TREM1/DAP12 based novel multiple chain CAR-T cells targeting DLL3 show robust anti-tumour efficacy for small cell lung cancer
In this study, we have developed a DLL3-TREM1/DAP12 CAR-T (DLL3-DT CAR-T) therapy, demonstrating comparable anti-tumour efficacy against SCLC cells in vitro. In murine xenograft and patient-derived xenograft models, DLL3-DT CAR-T cells exhibited a more robust tumour eradication efficiency than second-generation DLL3-BBZ CAR-T cells. Furthermore, we observed elevated memory phenotypes, induced durable responses, and activation under antigen-presenting cells in DLL3-DT CAR-T cells. Collectively, these findings suggest that DLL3-DT CAR-T cells may offer a novel and potentially effective therapeutic strategy for treating DLL3-...
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Fengqi Nie Yuli Chen Yanming Hu Peng Huang Xuefei Shi Jingsheng Cai Mantang Qiu Enxiu Wang Kaihua Lu Ming Sun Source Type: research
TREM1/DAP12 based novel multiple chain CAR-T cells targeting DLL3 show robust anti-tumour efficacy for small cell lung cancer
In this study, we have developed a DLL3-TREM1/DAP12 CAR-T (DLL3-DT CAR-T) therapy, demonstrating comparable anti-tumour efficacy against SCLC cells in vitro. In murine xenograft and patient-derived xenograft models, DLL3-DT CAR-T cells exhibited a more robust tumour eradication efficiency than second-generation DLL3-BBZ CAR-T cells. Furthermore, we observed elevated memory phenotypes, induced durable responses, and activation under antigen-presenting cells in DLL3-DT CAR-T cells. Collectively, these findings suggest that DLL3-DT CAR-T cells may offer a novel and potentially effective therapeutic strategy for treating DLL3-...
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Fengqi Nie Yuli Chen Yanming Hu Peng Huang Xuefei Shi Jingsheng Cai Mantang Qiu Enxiu Wang Kaihua Lu Ming Sun Source Type: research
TREM1/DAP12 based novel multiple chain CAR-T cells targeting DLL3 show robust anti-tumour efficacy for small cell lung cancer
In this study, we have developed a DLL3-TREM1/DAP12 CAR-T (DLL3-DT CAR-T) therapy, demonstrating comparable anti-tumour efficacy against SCLC cells in vitro. In murine xenograft and patient-derived xenograft models, DLL3-DT CAR-T cells exhibited a more robust tumour eradication efficiency than second-generation DLL3-BBZ CAR-T cells. Furthermore, we observed elevated memory phenotypes, induced durable responses, and activation under antigen-presenting cells in DLL3-DT CAR-T cells. Collectively, these findings suggest that DLL3-DT CAR-T cells may offer a novel and potentially effective therapeutic strategy for treating DLL3-...
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Fengqi Nie Yuli Chen Yanming Hu Peng Huang Xuefei Shi Jingsheng Cai Mantang Qiu Enxiu Wang Kaihua Lu Ming Sun Source Type: research
TREM1/DAP12 based novel multiple chain CAR-T cells targeting DLL3 show robust anti-tumour efficacy for small cell lung cancer
In this study, we have developed a DLL3-TREM1/DAP12 CAR-T (DLL3-DT CAR-T) therapy, demonstrating comparable anti-tumour efficacy against SCLC cells in vitro. In murine xenograft and patient-derived xenograft models, DLL3-DT CAR-T cells exhibited a more robust tumour eradication efficiency than second-generation DLL3-BBZ CAR-T cells. Furthermore, we observed elevated memory phenotypes, induced durable responses, and activation under antigen-presenting cells in DLL3-DT CAR-T cells. Collectively, these findings suggest that DLL3-DT CAR-T cells may offer a novel and potentially effective therapeutic strategy for treating DLL3-...
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Fengqi Nie Yuli Chen Yanming Hu Peng Huang Xuefei Shi Jingsheng Cai Mantang Qiu Enxiu Wang Kaihua Lu Ming Sun Source Type: research
Role of CD38 in anti-tumor immunity of small cell lung cancer
ConclusionOur study provides a preliminary but important direction toward exploring CD38 as a potential biomarker of ICB response and CD38 blockade as a combination strategy for chemo-immunotherapy in SCLC. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 12, 2024 Category: Allergy & Immunology Source Type: research
GSE168709 mRNA expression data of Mes vs. Epi cells in mouse non-NE SCLC
Contributors : Hongbin Ji ; Yujuan JinSeries Type : Expression profiling by arrayOrganism : Mus musculusDistinct mRNA populatins have been detected in Epi vs. Mes cells of mouse non-NE SCLCThe aim of the study was to globally profile the differential gene expression in Mes vs. Epi cells of mouse non-NE SCLC. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 11, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Predicting overall survival and prophylactic cranial irradiation benefit in small-cell lung cancer with CT-based deep learning: A retrospective multicenter study
Lung cancer remains the leading cause of cancer-related deaths worldwide. In the United States alone in 2022, it accounted for approximately 130,180 fatalities, constituting 21% of all cancer-related mortality [1]. Small-cell lung cancer (SCLC), a subtype of lung cancer, is a highly aggressive neuroendocrine tumor with poor differentiation. It tends to metastasize early and has an unfavorable prognosis, accounting for roughly 15% of all lung cancer cases [2,3]. Currently, SCLC is categorized into limited and extensive stages according to the widely accepted staging criteria of the Veteran Affairs Lung Group, with extensive...
