Current Trends and Future Directions of Malignancy After kidney Transplantation: A 1970-2022 Bibliometric Analysis
CONCLUSIONS The focus of MKT-related studies has evolved from exploring the spectrum, risk factors, and outcomes of MKT, to examining the pathogenesis, individualized screening, prevention, and treatment, including appropriate use of immune checkpoint inhibitors. Reports of renal transplant recipients infected with SARS-CoV-2 or COVID-19 have also gained attention since 2019. These suggest that individualized management remains a frontier for research and a future direction in MKT topics.PMID:38163947 | DOI:10.12659/AOT.942074 (Source: Cancer Control)
Source: Cancer Control - January 2, 2024 Category: Cancer & Oncology Authors: Fan Jiang Fang Wang Tianyu Zhang Hongmei Dong Hongwei Bai Liping Chen Source Type: research
Current Trends and Future Directions of Malignancy After kidney Transplantation: A 1970-2022 Bibliometric Analysis
CONCLUSIONS The focus of MKT-related studies has evolved from exploring the spectrum, risk factors, and outcomes of MKT, to examining the pathogenesis, individualized screening, prevention, and treatment, including appropriate use of immune checkpoint inhibitors. Reports of renal transplant recipients infected with SARS-CoV-2 or COVID-19 have also gained attention since 2019. These suggest that individualized management remains a frontier for research and a future direction in MKT topics.PMID:38163947 | DOI:10.12659/AOT.942074 (Source: Annals of Transplantation)
Source: Annals of Transplantation - January 2, 2024 Category: Transplant Surgery Authors: Fan Jiang Fang Wang Tianyu Zhang Hongmei Dong Hongwei Bai Liping Chen Source Type: research
Current Trends and Future Directions of Malignancy After kidney Transplantation: A 1970-2022 Bibliometric Analysis
CONCLUSIONS The focus of MKT-related studies has evolved from exploring the spectrum, risk factors, and outcomes of MKT, to examining the pathogenesis, individualized screening, prevention, and treatment, including appropriate use of immune checkpoint inhibitors. Reports of renal transplant recipients infected with SARS-CoV-2 or COVID-19 have also gained attention since 2019. These suggest that individualized management remains a frontier for research and a future direction in MKT topics.PMID:38163947 | DOI:10.12659/AOT.942074 (Source: Annals of Transplantation)
Source: Annals of Transplantation - January 2, 2024 Category: Transplant Surgery Authors: Fan Jiang Fang Wang Tianyu Zhang Hongmei Dong Hongwei Bai Liping Chen Source Type: research
Current Trends and Future Directions of Malignancy After kidney Transplantation: A 1970-2022 Bibliometric Analysis
CONCLUSIONS The focus of MKT-related studies has evolved from exploring the spectrum, risk factors, and outcomes of MKT, to examining the pathogenesis, individualized screening, prevention, and treatment, including appropriate use of immune checkpoint inhibitors. Reports of renal transplant recipients infected with SARS-CoV-2 or COVID-19 have also gained attention since 2019. These suggest that individualized management remains a frontier for research and a future direction in MKT topics.PMID:38163947 | PMC:PMC10771012 | DOI:10.12659/AOT.942074 (Source: Annals of Transplantation)
Source: Annals of Transplantation - January 2, 2024 Category: Transplant Surgery Authors: Fan Jiang Fang Wang Tianyu Zhang Hongmei Dong Hongwei Bai Liping Chen Source Type: research
Current Trends and Future Directions of Malignancy After kidney Transplantation: A 1970-2022 Bibliometric Analysis
CONCLUSIONS The focus of MKT-related studies has evolved from exploring the spectrum, risk factors, and outcomes of MKT, to examining the pathogenesis, individualized screening, prevention, and treatment, including appropriate use of immune checkpoint inhibitors. Reports of renal transplant recipients infected with SARS-CoV-2 or COVID-19 have also gained attention since 2019. These suggest that individualized management remains a frontier for research and a future direction in MKT topics.PMID:38163947 | PMC:PMC10771012 | DOI:10.12659/AOT.942074 (Source: Annals of Transplantation)
