TWiV 899: COVID-19 clinical update #114 with Dr. Daniel Griffin
In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Effects of early treatment with Ivermectin (NEJM) Procalcitonin not a reliable biomarker (IDSA) Evaluation of vaccine in children 6 t...
Source: This Week in Virology - MP3 Edition - May 14, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Fixing fat bubbles for vaccines, and preventing pain from turning chronic
On this week’s show: Lipid nanoparticles served us well as tiny taxis delivering millions of mRNA vaccines against COVID-19, but they aren’t optimized—yet, and why we might need inflammation to stop chronic pain
The messenger RNA payload of the mRNA vaccines against SARS-CoV-2 is wrapped up in little fatty packets called lipid nanoparticles (LNPs). These fat bubbles were originally designed for something much different—carrying molecules into cells to silence genes. But they were useful and we were in a hurry, so not much was changed about them when they were pressed into service against COVID-19. ...
Source: Science Magazine Podcast - May 12, 2022 Category: Science Authors: Science Magazine Source Type: podcasts
Fixing fat bubbles for vaccines, and preventing pain from turning chronic
On this week’s show: Lipid nanoparticles served us well as tiny taxis delivering millions of mRNA vaccines against COVID-19, but they aren’t optimized—yet, and why we might need inflammation to stop chronic pain
The messenger RNA payload of the mRNA vaccines against SARS-CoV-2 is wrapped up in little fatty packets called lipid nanoparticles (LNPs). These fat bubbles were originally designed for something much different—carrying molecules into cells to silence genes. But they were useful and we were in a hurry, so not much was changed about them when they were pressed into service against COVID-19. Science journali...
Source: Science Magazine Podcast - May 12, 2022 Category: Science Authors: Science Magazine Source Type: podcasts
TWiV 898: Immunity is skin deep
TWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Herd immunity may not apply to COVID-19 (J Inf Dis) Smallpox vaccination increases skin bacteria (PLoS Path) The invinceable TWiV (TWiV 145) By the pricking of my thumbs… (TWiV 284) Letters read on TWiV 898 Timestamps b...
Source: This Week in Virology - MP3 Edition - May 8, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 897: COVID-19 clinical update #113 with Dr. Daniel Griffin
In COVID-19 clinical update #113, Dr. Griffin discusses tocilizumab use in hospitalized Patients, IL-6 inhibitors and mortality, Baricitinib in hospitalized patients, post-infection neurological sequelae, comparative effectiveness of Pfizer and Moderna vaccines, phase 2/3 study of Paxlovid, infection relapse following Paxlovid, pre-hospital administration of Remdesivir, and hospitalization with different variants. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Timing of Tocilizumab Use in Hospitalized Patients (NIH) Interleukin-6 inhibitors redu...
Source: This Week in Virology - MP3 Edition - May 7, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Q & A With FDA Commissioner Robert Califf
After serving as commissioner of the US Food and Drug Administration (FDA) under President Obama, Robert M. Califf, MD, recently returned to the role, overseeing a critical federal agency that regulates food, drugs, therapeutics, and medical devices in the US. In a wide-ranging discussion with JAMA Deputy Editor Gregory Curfman, MD, Califf discusses COVID-19 vaccine modifications, the FDA’s approach to evaluating evidence, and efforts to combat health misinformation. Recorded April 26, 2022. Related Content: (Source: JAMA Author Interviews)
Source: JAMA Author Interviews - May 4, 2022 Category: General Medicine Authors: JAMA Network Source Type: podcasts
TWiV 896: Memory B cells, the way we were
TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost. Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Climate change and viral zoonosis risk (Nature) COVID-19 mRNA boost effect on memory B cells (Nature) Letters read on TWiV 896 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Toots Thilelemans Amy – Largest comet ever identified Vincent – Sc...
