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Understanding the influence of the microbiome on childhood infections
Expert Rev Anti Infect Ther. 2024 Apr 12:1-17. doi: 10.1080/14787210.2024.2340664. Online ahead of print.ABSTRACTINTRODUCTION: The microbiome is known to have a substantial impact on human health and disease. However, the impacts of the microbiome on immune system development, susceptibility to infectious diseases, and vaccine-elicited immune responses are emerging areas of interest.AREAS COVERED: In this review, we provide an overview of development of the microbiome during childhood. We highlight available data suggesting that the microbiome is critical to maturation of the immune system and modifies susceptibility to a ...
Source: Expert Review of Anti-Infective Therapy - April 12, 2024 Category: Infectious Diseases Authors: Sarah M Heston Jillian H Hurst Matthew S Kelly Source Type: research

< em > Mycoplasmoides genitalium < /em > Macrolide Resistance Detection is Needed in University Settings
Conclusion: Data indicate a need for molecular M. genitalium macrolide resistance determination from primary specimens in the university setting.PMID:38609142 | DOI:10.3121/cmr.2024.1871 (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - April 12, 2024 Category: General Medicine Authors: Stephen C Lavey Brittany Cassel Erik Munson Source Type: research

Walking a thin line between fixation and epitope binding – characterization of antigen retrieval methods suitable for eosinophil and HSV-2 staining in formalin-fixed female reproductive tissue
Antibody-based fluorescence analysis of female reproductive tissues in research of sexually transmitted diseases allows for an in-depth understanding of protein localization, interactions, and pathogenesis. However, in many cases, cryosectioning is not compatible with biosafety regulations; at all times, exposure of lab personnel and the public to potentially harmful pathogens from biological infectious material must be avoided; thus, formaldehyde fixation is essential. Due to formaldehyde ’s cross-linking properties, protein detection with antibodies can be impeded. To allow effective epitope binding during immunofluore...
Source: European Journal of Histochemistry - April 12, 2024 Category: Biomedical Science Authors: Lisa Marie Wadephul, Kathrin Arndts, Gnatoulma Katawa, Eva Dietlmeier, William Horsnell, Achim Hoerauf, Manuel Ritter Source Type: research

Long-term variations of urban –Rural disparities in infectious disease burden of over 8.44 million children, adolescents, and youth in China from 2013 to 2021: An observational study
The objective of our study was to evaluate the long-term urban –rural disparities in infectious diseases among children, adolescents, and youths in China, while also examining the specific diseases driving these disparities. Methods and findingsThis observational study examined data on 43 notifiable infectious diseases from 8,442,956 cases from individuals aged 4 to 24 years, with 4,487,043 cases in urban areas and 3,955,913 in rural areas. The data from 2013 to 2021 were obtained from China ’s Notifiable Infectious Disease Surveillance System. The 43 infectious diseases were categorized into 7 categories: vaccine-prev...
Source: PLoS Medicine - April 12, 2024 Category: Internal Medicine Authors: Li Chen Source Type: research