Source: Annals of Transplantation - January 2, 2024 Category: Transplant Surgery Authors: Fan Jiang Fang Wang Tianyu Zhang Hongmei Dong Hongwei Bai Liping Chen Source Type: research
Current Trends and Future Directions of Malignancy After kidney Transplantation: A 1970-2022 Bibliometric Analysis
CONCLUSIONS The focus of MKT-related studies has evolved from exploring the spectrum, risk factors, and outcomes of MKT, to examining the pathogenesis, individualized screening, prevention, and treatment, including appropriate use of immune checkpoint inhibitors. Reports of renal transplant recipients infected with SARS-CoV-2 or COVID-19 have also gained attention since 2019. These suggest that individualized management remains a frontier for research and a future direction in MKT topics.PMID:38163947 | PMC:PMC10771012 | DOI:10.12659/AOT.942074 (Source: Annals of Transplantation)
Source: Annals of Transplantation - January 2, 2024 Category: Transplant Surgery Authors: Fan Jiang Fang Wang Tianyu Zhang Hongmei Dong Hongwei Bai Liping Chen Source Type: research
GSE202361 Neoadjuvant immune checkpoint blockade in retroperitoneal dedifferentiated liposarcoma and extremity/trunk undifferentiated pleomorphic sarcoma (NCT03307616)
Contributors : Christina L Roland ; Chia C Wu ; Elise F Nassif ; Emily Z KeungSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecent evidence suggests that immune checkpoint blockade (ICB) has some activity in metastatic dedifferentiated liposarcoma (DDLPS) and undifferentiated pleomorphic sarcoma (UPS). We conducted a randomized, non-comparative phase 2 trial (NCT03307616) of nivolumab or nivolumab/ipilimumab in patients with resectable retroperitoneal DDLPS (n=17) and extremity/truncal UPS (n=10), with UPS patients receiving concurrent radiation therapy. The primary endpoint of path...
Source: GEO: Gene Expression Omnibus - January 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
A Rare Mesothelioma Under The Cloak Of Heart Failure And Constrictive Pericarditis
We present a case of PPM treated with Nivolumab plus ipilimumab. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Muhammad Osama, Venkata Satish Pendela, Vishal Parikh Tags: 198 Source Type: research
Systemic Therapy for Melanoma Brain and Leptomeningeal Metastases
Opinion statementMelanoma has a high propensity to metastasize to the brain which portends a poorer prognosis. With advanced radiation techniques and targeted therapies, outcomes however are improving. Melanoma brain metastases are best managed in a multi-disciplinary approach, including medical oncologists, neuro-oncologists, radiation oncologists, and neurosurgeons. The sequence of therapies is dependent on the number and size of brain metastases, status of systemic disease control, prior therapies, performance status, and neurological symptoms. The goal of treatment is to minimize neurologic morbidity and prolong both p...
Source: Current Treatment Options in Oncology - December 30, 2023 Category: Cancer & Oncology Source Type: research
Immune checkpoint inhibitors and cancer immunotherapy by aptamers: an overview
AbstractEfforts in cancer immunotherapy aim to counteract evasion mechanisms and stimulate the immune system to recognise and attack cancer cells effectively. Combination therapies that target multiple aspects of immune evasion are being investigated to enhance the overall efficacy of cancer immunotherapy. PD-1 (Programmed Cell Death Protein 1), CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4), LAG-3 (Lymphocyte-Activation Gene 3), and TIM-3 (T Cell Immunoglobulin and Mucin Domain-Containing Protein3) are all immune checkpoint receptors that play crucial roles in regulating the immune response and maintaining self-tolerance often...