Source: This Week in Virology - MP3 Edition - May 1, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 895: COVID-19 clinical update #112 with Dr. Daniel Griffin
In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Seroprevalence of Infection-Induced Antibodies (CDC) Authorization for Vaccine in Young Children Filed (Moderna) Public Health Impact of Vaccines in US (BMJ) FDA authorizes first approved t...
Source: This Week in Virology - MP3 Edition - April 30, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Using quantum tools to track dark matter, why rabies remains, and a book series on science and food
On this week’s show: How physicists are using quantum sensors to suss out dark matter, how rabies thwarts canine vaccination campaigns, and a kickoff for our new series with authors of books on food, land management, and nutrition science
Dark matter hunters have turned to quantum sensors to find elusive subatomic particles that may exist outside physicists’ standard model. Adrian Cho, a staff writer for Science, joins host Sarah Crespi to give a tour of the latest dark matter particle candidates—and the traps that physicists are setting for them.
Next, we hear from Katie Hampson, a professor in the Ins...
Source: Science Magazine Podcast - April 28, 2022 Category: Science Authors: Science Magazine Source Type: podcasts
Using quantum tools to track dark matter, why rabies remains, and a book series on science and food
On this week’s show: How physicists are using quantum sensors to suss out dark matter, how rabies thwarts canine vaccination campaigns, and a kickoff for our new series with authors of books on food, land management, and nutrition science
Dark matter hunters have turned to quantum sensors to find elusive subatomic particles that may exist outside physicists’ standard model. Adrian Cho, a staff writer for Science, joins host Sarah Crespi to give a tour of the latest dark matter particle candidates—and the traps that physicists are setting for them.
Next, we hear from Katie Hampson, a professor in the Institute of Bi...
Source: Science Magazine Podcast - April 28, 2022 Category: Science Authors: Science Magazine Source Type: podcasts
TWiV 893: Yellow fever virus escapes antibodies
Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guests: Kartik Chandran, Denise Haslwanter, and Gorka Lasso Cabrera Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Prometheus project (TWiV 578) Reduced neutralization of South American yellow fever virus (Cell Host Microbe) Letters read on TW...
Source: This Week in Virology - MP3 Edition - April 24, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 892: COVID-19 clinical update #111 with Dr. Daniel Griffin
In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine coverage and mortality, Hong Kong (MMWR) Kids behind on routine vaccinations (Politico) Immune response to booster, 5-11 year olds (Pfizer) Children and vaccination (AAP) Hospitalization of 5-11 year olds (MMWR) Test usin...
Source: This Week in Virology - MP3 Edition - April 23, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Reducing “COVID-19 Misinformation” While Preserving Free Speech
Misinformation about COVID-19 (such as around vaccines, masks, and ineffective drugs) has circulated widely during the pandemic, and much of this misinformation is protected by the Free Speech Clause of the First Amendment. Professor of Surgery and Perioperative Care and Professor of Law William M. Sage, MD, JD, from the University of Texas at Austin, is interviewed in this JAMA podcast. Related Content: Reducing “COVID-19 Misinformation” While Preserving Free Speech (Source: JAMA Author Interviews)
Source: JAMA Author Interviews - April 19, 2022 Category: General Medicine Authors: JAMA Network Source Type: podcasts
Corticosteroids for Duchenne Muscular Dystrophy, Pregnancy Outcomes After SARS-CoV-2 Vaccination, Association of Race and Ethnicity With Dementia, and more
Editor's Summary by Linda Brubaker, MD, Associate Editor of JAMA, the Journal of the American Medical Association, for the April 19, 2022 issue. (Source: JAMA: This Week's Audio Commentary)
Source: JAMA: This Week's Audio Commentary - April 19, 2022 Category: General Medicine Authors: JAMA Network Source Type: podcasts
TWiV 890: Looking into a booster crystal ball
This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode What next for COVID-19 boosters? (NEJM) Boosting with historical or variant mRNA vaccines (Cell) Vaccination-infection interval determines antibody breadth (Ce...
Source: This Week in Virology - MP3 Edition - April 17, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
