Inhibition of tumor migration and invasion by fenofibrate via suppressing epithelial-mesenchymal transition in breast cancers
In this study, we examined five lipid-lowering drugs: swertiamarin, gemfibrozil, clofibrate, bezafibrate, and fenofibrate in triple-negative breast cancer, which is the most migration-prone subtype. Using human and murine triple-negative breast cancer cell lines (Hs 578 t and 4 T1), we found that fenofibrate displays the highest potential in inhibiting the colony formation, wound healing, and transwell migration. We further discovered that fenofibrate reduces the activity of pro-metastatic enzymes, matrix metalloproteinases (MMP)-9 and MMP-2. In addition, epithelial markers including E-cadherin and Zonula occludens-1 are i...
Source: Toxicology and Applied Pharmacology - January 12, 2024 Category: Toxicology Authors: Yen-Chang Chen Jia-Hong Chen Cheng-Fang Tsai Chen-Teng Wu Pei-Chun Chang Wei-Lan Yeh Source Type: research
Fenofibrate alleviates NAFLD by enhancing the PPAR α/PGC-1α signaling pathway coupling mitochondrial function
CONCLUSION: Fenofibrate up-regulated PPARα/PGC-1α signaling pathway, promoted mitochondrial β-oxidation, reduced oxidative stress damage and lipid accumulation of liver. PGC-1α overexpression enhanced mitochondrial biosynthesis and ATP production, and reduced HepG2 intracellular accumulation of lipids and oxidative stress.PMID:38173037 | DOI:10.1186/s40360-023-00730-6 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - January 4, 2024 Category: Drugs & Pharmacology Authors: Xuemei Wang Jieying Wang Cao Ying Yuan Xing Xuan Su Ke Men Source Type: research
Fenofibrate alleviates NAFLD by enhancing the PPAR α/PGC-1α signaling pathway coupling mitochondrial function
CONCLUSION: Fenofibrate up-regulated PPARα/PGC-1α signaling pathway, promoted mitochondrial β-oxidation, reduced oxidative stress damage and lipid accumulation of liver. PGC-1α overexpression enhanced mitochondrial biosynthesis and ATP production, and reduced HepG2 intracellular accumulation of lipids and oxidative stress.PMID:38173037 | PMC:PMC10765888 | DOI:10.1186/s40360-023-00730-6 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - January 4, 2024 Category: Drugs & Pharmacology Authors: Xuemei Wang Jieying Wang Cao Ying Yuan Xing Xuan Su Ke Men Source Type: research
Fenofibrate alleviates NAFLD by enhancing the PPAR α/PGC-1α signaling pathway coupling mitochondrial function
To comprehend the influences of fenofibrate on hepatic lipid accumulation and mitochondrial function-related signaling pathways in mice with non-alcoholic fatty liver disease (NAFLD) secondary to high-fat diet... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - January 3, 2024 Category: Drugs & Pharmacology Authors: Xuemei Wang, Jieying Wang, Cao Ying, Yuan Xing, Xuan Su and Ke Men Tags: Research Source Type: research
Role of PPAR α in inflammatory response of C2C12 myotubes
Biochem Biophys Res Commun. 2023 Dec 20;694:149413. doi: 10.1016/j.bbrc.2023.149413. Online ahead of print.ABSTRACTRecent studies have shown a role of inflammation in muscle atrophy and sarcopenia. However, no anti-inflammatory pharmacotherapy has been established for the treatment of sarcopenia. Here, we investigate the potential role of PPARα and its ligands on inflammatory response and PGC-1α gene expression in LPS-treated C2C12 myotubes. Knockdown of PPARα, whose expression was upregulated upon differentiation, augmented IL-6 or TNFα gene expression. Conversely, PPARα overexpression or its activation by ligands su...
Source: Biochemical and Biophysical Research communications - December 23, 2023 Category: Biochemistry Authors: Yuki Shimizu Keiko Hamada Tingting Guo Chie Hasegawa Yusuke Kuga Katsushi Takeda Takashi Yagi Hiroyuki Koyama Hiroshi Takagi Daisuke Aotani Hiromi Kataoka Tomohiro Tanaka Source Type: research
Developing an in vitro lipolysis model for real-time analysis of drug concentrations during digestion of lipid-based formulations
This study explores the use of alternative lipases with the aim of selecting digestion conditions that permit in-line UV detection for the determination of real-time drug concentrations. A range of immobilised and pre-dissolved lipases were assessed for digestion of lipid-based formulations and compared to digestion with the classical source of lipase, porcine pancreatin. Palatase® 20000 L, a purified liquid lipase, displayed comparable digestion kinetics to porcine pancreatin and drug concentration determined during digestion of a fenofibrate lipid-based formulation were similar between methods. In-line UV analysis using...
Source: European Journal of Pharmaceutical Sciences - December 21, 2023 Category: Drugs & Pharmacology Authors: Lotte Ejskj ær Patrick J O'Dwyer Callum D Ryan Ren é Holm Martin Kuentz Karl J Box Brendan T Griffin Source Type: research
Developing an in vitro lipolysis model for real-time analysis of drug concentrations during digestion of lipid-based formulations
This study explores the use of alternative lipases with the aim of selecting digestion conditions that permit in-line UV detection for the determination of real-time drug concentrations. A range of immobilised and pre-dissolved lipases were assessed for digestion of lipid-based formulations and compared to digestion with the classical source of lipase, porcine pancreatin. Palatase® 20000 L, a purified liquid lipase, displayed comparable digestion kinetics to porcine pancreatin and drug concentration determined during digestion of a fenofibrate lipid-based formulation were similar between methods. In-line UV analysis using...
