TWiV 862: COVID-19 clinical update #100 with Dr. Daniel Griffin
In COVID-19 clinical update #100, Daniel Griffin, from Accra, Ghana, reviews the challenges in evaluating Omicron severity, over 800 deaths in children, Pfizer vaccine EUA application for under 5 year olds, false positives from soft drinks, Novavax vaccine EUA application, childhood experiences and vaccine hesitancy, fourth vaccine dose in Israel, effects of antivirals and monoclonals against Omicron, and multiple factors associated with PASC. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Omicron severity challenges (NEJM) Children and COVID data (AAP) ...
Source: This Week in Virology - MP3 Edition - February 5, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 861: Rough draft of Omicron origins
Nels joins TWiV to discuss hypotheses for the origins of Omicron, including that it came from mice or arose during chronic infection of an immunocompromised patient. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Nels Elde Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Columbia University BSL-3 Manager position Did Omicron come from mice? (J Genet Genomics) Persistent SARS-CoV-2 infection (SSRN) Letters read on TWiV 861 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Groundhogs Emerge Fro...
Source: This Week in Virology - MP3 Edition - February 4, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 860: Evading a Toll on the road to RNA vaccines
TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA vaccines. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Columbia University BSL-3 Manager position RNA modifications suppress innate recognition (Immunity) Critical contribution of pseudouridine (Front Cell Dev Biol) Rich Condit reminisces (YouTube) Letters read ...
Source: This Week in Virology - MP3 Edition - January 30, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 859: COVID-19 clinical update #99 with Dr. Daniel Griffin
In COVID-19 clinical update #99, Daniel Griffin discusses Omicron disease severity, neurologic manifestations in children, testing outcomes during multiple infections, boosters improve VE and VD, booster efficacy for ED and UC encounters, vaccines induce cross-protective T cell memory, and indications for monoclonal antibody therapy.C Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Omicron disease severity (MMWR) Neurologic manifestations in children (Pediatric Neurol) Respiratory virus interference (Emerg Inf Dis) Hospitalization by vaccination status (C...
Source: This Week in Virology - MP3 Edition - January 29, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 858: The vax of life with John Mascola
John Mascola joins TWiV to discuss the history and mission of the NIH Vaccine Research Center, how it prepared for devising pandemic vaccines, and development of the COVID-19 vaccines. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Guest: John Mascola Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Accelerated COVID-19 vaccine development (Immunity) Letters read on TWiV 858 Timestamps by Jolene. Thanks! Weekly Picks Brianne – How Sesame Street is Handling the Pandemic Rich – Zamboni: How it works Alan – How lightning starts V...
Source: This Week in Virology - MP3 Edition - January 28, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Talk Evidence - isolation periods, openness, and environmental impacts
In the first Talk Evidence of 2022, we'll be asking about the evidence for isolation - now that isolation periods are being reduced, or even stopped in the event of a negative lateral flow test, we'll find out what data that's based on, and if it's appropriate.
Vaccinations and treatments for covid-19 have been the one major success story of the pandemic, but that doesn't mean we should abandon the principles of openness and transparency when it comes to scrutinising the data - we'll hear what access to the data which underlies regulatory approval could do now.
Finally, the impacts of climate change were set out in a WH...
Source: The BMJ Podcast - January 28, 2022 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts
Talk Evidence - isolation periods, openness, and environmental impacts
In the first Talk Evidence of 2022, we'll be asking about the evidence for isolation - now that isolation periods are being reduced, or even stopped in the event of a negative lateral flow test, we'll find out what data that's based on, and if it's appropriate.
Vaccinations and treatments for covid-19 have been the one major success story of the pandemic, but that doesn't mean we should abandon the principles of openness and transparency when it comes to scrutinising the data - we'll hear what access to the data which underlies regulatory approval could do now.
Finally, the impacts of climate change were set out in a WH...
