TWiV 843: COVID-19 clinical update #93 with Dr. Daniel Griffin
In COVID-19 clinical update #93, Dr. Griffin summarizes Omicron fitness, S-gene target failure, monoclonal efficacy against Omicron, vaccination, monoclonals, and disease in children, persistence of memory B cells in the elderly, infection and vaccine induced immunity, protection against severe illness and death by a third mRNA vaccine dose, high flow oxygen versus intubation, and therapeutic anticoagulation. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variant updates (CDC) List of diagnostic kits (Global Fund, pd...
Source: This Week in Virology - MP3 Edition - December 18, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Coronapod: Omicron - your questions answered
Several weeks after the Omicron variant was first identified, it has quickly spread across the world. Early data are showing clear signals that the latest variant of concern is able to evade immunity and spread at a rate faster than any other variant to date. But many questions remain unanswered about the severity of infection, the protection afforded by natural and vaccine-derived immunity, and the impact Omicron could have on the global pandemic response. In this episode, we delve into the very latest studies to take stock of where we are so far and, in a Coronapod first, take on questions sent in by ...
Source: Nature Podcast - December 17, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
Coronapod: Omicron - your questions answered
Several weeks after the Omicron variant was first identified, it has quickly spread across the world. Early data are showing clear signals that the latest variant of concern is able to evade immunity and spread at a rate faster than any other variant to date. But many questions remain unanswered about the severity of infection, the protection afforded by natural and vaccine-derived immunity, and the impact Omicron could have on the global pandemic response. In this episode, we delve into the very latest studies to take stock of where we are so far and, in a Coronapod first, take on questions sent in by ...
Source: Nature Podcast - December 17, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
TWiV 842: The clot thickens
TWiV reviews the results of serum neutralization assays which show that a third vaccine dose restores neutralization of the Omicron variant, and interaction of platelet factor 4 with the adenovirus capsid, suggesting a mechanism for thrombosis with thrombocytopenia syndrome. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Third vaccine dose improves Omicron neutralization (medRxiv) ChAdOX1 interacts with PF4 (Sci Adv) Timestamps by Jolene. Thanks! Weekly Picks Brianne – Vaccine Scientists: Time’s ...
Source: This Week in Virology - MP3 Edition - December 16, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Pluto's strange ice patterns explained by new theory
An explanation for giant ice structures on Pluto, and dismantling the mestizo myth in Latin American genetics.In this episode:00:46 The frozen root of Pluto’s polygonal patternsIn 2015, NASA’s New Horizons probe sent back some intriguing images of Pluto. Huge polygonal patterns could be seen on the surface of a nitrogen-ice ice filled basin known as Sputnik Planitia. This week, a team put forward a new theory to explain these perplexing patterns.Research article: Morison et al.06:15 Research HighlightsHow Pamplona’s bull-running defies the dynamics of crowd motion, and self-healing microbial bio-bricks.Research Highl...
Source: Nature Podcast - December 15, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
Pluto's strange ice patterns explained by new theory
An explanation for giant ice structures on Pluto, and dismantling the mestizo myth in Latin American genetics.In this episode:00:46 The frozen root of Pluto’s polygonal patternsIn 2015, NASA’s New Horizons probe sent back some intriguing images of Pluto. Huge polygonal patterns could be seen on the surface of a nitrogen-ice ice filled basin known as Sputnik Planitia. This week, a team put forward a new theory to explain these perplexing patterns.Research article: Morison et al.06:15 Research HighlightsHow Pamplona’s bull-running defies the dynamics of crowd motion, and self-healing microbial bio-bricks.Research Highl...
Source: Nature Podcast - December 15, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
TWiV 840: COVID-19 clinical update #92 with Dr. Daniel Griffin
In COVID-19 clinical update #92, Dr. Griffin reviews emerging data on the Omicron variant, much information about monoclonal antibody treatment, including expansion of EUA for Lilly’s cocktail, FDA EUA for pre-exposure prophylaxis, outcomes after treatment, and investigation of subcutaneous or intramuscular administration; effect of adding immunomodulatory agents to usual care on thromboembolic events, and long COVID following infection in previously vaccinated individuals. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this ep...
Source: This Week in Virology - MP3 Edition - December 11, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Coronapod: vaccines and long COVID, how protected are you?