Source: European Journal of Pharmaceutical Sciences - December 21, 2023 Category: Drugs & Pharmacology Authors: Lotte Ejskj ær Patrick J O'Dwyer Callum D Ryan Ren é Holm Martin Kuentz Karl J Box Brendan T Griffin Source Type: research
Developing an in vitro lipolysis model for real-time analysis of drug concentrations during digestion of lipid-based formulations
This study explores the use of alternative lipases with the aim of selecting digestion conditions that permit in-line UV detection for the determination of real-time drug concentrations. A range of immobilised and pre-dissolved lipases were assessed for digestion of lipid-based formulations and compared to digestion with the classical source of lipase, porcine pancreatin. Palatase® 20000 L, a purified liquid lipase, displayed comparable digestion kinetics to porcine pancreatin and drug concentration determined during digestion of a fenofibrate lipid-based formulation were similar between methods. In-line UV analysis using...
Source: European Journal of Pharmaceutical Sciences - December 21, 2023 Category: Drugs & Pharmacology Authors: Lotte Ejskj ær Patrick J O'Dwyer Callum D Ryan Ren é Holm Martin Kuentz Karl J Box Brendan T Griffin Source Type: research
Molecules, Vol. 29, Pages 12: Design and Synthesis of Novel Indole Ethylamine Derivatives as a Lipid Metabolism Regulator Targeting PPAR & alpha;/CPT1 in AML12 Cells
Molecules, Vol. 29, Pages 12: Design and Synthesis of Novel Indole Ethylamine Derivatives as a Lipid Metabolism Regulator Targeting PPARα/CPT1 in AML12 Cells
Molecules doi: 10.3390/molecules29010012
Authors:
Yu-Chen Liu
Gang Wei
Zhi-Qiang Liao
Fang-Xin Wang
Chunxiao Zong
Jiannan Qiu
Yifei Le
Zhi-Ling Yu
Seo Young Yang
Heng-Shan Wang
Xiao-Bing Dou
Cai-Yi Wang
Peroxisome proliferator-activated receptor alpha (PPARα) and carnitine palmitoyltransferase 1 (CPT1) are important targets of lipid metabolism regulation for nonalcoholic fatty liver disease (NAFLD) therapy. In the ...
Source: Molecules - December 19, 2023 Category: Chemistry Authors: Yu-Chen Liu Gang Wei Zhi-Qiang Liao Fang-Xin Wang Chunxiao Zong Jiannan Qiu Yifei Le Zhi-Ling Yu Seo Young Yang Heng-Shan Wang Xiao-Bing Dou Cai-Yi Wang Tags: Article Source Type: research
Yacon root extract improves lipid metabolism in hyperlipidemic rats by inhibiting HMGCR expression and activating the PPAR < em > α < /em > /CYP7A1/CPT-1 pathway
CONCLUSION: Yacon root extract can reduce serum TG and TC levels in HLP rats possibly by inhibiting HMGCR expression and activating the PPARα/CYP7A1/CPT-1 signaling pathway, thereby promoting fatty acid β oxidation and bile acid metabolism.PMID:38081618 | DOI:10.12122/j.issn.1673-4254.2023.11.20 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - December 11, 2023 Category: Universities & Medical Training Authors: S Gong J Yang J Zhang X Wu S Jiang Y Zhang G Gong N Wu J Sun Z Wu Source Type: research
Yacon root extract improves lipid metabolism in hyperlipidemic rats by inhibiting HMGCR expression and activating the PPAR < em > α < /em > /CYP7A1/CPT-1 pathway
CONCLUSION: Yacon root extract can reduce serum TG and TC levels in HLP rats possibly by inhibiting HMGCR expression and activating the PPARα/CYP7A1/CPT-1 signaling pathway, thereby promoting fatty acid β oxidation and bile acid metabolism.PMID:38081618 | PMC:PMC10713474 | DOI:10.12122/j.issn.1673-4254.2023.11.20 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - December 11, 2023 Category: Universities & Medical Training Authors: S Gong J Yang J Zhang X Wu S Jiang Y Zhang G Gong N Wu J Sun Z Wu Source Type: research
Yacon root extract improves lipid metabolism in hyperlipidemic rats by inhibiting HMGCR expression and activating the PPAR < em > α < /em > /CYP7A1/CPT-1 pathway
CONCLUSION: Yacon root extract can reduce serum TG and TC levels in HLP rats possibly by inhibiting HMGCR expression and activating the PPARα/CYP7A1/CPT-1 signaling pathway, thereby promoting fatty acid β oxidation and bile acid metabolism.PMID:38081618 | PMC:PMC10713474 | DOI:10.12122/j.issn.1673-4254.2023.11.20 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - December 11, 2023 Category: Universities & Medical Training Authors: S Gong J Yang J Zhang X Wu S Jiang Y Zhang G Gong N Wu J Sun Z Wu Source Type: research