Source: The BMJ Podcast - January 28, 2022 Category: General Medicine Authors: BMJ Group Source Type: podcasts
Myocarditis After mRNA-Based COVID-19 Vaccination, Third Dose of BNT161b2 Vaccine and SARS-CoV-2 Infection Incidence, Penetrance of Deleterious Clinical Variants, and more
Editor's Summary by Kristin Walter, MD, Associate Editor of JAMA, the Journal of the American Medical Association, for the January 25, 2022 issue. (Source: JAMA: This Week's Audio Commentary)
Source: JAMA: This Week's Audio Commentary - January 25, 2022 Category: General Medicine Authors: JAMA Network Source Type: podcasts
TWiV 857: Not just antibody, Jon Yewdell
Jon Yewdell returns to TWiV to discuss how antibodies are made, vaccination against SARS-CoV-2, antigenic variation of the virus, booster shots, and more. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guest: Jon Yewdell Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Jon Yewdell on TWiV 208, 467, 597, 620 Letters read on TWiV 857 Timestamps by Jolene. Thanks! Weekly Picks Jon – The Premonition by Michael Lewis Dickson – Nature photographer of the year 2021 Brianne – Should BioBank Volunteers Be Warned About Mutations? Rich ...
Source: This Week in Virology - MP3 Edition - January 23, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 856: COVID-19 clinical update #98 with Dr. Daniel Griffin
In COVID-19 clinical update #98, Daniel Griffin reviews COVID-19 in South Africa, recognition of Omicron by ancestral T cells, booster effectiveness against disease, infection and vaccination in pregnant women, early Remdesivir to prevent progression to severe disease, management of hospitalized adults, Tocilizumab in hospitalized patients, vaccination and long COVID, and the true toll of the pandemic. Click arrow to play Download TWiV 853 (58 MB .mp3, 48 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 in South Africa (pdf) Ancestral T cells recogn...
Source: This Week in Virology - MP3 Edition - January 22, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 855: T time with Alessandro Sette
Alessandro Sette returns to TWiV to discuss the observation that SARS-CoV-2 vaccination induces T cells that are able to cross-recognize variants Alpha to Omicron. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Alessandro Sette Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Travel Award Applications (ASV) 3:20 Impact of variants on T cells (Cell Rep Med) Timestamps by Jolene. Thanks! Letters read on TWiV 855 Weekly Picks Brianne – 75 years of research on human diseases in 1 minute Kathy – 10 second video of COVID-19 spread...
Source: This Week in Virology - MP3 Edition - January 21, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Why mutation is not as random as we thought
Challenging the dogma of gene evolution, and how chiral nanoparticles could give vaccines a boost.In this episode:00:45 Genome mutations may be less random than previously thoughtA long-standing doctrine in evolution is that mutations can arise anywhere in a genome with equal probability. However, new research is challenging this idea of randomness, showing that mutations in the genome of the plant Arabidosis thaliana appear to happen less frequently in important regions of the genome.Research article: Munroe et al.News and Views: Important genomic regions mutate less often than do other regions13:45 Research Hig...
Source: Nature Podcast - January 19, 2022 Category: Science Authors: Springer Nature Limited Source Type: podcasts
Why mutation is not as random as we thought
Challenging the dogma of gene evolution, and how chiral nanoparticles could give vaccines a boost. See acast.com/privacy for privacy and opt-out information. (Source: Nature Podcast)
Source: Nature Podcast - January 19, 2022 Category: Science Authors: Springer Nature Limited Source Type: podcasts
TWiV 854: Omicron is evasive
TWiV reviews findings that increased fitness of the Omicron variant is due to immune evasion, not an increase in intrinsic transmissibility, and determination of infectious viral load in patients infected with wild type, Delta and Omicron viruses reveals lack of correlation with RNA loads determined by RT-PCR, similar levels of shedding among Delta and Omicron, and greatly reduced shedding in vaccinated people. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Travel Awa...
Source: This Week in Virology - MP3 Edition - January 16, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 853: COVID-19 clinical update #97 with Dr. Daniel Griffin
In COVID-19 clinical update #97, Daniel Griffin covers immunity after infection recognized by CDC, outcomes before and after Omicron, infectious viral load in Delta vs Omicron, PCR vs rapid antigen tests, booster interval shortened to 5 months, risk factors for severe outcomes in vaccinated, cross-reactive memory T cells, vaccine effectiveness vs MIS-C, and Rivaroxiban for thromboprophylaxis. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Quarantine and isolation (CDC) Outcomes before and after Omicron (medRxiv) Infectious viral load in Delta vs Omicron infecti...
Source: This Week in Virology - MP3 Edition - January 15, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
