Biomedical analysis of New Psychoactive Substances (NPS) of natural origin
Publication date: Available online 30 October 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Alfredo Fabrizio Lo Faro, Annagiulia Di Trana, Nunzia La Maida, Adriano Tagliabracci, Raffaele Giorgetti, Francesco Paolo BusardòAbstractNew psychoactive substances (NPS) can be divided into two main groups: synthetic molecules and active principles of natural origin. With respect to this latter group, a wide range of alkaloids contained in plants, mainly from Asia and South America, can be included in the class of NPS of natural origin. The majority NPS of natural origin presents stimulant and/or hallucin...
Source: Journal of Pharmaceutical and Biomedical Analysis - October 31, 2019 Category: Drugs & Pharmacology Source Type: research
Effects of a topical lotion containing aminophylline, caffeine, yohimbe, l ‐carnitine, and gotu kola on thigh circumference, skinfold thickness, and fat mass in sedentary females
ConclusionsA twice ‐daily topical application of Lipoxyderm™ for 28 days compared to a placebo combined with a walking program and a restricted caloric intake is more effective at reducing thigh circumference (1.2 vs 0.8 cm), thigh skinfold thickness (3.7 vs 2.0 mm), and thigh fat mass (100.0 g vs 57.3 g). (Source: Journal of Cosmetic Dermatology)
Source: Journal of Cosmetic Dermatology - November 19, 2018 Category: Dermatology Authors: Guillermo Escalante,
Patrick Bryan,
Juan Rodriguez Tags: ORIGINAL CONTRIBUTION Source Type: research
Prolonged use of pausinystalia yohimbe affects estrus cycle, reproductive hormones and folliculogenesis in rats
This study examined its effects on reproductive hormones and organs, estrus cycle and folliculogenesis in rats. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2018 Category: Reproduction Medicine Authors: L.C. Ajonuma, S.A. Bamiro, S.L. Makanjuola Tags: Poster session Source Type: research
[ASAP] Alkaloids with Immunosuppressive Activity from the Bark of < italic toggle="yes" > Pausinystalia yohimbe < /italic >
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.8b00324 (Source: Journal of Natural Products)
Source: Journal of Natural Products - July 30, 2018 Category: Biochemistry Authors: Ye Liu, Heng-Yi Yu, Hong-Zhe Xu, Jun-Jun Liu, Xiang-Gao Meng, Ming Zhou, Han-Li Ruan Source Type: research
Heart Toxicity Related to Herbs and Dietary Supplements: Online Table of Case Reports. Part 4 of 5.
CONCLUSION: The online "Toxic Table" forewarns clinicians, consumers and the DS industry by listing DS with case reports related to heart toxicity. It may also contribute to Phase IV post marketing surveillance to diminish adverse events that Government officials use to regulate DS.
PMID: 28981338 [PubMed - as supplied by publisher] (Source: Journal of Dietary Supplements)
Source: Journal of Dietary Supplements - October 7, 2017 Category: Nutrition Tags: J Diet Suppl Source Type: research
Adverse effects of prolonged use of pausinystalia yohimbe on sperm and reproductive organs in rats
Pausinystalia yohimbe (P. yohimbe) was first discovered and used by tribes in West Africa, where it grows wild mostly in the Atlantic evergreen forest throughout West Africa from South-east Nigeria to Congo. P. yohimbe bark extract is commonly used as an aphrodisiac among men and for the treatment of erectile dysfunctions. More recently, due to infertility more men have resorted to using P. yohimbe to improve chances of having baby. However, there are no studies on the effects of P. yohimbe on sperm motility and movement characteristics. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2017 Category: Reproduction Medicine Authors: L.C. Ajonuma, S.A. Bamiro, S.L. Makanjuola Tags: Poster session Source Type: research
An Increase in Dietary Supplement Exposures Reported to US Poison Control Centers.
CONCLUSIONS: There was an overall increase in the rate of dietary supplement exposures from 2000 through 2012. Although the majority of these exposures did not require treatment at a health care facility or result in serious medical outcomes, exposures to yohimbe and energy products were associated with considerable toxicity. Our results demonstrate the success of the FDA ban on ma huang products and the need for FDA regulation of yohimbe and energy products in the USA.