Vaccines significantly reduce the risk of developing COVID-19, but scientists are now asking what effect the vaccines might have on long COVID. Long COVID is a somewhat ill-defined, but common, syndrome that can arise from even mild cases of COVID19 - with symptoms ranging from chronic fatigue to breathing difficulties and even neurological deficiency. But little is known about what triggers long COVID, or how to prevent it. As public health experts consider protection measures, the role of vaccines in protecting against long COVID is poorly understood, and although numerous studies are seeking answers, they are turning up...
Source: Nature Podcast - December 10, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
Coronapod: vaccines and long COVID, how protected are you?
Vaccines significantly reduce the risk of developing COVID-19, but scientists are now asking what effect the vaccines might have on long COVID. Long COVID is a somewhat ill-defined, but common, syndrome that can arise from even mild cases of COVID19 - with symptoms ranging from chronic fatigue to breathing difficulties and even neurological deficiency. But little is known about what triggers long COVID, or how to prevent it. As public health experts consider protection measures, the role of vaccines in protecting against long COVID is poorly understood, and although numerous studies are seeking answers, they are turning up...
Source: Nature Podcast - December 10, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
TWiV 839: The long and the short of it: get vaccinated
TWiV reviews the impact of vaccination on SARS-CoV-2, the latest information on Omicron, West Nile virus transmission by organ transplantation, and why a 16 week interval between doses of BNT162b2 vaccine is better than a shorter interval. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronavirus in the US (NY Times) Omicron variant (NY Times) West Nile virus transmission by organ transplantation (Emerg Inf Dis) Stronger antibody response after 16 week mRNA dose (Cell Host Micr) Higher antib...
Source: This Week in Virology - MP3 Edition - December 9, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 837: COVID-19 clinical update #91 with Dr. Daniel Griffin
In COVID-19 clinical update #91, Dr. Griffin discusses final results of molnupiravir trial, Omicron variant of concern, outcomes in B-cell depleted patients, recovery in T-cell depleted macaques, peptide for induction of T cell immunity, high respiratory viral RNA loads in infants, IgA and T cells transferred to breast milk after vaccination, sensitivity and specificity of ID NOW, post-acute sequelae at 12 months, disease in low and middle income countries. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Update on Mol...
Source: This Week in Virology - MP3 Edition - December 4, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Coronapod: How has COVID impacted mental health?
Studying mental health in populations is not a simple task, but as the pandemic has continued, mounting concerns have mobilised researchers.Now, researchers have used data from helplines in 20 countries to assess the impacts that COVID, as well as associated political and public health measures like financial assistance programs and lockdowns, have had on mental health. Contrary to expectations, loneliness and concerns about the impacts of the pandemic drove most of the callers, rather than imminent threats such as suicidal thoughts or abuse.News: Millions of helpline calls reveal how COVID affected mental healthOmicr...
Source: Nature Podcast - December 3, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
Coronapod: How has COVID impacted mental health?
Studying mental health in populations is not a simple task, but as the pandemic has continued, mounting concerns have mobilised researchers.Now, researchers have used data from helplines in 20 countries to assess the impacts that COVID, as well as associated political and public health measures like financial assistance programs and lockdowns, have had on mental health. Contrary to expectations, loneliness and concerns about the impacts of the pandemic drove most of the callers, rather than imminent threats such as suicidal thoughts or abuse.News: Millions of helpline calls reveal how COVID affected mental healthOmicr...
Source: Nature Podcast - December 3, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
TWiV 835: Giving thanks for antibodies
TWiV reviews why children should be vaccinated against COVID-19, increased risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated but not recovered individuals, and immune correlates of protection from the mRNA-1273 vaccine efficacy trial. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 vaccines for children (Science) Risk of infection with variants (medRxiv) Immune correlates of mRNA-1273 (Science) Letters read on TWiV 835 Timestamps by J...
Source: This Week in Virology - MP3 Edition - November 28, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 834: COVID-19 clinical update #90 with Dr. Daniel Griffin
In COVID-19 clinical update #90, Dr. Griffin covers FDA expansion for booster doses, 3 more at home antigen tests approved by FDA, immune correlates analysis of mRNA-1273 vaccine, risk for stillbirth, PROVENT prophylaxis trial results, fluvoxamine recommendations, advice on molnupiravir, automated text messaging service for monitoring illness, and long COVID-19 after vaccination and infection. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Expanded eligibility for booster doses (FDA) More rapid antigen tests approved...
Source: This Week in Virology - MP3 Edition - November 27, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
