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Evaluation of clinical efficacy of streptokinase by comparison with the thrombolytic agent on animal model
This study aimed to produce streptokinase from Streptococcus pyogenes EBL-48 and compare its efficacy with heparin in an animal model. We evaluated the clot-lysing effectiveness of streptokinase produced from Streptococcus pyogenes EBL-48, emphasizing its low cost and ease of production. Streptokinase was produced using pre-optimized fermentation media and purified through ion exchange and gel-filtration chromatography. In vivo analysis involved inducing clots in a trial animal model using ferric chloride, comparing streptokinase with heparin. Ultrasonography assessed the clot-lysing activity of streptokinase. Streptokinas...
Source: Braz J Biol - February 29, 2024 Category: Biology Authors: S Yousaf M Arshad F A Harraz R Masood M A Zia M Jalalah M Faisal Source Type: research

Can the combination of antiplatelet or alteplase thrombolytic therapy with argatroban benefit patients suffering from acute stroke? a systematic review, meta-analysis, and meta-regression
ConclusionThe results of this study suggest that further research into combination therapy with argatroban and antiplatelet agents may be warranted, however more rigorous RCTs are needed to definitively evaluate the effects of combination treatment. (Source: PLoS One)
Source: PLoS One - February 27, 2024 Category: Biomedical Science Authors: Haiyan Xie Source Type: research

Effectiveness of endovascular treatment for in-hospital stroke vs. community-onset stroke: a propensity score-matched analysis
ConclusionEndovascular treatment is a safe and effective treatment for eligible patients with in-hospital stroke. Our results will help physicians in making decisions when planning treatment and counseling caregivers or patients. (Source: Journal of Neurology)
Source: Journal of Neurology - February 20, 2024 Category: Neurology Source Type: research

Intraoperative vascular air embolism and intracardiac thrombosis complicating liver transplantation: a case report
ConclusionsThis report highlights the potential for simultaneous intraoperative complications during orthotopic liver transplantation, manifesting at any phase of the surgery. It underscores the critical importance of vigilant monitoring throughout orthotopic liver transplantation to promptly identify and effectively address these rare yet potentially catastrophic complications. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - February 18, 2024 Category: General Medicine Source Type: research

Acute Kidney Injury in Acute Myocardial Infarction and Its Outcome at 3 and 6 Months
According to this study, if indicated, a percutaneous coronary intervention should not be denied to patients for fear of developing AKI. This needs to be examined in larger randomized trials.PMID:38345584 | DOI:10.4103/1319-2442.395445 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Jaspreet Kaur Nidhi Bhardwaj Sreenivas Reddy Sanjay D'Cruz Source Type: research