & Pharmacology Authors: Qiu Wei MingHui Ouyang Xiaotong Guo Xiaoyu Fu Ting Liu Yage Luo Huajing Tang Yun Yang Xiumei Gao Haoping Mao Source Type: research
Corrigendum to "Low-intensity pulsed ultrasound prevents angiotensin II-induced aortic smooth muscle cell phenotypic switch via hampering miR-17-5p and enhancing PPAR- γ" [Eur. J. Pharmacol. 911 (2021):174509]
Eur J Pharmacol. 2024 May 24;975:176662. doi: 10.1016/j.ejphar.2024.176662. Online ahead of print.NO ABSTRACTPMID:38795429 | DOI:10.1016/j.ejphar.2024.176662 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - May 25, 2024 Category: Drugs & Pharmacology Authors: Kun Zhao Tingting Wu Chuanxi Yang Haotian Pan Tianhua Xu Jing Zhang Xiasheng Guo Juan Tu Dong Zhang Xiangqing Kong Bin Zhou Wei Sun Source Type: research
Novel Drug Discovery: Advancing Alzheimer's Therapy through Machine Learning and Network Pharmacology
In conclusion, our study establishes a solid foundation for the use of these drugs in AD therapy. Thus current study highlights the possibility of multi-targeted, synergistic therapeutic approaches in addressing the complex pathophysiology of AD by integrating machine learning, network pharmacology, and molecular docking simulations. This holistic technique not only advances drug development but also opens up new avenues for developing more effective treatments for this difficult and widespread disease.PMID:38795753 | DOI:10.1016/j.ejphar.2024.176661 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - May 25, 2024 Category: Drugs & Pharmacology Authors: Fahad M Alshabrmi Faris F Aba Alkhayl Abdur Rehman Source Type: research
Fenofibrate ameliorates nitroglycerin-induced migraine in rats: Role of CGRP/p-CREB/P2X3 and NGF/PKC/ASIC3 signaling pathways
This study demonstrates that fenofibrate attenuated NTG-induced migraine-like signs in rats. These effects were partially mediated through the inhibition of CGRP/p-CREB/P2X3 and NGF/PKC/ASIC3 signaling pathways. The present study supports the idea that fenofibrate could be an effective candidate for treating migraine headache without significant adverse effects. Future studies should explore its clinical applicability.PMID:38795754 | DOI:10.1016/j.ejphar.2024.176667 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - May 25, 2024 Category: Drugs & Pharmacology Authors: Hassan A Ruby Rabab H Sayed Mohamed A Khattab Nada A Sallam Sanaa A Kenway Source Type: research
Improvement of Neuronal and Cognitive Functions Following Treatment with 3',4' Dihydroxyflavonol in Experimental Focal Cerebral Ischemia-Reperfusion Injury in Rats
CONCLUSIONS: The results of the study show that brain ischemia caused by bilateral carotid occlusion in rats and subsequent reperfusion causes tissue damage, but 1-week DiOHF application has a healing effect on both hippocampus tissue and neurological parameters.PMID:38795755 | DOI:10.1016/j.ejphar.2024.176670 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - May 25, 2024 Category: Drugs & Pharmacology Authors: Tugce Aladag Gozde Acar Rasim Mogulkoc Abdulkerim Kasim Baltaci Source Type: research
Apigenin and baicalein ameliorate thoracic aortic structural deterioration and cognitive deficit via inhibiting AGEs/RAGE/NF- κB pathway in D-galactose-induced aging rats
Eur J Pharmacol. 2024 May 23;976:176660. doi: 10.1016/j.ejphar.2024.176660. Online ahead of print.ABSTRACTApigenin and baicalein are structurally related flavonoids that have been reported to have multiple pharmacological activities. The aim of this study was to investigate the protective effects and potential mechanisms of apigenin and baicalein in D-galactose-induced aging rats. First, apigenin and baicalein showed remarkable antioxidant activity and anti-glycation activity in vitro. Secondly, the protective effects of apigenin and baicalein on aging rats were investigated. We found that apigenin and baicalein supplement...
Source: European Journal of Pharmacology - May 25, 2024 Category: Drugs & Pharmacology Authors: Yufang Ma Zhenming Ma Yiyuan Zhang Chunyun Luo Puxin Huang Jing Tong Hong Ding Honghui Liu Source Type: research
Natriuretic peptide system in hypertension: current understandings of its regulation, targeted therapies and future challenges
Eur J Pharmacol. 2024 May 23:176664. doi: 10.1016/j.ejphar.2024.176664. Online ahead of print.ABSTRACTThe natriuretic peptide system (NPS) is the key driving force of the heart's endocrine function. Recent developments in NPS-targeted therapies have been found promising and effective against cardiovascular diseases, including hypertension. Notably, after discovering crosstalk between NPS and the renin-angiotensin-aldosterone system (RAAS), various combinations such as neprilysin/angiotensin II receptor type 1 AT1 receptor inhibitors and neprilysin/renin inhibitors have been preclinically and clinically tested against vario...
Source: European Journal of Pharmacology - May 25, 2024 Category: Drugs & Pharmacology Authors: Vishwadeep Shelke Neha Dagar Bhupendra Puri Anil Bhanudas Gaikwad Source Type: research
Novel insights into gut health: Cilostazol strengthens gut integrity by adjusting TLR-2/NF- κB/IL-23 and CD44/AKT/GSK-3β/cyclin-D1 trajectories in methotrexate-induced mucositis model
In conclusion, CILO protected gut integrity by reducing the epithelial-mesenchymal transition process, the MTX-induced oxidative, apoptotic, and inflammatory mediators, and turning off the CD44/AKT/GSK-3β/cyclin D1 trajectory and intensifying the expression of PCNA.PMID:38795758 | DOI:10.1016/j.ejphar.2024.176669 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - May 25, 2024 Category: Drugs & Pharmacology Authors: Suzan M Mansour Omar Sabra Fatma El-Komy Kawkab Ahmed Hanan El-Abhar Source Type: research
Corrigendum to "Low-intensity pulsed ultrasound prevents angiotensin II-induced aortic smooth muscle cell phenotypic switch via hampering miR-17-5p and enhancing PPAR- γ" [Eur. J. Pharmacol. 911 (2021):174509]
Eur J Pharmacol. 2024 May 24;975:176662. doi: 10.1016/j.ejphar.2024.176662. Online ahead of print.NO ABSTRACTPMID:38795429 | DOI:10.1016/j.ejphar.2024.176662 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - May 25, 2024 Category: Drugs & Pharmacology Authors: Kun Zhao Tingting Wu Chuanxi Yang Haotian Pan Tianhua Xu Jing Zhang Xiasheng Guo Juan Tu Dong Zhang Xiangqing Kong Bin Zhou Wei Sun Source Type: research
Novel Drug Discovery: Advancing Alzheimer's Therapy through Machine Learning and Network Pharmacology
In conclusion, our study establishes a solid foundation for the use of these drugs in AD therapy. Thus current study highlights the possibility of multi-targeted, synergistic therapeutic approaches in addressing the complex pathophysiology of AD by integrating machine learning, network pharmacology, and molecular docking simulations. This holistic technique not only advances drug development but also opens up new avenues for developing more effective treatments for this difficult and widespread disease.PMID:38795753 | DOI:10.1016/j.ejphar.2024.176661 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - May 25, 2024 Category: Drugs & Pharmacology Authors: Fahad M Alshabrmi Faris F Aba Alkhayl Abdur Rehman Source Type: research