PMID: 28741126 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - July 24, 2017 Category: Toxicology Authors: Rao N, Spiller HA, Hodges NL, Chounthirath T, Casavant MJ, Kamboj AK, Smith GA Tags: J Med Toxicol Source Type: research
Assessment of the Authenticity of Herbal Dietary Supplements: Comparison of Chemical and DNA Barcoding Methods
Planta Med DOI: 10.1055/s-0043-107881About 7 % of the U. S. population reports using botanical dietary supplements. Increased use of such supplements has led to discussions related to their authenticity and quality. Reports of adulteration with substandard materials or pharmaceuticals are of concern because such substitutions, whether inadvertent or deliberate, may reduce the efficacy of specific botanicals or lead to adverse events. Methods for verifying the identity of botanicals include macroscopic and microscopic examinations, chemical analysis, and DNA-based methods including DNA barcoding. Macroscopic and microsc...
Source: Planta Medica - April 28, 2017 Category: Drugs & Pharmacology Authors: Pawar, Rahul S. Handy, Sara M. Cheng, Raymond Shyong, Nicole Grundel, Erich Tags: Original Papers Source Type: research
Chromatographic fingerprinting as a strategy to identify regulated plants in illegal herbal supplements.
Abstract
Erectile dysfunction (ED) is a sexual disorder characterized by the inability to achieve or maintain a sufficiently rigid erection. Despite the availability of non-invasive oral treatment options, many patients turn to herbal alternatives. Furthermore, herbal supplements are increasingly gaining popularity in industrialized countries and, as a consequence, quality control is a highly important issue. Unfortunately, this is not a simple task since plants are often crushed and mixed with other plants, which complicates their identification by usage of classical approaches such as microscopy. The aim...
Source: Talanta - January 23, 2017 Category: Chemistry Authors: Custers D, Van Praag N, Courselle P, Apers S, Deconinck E Tags: Talanta Source Type: research
A review of commercially important African medicinal plants
Conclusion Despite a marked recent increase in the number of publications on indigenous medicinal plants and dietary supplements, Africa lags behind Europe and Asia in terms of the number of products that have been commercialised and the percentage of the flora that is utilised for international trade. There is a tremendous potential for developing new crops and new products but much work remains to be done to generate more focussed and relevant pre-clinical data and convincing proof of concept through clinical studies. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 24, 2015 Category: Drugs & Pharmacology Source Type: research
Pharmaceutical quantities of yohimbine found in dietary supplements in the USA
In the USA, botanical dietary supplements are presumed to be safe, but this is not necessarily always the case. Extracts of the evergreen tree yohimbe, Pausinystalia johimbe, though banned in many countries, are sold in hundreds of dietary supplements in the USA. We analyzed 49 brands of supplements labelled as containing yohimbe or yohimbine available for sale from seven major retailers in the USA. Supplements were analyzed using ultra high‐performance liquid chromatography coupled to photodiode and quadrupole time‐of‐flight mass spectrometry detectors for quantity of three alkaloids found in P. johimbe (yohimbine, ...
Source: Drug Testing and Analysis - September 1, 2015 Category: Drugs & Pharmacology Authors: Pieter A. Cohen, Yan‐Hong Wang, Gregory Maller, Renan DeSouza, Ikhlas A. Khan Tags: Short communication Source Type: research
Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acids and energy expenditure in human subjects
Conclusion:
Ingestion of a higenamine-based dietary supplement stimulates lipolysis and energy expenditure, as evidenced by a significant increase in circulating FFA and kilocalorie expenditure. The same supplement results in a moderate increase in heart rate (~3 bpm) and systolic blood pressure (~12 mmHg), which is consistent with previous studies evaluating moderate doses of caffeine and yohimbine, suggesting that higenamine contributes little to the increase in these hemodynamic variables. These findings are in reference to young, healthy and active men and women. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - October 21, 2013 Category: Lipidology Authors: Sang-Rok LeeJohnHenry SchrieferTrint GunnelsInnocence HarveyRichard Bloomer Source Type: research