Source: Medical Oncology - December 29, 2023 Category: Cancer & Oncology Source Type: research
Evaluation of mycophenolic acid exposure in a patient with immune-related hepatotoxicity caused by nivolumab and ipilimumab therapy for malignant melanoma: a case report
ConclusionOur patient did not exceed the upper limit of MPA levels as an index of the onset of side effects of kidney transplantation and achieved rapid improvement in liver function. Prompt initiation of MMF after assessment of the steroid effect leads to adequate MPA exposure. Therapeutic drug monitoring should be considered when MMF is administered, to avoid overexposure. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - December 26, 2023 Category: Cancer & Oncology Source Type: research
Short-chain fatty acids (SCFAs) from gastrointestinal disorders, metabolism, epigenetics, central nervous system to cancer - A mini-review
Chem Biol Interact. 2023 Dec 23:110851. doi: 10.1016/j.cbi.2023.110851. Online ahead of print.ABSTRACTShort-chain fatty acids (SCFAs), generated through microbial fermentation of dietary fibers and proteins in the gut, play a pivotal role in maintaining intestinal integrity, cellular function, and the immune response. SCFAs, including butyrate, acetate, and propionate, are absorbed in the colon or excreted through feces, contributing to essential physiological processes. Butyrate, a primary energy source for colonocytes, exhibits anti-inflammatory properties and regulates key pathways, such as nuclear factor-κB (NF-κB) i...
Source: Chemico-Biological Interactions - December 25, 2023 Category: Molecular Biology Authors: Khalid A Abdelhalim Source Type: research
Short-chain fatty acids (SCFAs) from gastrointestinal disorders, metabolism, epigenetics, central nervous system to cancer - A mini-review
Chem Biol Interact. 2023 Dec 23:110851. doi: 10.1016/j.cbi.2023.110851. Online ahead of print.ABSTRACTShort-chain fatty acids (SCFAs), generated through microbial fermentation of dietary fibers and proteins in the gut, play a pivotal role in maintaining intestinal integrity, cellular function, and the immune response. SCFAs, including butyrate, acetate, and propionate, are absorbed in the colon or excreted through feces, contributing to essential physiological processes. Butyrate, a primary energy source for colonocytes, exhibits anti-inflammatory properties and regulates key pathways, such as nuclear factor-κB (NF-κB) i...
Source: Chemico-Biological Interactions - December 25, 2023 Category: Molecular Biology Authors: Khalid A Abdelhalim Source Type: research
Immune checkpoint inhibitor-related myositis and myocarditis: diagnostic pitfalls and imaging contribution in a real-world, institutional case series
ConclusionMyositis is a potentially severe irAE. Despite its heterogeneous presentation, some highly suggestive clinical symptoms, such as ocular involvement, or radiological signs should raise physicians ’ attention to avoid misdiagnosis. We thus recommend a multidisciplinary assessment (including complete neuromuscular evaluation) even in case of isolated myocarditis. Our series underlines the importance of an early diagnosis, since suspension of ICI and adequate treatment are usually associated with good functional outcome. (Source: Journal of Neurology)
Source: Journal of Neurology - December 23, 2023 Category: Neurology Source Type: research
Exploring a Rarity: Incidence of and Therapeutic Approaches for Neurological Complications and Hypophysitis in Cancer Patients on Immune Checkpoint Inhibitors-A Single-Center Study
Curr Oncol. 2023 Dec 18;30(12):10509-10518. doi: 10.3390/curroncol30120766.ABSTRACTImmune checkpoint inhibitors, such as anti-PD-1 and anti-CTLA-4 inhibitors, have become the standard of care for many cancer types. However, they induce immune-related adverse events (irAEs), including neurotoxicity and hypophysitis. The incidence and outcomes of neurotoxicity and hypophysitis in patients treated with immune checkpoint inhibitors are not well established. We conducted a retrospective study of 812 patients with solid cancers who received immune checkpoint inhibitors at the University General Hospital of Ioannina between Janua...
Source: Current Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Anna Lea Amylidi Aristeidis Gogadis Melina Yerolatsite George Zarkavelis Nanteznta Torounidou Varvara Keramisanou Eleftherios Kampletsas Davide Mauri Source Type: research
