TWiV 834: COVID-19 clinical update #90 with Dr. Daniel Griffin

In COVID-19 clinical update #90, Dr. Griffin covers FDA expansion for booster doses, 3 more at home antigen tests approved by FDA, immune correlates analysis of mRNA-1273 vaccine, risk for stillbirth, PROVENT prophylaxis trial results, fluvoxamine recommendations, advice on molnupiravir, automated text messaging service for monitoring illness, and long COVID-19 after vaccination and infection. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Expanded eligibility for booster doses (FDA) More rapid antigen tests approved (FDA) Immune correlates for mRNA-1273 (Science) Risk for still birth with and without COVID-19 (MMWR) PROVENT phase III prophylaxis trial (AstraZenica) Fluvoxamine guidelines (IDSA) COVID-OUT trial (Univ Minnesota) Monoclonal antibody treatment in vaccinated infected (J Inf Dis) Steroid use in non-oxygen requiring patients (QJM) Doxycycline trial (Lancet) Efficacy of inhaled ciclesonide (JAMA) Advise on use of molnupiravir (EMA) Text messaging for monitoring disease (Ann Int Med) Long COVID after vaccination and infection (Res Square) Ivermectin for West Nile virus (Medpage Today) Letters read on TWiV 834 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts

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TWiV reviews the impact of vaccination on SARS-CoV-2, the latest information on Omicron, West Nile virus transmission by organ transplantation, and why a 16 week interval between doses of BNT162b2 vaccine is better than a shorter interval. Click arrow to playDownload TWiV 839 (64 MB .mp3, 107 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology antibody coronavirus COVID-19 pandemic SARS-CoV-2 vaccine viral viruses Source Type: blogs
Before COVID-19 two recent pandemics were notably associated with infectious and para-infectious neuromuscular sequelae, including associations between acute flaccid myelitis (AFM) and West Nile Virus, and Guillain Barr é Syndrome (GBS) and Zika virus (ZIKV). Yet, despite origins in sub-Saharan Africa (SSA), there is no evidence that these diseases, or other arboviruses for that matter, cause neurologic morbidity in the sub-continent. In the case of ZIKV, an argument has been made for newly acquired neurovirulence through viral evolution into African and Asian lineages, but weak healthcare systems and poor ability t...
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
Mass treatment with ivermectin, a drug that has become controversial during the COVID-19 pandemic, eliminates river blindness transmission and can reduce spread of West Nile virus, according to new findings.
Source: Health News - - Category: Consumer Health News Source Type: news
Biochem Biophys Res Commun. 2021 Oct 19;583:14-21. doi: 10.1016/j.bbrc.2021.10.042. Online ahead of print.ABSTRACTCOVID-19 pandemic has a major effect on world health, particularly on individuals suffering from severe diseases or old aged persons. Various case studies revealed that COVID-19 might increase the progression of Parkinson's disease (PD). Coxsackievirus, dengue virus Epstein-Barr virus, hepatitis C virus, Japanese encephalitis, Western equine encephalomyelitis virus, West Nile virus, and human immunodeficiency virus have all been linked to the development of transient or permanent parkinsonism, owing to the indu...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Source Type: research
These two fatal cases of West Nile Virus underscore the importance of remaining vigilant regarding the possibility of other serious viral diseases in the differential diagnosis.Journal of the American Board of Family Medicine
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news
MRI reveals brain changes in adults with herpes simplex encephalitis that ar...Read more on AuntMinnie.comRelated Reading: ECR 2020: COVID-19's nonpulmonary manifestations Researchers outline neurological signs of COVID-19 Brain MRI shows long-term adverse effects of West Nile virus MRI finds something fishy in outbreak of brain infections Creutzfeldt-Jakob disease on MRI often missed by radiologists
Source: Headlines - Category: Radiology Source Type: news
The ever-evolving pandemic of Coronavirus disease 2019 (COVID-19) has the potential to drown out other viruses continuing to infect communities. To highlight this, we present 2 cases of fatal West Nile virus neuroinvasive disease that occurred within 2 weeks of each other. Since the first positive case of West Nile virus in the United States, there have been 2 epidemics in the past 2 decades, most often occurring in regions of North Texas and Southern California, which have been areas of high-incidence for COVID-19. It is important for the health care provider to recognize diagnostic biases and maintain broad differentials...
Source: Journal of the American Board of Family Medicine - Category: Primary Care Authors: Tags: Research Letter Source Type: research
In conclusion, airway pressure treatment and adherence are independently associated with lower odds of incident AD diagnoses in older adults. Results suggest that treatment of OSA may reduce risk of subsequent dementia.
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The decline of the immune system is of great importance in aging. Vulnerability to infection, a decreased surveillance of senescent cells and cancerous cells, and growing chronic inflammation all take their toll. A sizable fraction of this problem stems from the diminished supply of new T cells of the adaptive immune system. T cells begin life as thymocytes in the bone marrow, then migrate to the thymus where they mature. Unfortunately, the thymus atrophies with age, a process known as thymic involution, in which active tissue is replaced by fat. The T cell supply falters, and as a result the existing T cell population bec...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
We present a fatal case of West Nile virus meningoencephalomyelitis initially misdiagnosed as COVID-19 in a 63-year-old Egyptian woman with a previous diagnosis of systemic lupus erythematosus. The patient's medical history and immunosuppressive therapy, as well as the COVID-19 pandemic, substantially broadened the differential diagnosis of her encephalitis.PMID:33782207 | DOI:10.4269/ajtmh.21-0041
Source: Am J Trop Med Hyg - Category: Infectious Diseases Authors: Source Type: research
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