A novel mouse model of familial combined hyperlipidemia and atherosclerosis
In this study, we constructed a novel mouse model of familial combined hyperlipidemia through inserting a human ApoC3 transgene (hApoC3-Tg) into C57BL/6 J mice and injecting a gain-of-function variant of adeno-associated virus-proprotein convertase subtilisin/kexin type 9 (AAV-PCSK9)-D377Y concurrently with high cholesterol diet (HCD) feeding for 16 weeks. In the last 10 weeks, hApoC3-Tg mice were orally treated with a combination of atorvastatin (10 mg·kg-1·d-1) and fenofibrate (100 mg·kg-1·d-1). HCD-treated hApoC3-Tg mice demonstrated elevated levels of serum TG, total cholesterol (TC) and low density lipoprotein-cho...
Source: Acta Pharmacologica Sinica - March 8, 2024 Category: Drugs & Pharmacology Authors: Mei-Jie Chen Yi-Tong Xu Lu Sun Zhi-Hua Wang Peter J Little Li Wang Xun-de Xian Jian-Ping Weng Suo-Wen Xu Source Type: research
A novel mouse model of familial combined hyperlipidemia and atherosclerosis
In this study, we constructed a novel mouse model of familial combined hyperlipidemia through inserting a human ApoC3 transgene (hApoC3-Tg) into C57BL/6 J mice and injecting a gain-of-function variant of adeno-associated virus-proprotein convertase subtilisin/kexin type 9 (AAV-PCSK9)-D377Y concurrently with high cholesterol diet (HCD) feeding for 16 weeks. In the last 10 weeks, hApoC3-Tg mice were orally treated with a combination of atorvastatin (10 mg·kg-1·d-1) and fenofibrate (100 mg·kg-1·d-1). HCD-treated hApoC3-Tg mice demonstrated elevated levels of serum TG, total cholesterol (TC) and low density lipoprotein-cho...
Source: Acta Pharmacologica Sinica - March 8, 2024 Category: Drugs & Pharmacology Authors: Mei-Jie Chen Yi-Tong Xu Lu Sun Zhi-Hua Wang Peter J Little Li Wang Xun-de Xian Jian-Ping Weng Suo-Wen Xu Source Type: research
A novel mouse model of familial combined hyperlipidemia and atherosclerosis
In this study, we constructed a novel mouse model of familial combined hyperlipidemia through inserting a human ApoC3 transgene (hApoC3-Tg) into C57BL/6 J mice and injecting a gain-of-function variant of adeno-associated virus-proprotein convertase subtilisin/kexin type 9 (AAV-PCSK9)-D377Y concurrently with high cholesterol diet (HCD) feeding for 16 weeks. In the last 10 weeks, hApoC3-Tg mice were orally treated with a combination of atorvastatin (10 mg·kg-1·d-1) and fenofibrate (100 mg·kg-1·d-1). HCD-treated hApoC3-Tg mice demonstrated elevated levels of serum TG, total cholesterol (TC) and low density lipoprotein-cho...
Source: Acta Pharmacologica Sinica - March 8, 2024 Category: Drugs & Pharmacology Authors: Mei-Jie Chen Yi-Tong Xu Lu Sun Zhi-Hua Wang Peter J Little Li Wang Xun-de Xian Jian-Ping Weng Suo-Wen Xu Source Type: research
Disturbed brain energy metabolism in a rodent model of DYT-TOR1A dystonia
Neurobiol Dis. 2024 Mar 3:106462. doi: 10.1016/j.nbd.2024.106462. Online ahead of print.ABSTRACTDYT-TOR1A (DYT1) dystonia, characterized by reduced penetrance and suspected environmental triggers, is explored using a "second hit" DYT-TOR1A rat model. We aim to investigate the biological mechanisms driving the conversion into a dystonic phenotype, focusing on the striatum's role in dystonia pathophysiology. Sciatic nerve crush injury was induced in ∆ETorA rats, lacking spontaneous motor abnormalities, and wild-type (wt) rats. Twelve weeks post-injury, unbiased RNA-sequencing was performed on the striatum to identify diffe...
Source: Neurobiology of Disease - March 5, 2024 Category: Neurology Authors: Susanne Knorr Lisa Rauschenberger Muthuraman Muthuraman Rhonda McFleder Thomas Ott Kathrin Grundmann-Hauser Takahiro Higuchi Jens Volkmann Chi Wang Ip Source Type: research
Disturbed brain energy metabolism in a rodent model of DYT-TOR1A dystonia
Neurobiol Dis. 2024 Mar 3:106462. doi: 10.1016/j.nbd.2024.106462. Online ahead of print.ABSTRACTDYT-TOR1A (DYT1) dystonia, characterized by reduced penetrance and suspected environmental triggers, is explored using a "second hit" DYT-TOR1A rat model. We aim to investigate the biological mechanisms driving the conversion into a dystonic phenotype, focusing on the striatum's role in dystonia pathophysiology. Sciatic nerve crush injury was induced in ∆ETorA rats, lacking spontaneous motor abnormalities, and wild-type (wt) rats. Twelve weeks post-injury, unbiased RNA-sequencing was performed on the striatum to identify diffe...
Source: Neurobiology of Disease - March 5, 2024 Category: Neurology Authors: Susanne Knorr Lisa Rauschenberger Muthuraman Muthuraman Rhonda McFleder Thomas Ott Kathrin Grundmann-Hauser Takahiro Higuchi Jens Volkmann Chi Wang Ip Source Type: research
Switching from Conventional Fibrates to Pemafibrate Has Beneficial Effects on the Renal Function of Diabetic Subjects with Chronic Kidney Disease
CONCLUSION: A switch to pemafibrate may be associated with an elevation in eGFR, but to a lesser extent in patients with poor renal function.PMID:38419467 | DOI:10.4093/dmj.2023.0370 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 29, 2024 Category: Endocrinology Authors: Rimi Izumihara Hiroshi Nomoto Kenichi Kito Yuki Yamauchi Kazuno Omori Yui Shibayama Shingo Yanagiya Aika Miya Hiraku Kameda Kyu Yong Cho So Nagai Ichiro Sakuma Akinobu Nakamura Tatsuya Atsumi PARM-T2D Study Group Source Type: research
Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice
This study demonstrates the reliability of metabolomics for chemical grouping and works towards best-practice.PMID:38368582 | DOI:10.1007/s00204-024-03680-y (Source: Archives of Toxicology)
Source: Archives of Toxicology - February 18, 2024 Category: Toxicology Authors: Mark R Viant E Amstalden T Athersuch M Bouhifd S Camuzeaux D M Crizer P Driemert T Ebbels D Ekman B Flick V Giri M G ómez-Romero V Haake M Herold A Kende F Lai P E G Leonards P P Lim G R Lloyd J Mosley C Namini J R Rice S Romano C Sands M J Smith T Soban Source Type: research