Source: Radiotherapy and Oncology - March 11, 2024 Category: Radiology Authors: Xiaomin Zheng, Kaicai Liu, Na Shen, Yankun Gao, Chao Zhu, Cuiping Li, Chang Rong, Shuai Li, Baoxin Qian, Jianying Li, Xingwang Wu Tags: Original Article Source Type: research
Prognostic significance of body mass index and serum albumin as the indicators of nutritional status in small cell lung cancer
CONCLUSION: Even though BMI and serum albumin showed no prognostic value in SCLC patients treated with chemotherapy, PS was found to be the most significant prognostic factor in both LD- and ED-SCLC stages.PMID:38456321 | DOI:10.1080/00325481.2024.2328512 (Source: Postgraduate Medicine)
Source: Postgraduate Medicine - March 8, 2024 Category: Internal Medicine Authors: Faruk Tas Ak ın Ozturk Kayhan Erturk Source Type: research
Molecular features of gastroenteropancreatic neuroendocrine carcinoma: A comparative analysis with lung neuroendocrine carcinoma and digestive adenocarcinomas
CONCLUSIONS: This work demonstrated striking gene distinctions in GEPNEC compared with LNEC and adenocarcinoma and their clinical utility.PMID:38455367 | PMC:PMC10915635 | DOI:10.21147/j.issn.1000-9604.2024.01.09 (Source: Cell Research)
Source: Cell Research - March 8, 2024 Category: Cytology Authors: Jianwei Zhang Hanxiao Chen Junli Zhang Sha Wang Yanfang Guan Wenguang Gu Jie Li Xiaotian Zhang Jian Li Xicheng Wang Zhihao Lu Jun Zhou Zhi Peng Yu Sun Yang Shao Lin Shen Minglei Zhuo Ming Lu Source Type: research
Prognostic significance of body mass index and serum albumin as the indicators of nutritional status in small cell lung cancer
CONCLUSION: Even though BMI and serum albumin showed no prognostic value in SCLC patients treated with chemotherapy, PS was found to be the most significant prognostic factor in both LD- and ED-SCLC stages.PMID:38456321 | DOI:10.1080/00325481.2024.2328512 (Source: Postgraduate Medicine)
Source: Postgraduate Medicine - March 8, 2024 Category: Internal Medicine Authors: Faruk Tas Ak ın Ozturk Kayhan Erturk Source Type: research
Emerging role of tumor suppressing microRNAs as therapeutics in managing non-small cell lung cancer
Pathol Res Pract. 2024 Feb 23;256:155222. doi: 10.1016/j.prp.2024.155222. Online ahead of print.ABSTRACTLung cancer (LC) is the second leading cause of death across the globe after breast cancer. There are two types of LC viz. small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC accounts for approximately 85% of all LC cases. NSCLC affects smokers and people who do not smoke and mainly arises in bronchi and peripheral lungs tissue. LC is often characterized by the alterations of key genes such as EGFR, Wnt/β-catenin signaling, ALK, MET, K-Ras and p53 and downstream signaling pathways associated with...
Source: Pathology, Research and Practice - March 7, 2024 Category: Pathology Authors: Shubham Singh Sangeeta Saxena Himani Sharma Keshav Raj Paudel Amlan Chakraborty Ronan MacLoughlin Brian G Oliver Gaurav Gupta Poonam Negi Sachin Kumar Singh Kamal Dua Source Type: research
Preparation of etoposide liposomes for enhancing antitumor efficacy on small cell lung cancer and reducing hematotoxicity of drugs
Eur J Pharm Biopharm. 2024 Mar 5:114239. doi: 10.1016/j.ejpb.2024.114239. Online ahead of print.ABSTRACTEtoposide (VP-16) is commonly used in the treatment of small cell lung cancer (SCLC) in clinical practice. However, severe adverse reactions such as bone marrow suppression toxicity limit its clinical application. Although several studies on VP16 liposomes were reported, no significant improvement in bone marrow suppression toxicity has been found, and there was a lack of validation of animal models for in vivo antitumor effects. Therefore, we attempted to develop a PEGylated liposomal formulation that effectively encaps...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 7, 2024 Category: Drugs & Pharmacology Authors: Ruixue Huang Huali Chen Damao Pi Xuemei He Chao Yu Chaoqun Yu Source Type: research
Emerging role of tumor suppressing microRNAs as therapeutics in managing non-small cell lung cancer
Pathol Res Pract. 2024 Feb 23;256:155222. doi: 10.1016/j.prp.2024.155222. Online ahead of print.ABSTRACTLung cancer (LC) is the second leading cause of death across the globe after breast cancer. There are two types of LC viz. small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC accounts for approximately 85% of all LC cases. NSCLC affects smokers and people who do not smoke and mainly arises in bronchi and peripheral lungs tissue. LC is often characterized by the alterations of key genes such as EGFR, Wnt/β-catenin signaling, ALK, MET, K-Ras and p53 and downstream signaling pathways associated with...
Source: Pathology, Research and Practice - March 7, 2024 Category: Pathology Authors: Shubham Singh Sangeeta Saxena Himani Sharma Keshav Raj Paudel Amlan Chakraborty Ronan MacLoughlin Brian G Oliver Gaurav Gupta Poonam Negi Sachin Kumar Singh Kamal Dua Source Type: research
Preparation of etoposide liposomes for enhancing antitumor efficacy on small cell lung cancer and reducing hematotoxicity of drugs
Eur J Pharm Biopharm. 2024 Mar 5:114239. doi: 10.1016/j.ejpb.2024.114239. Online ahead of print.ABSTRACTEtoposide (VP-16) is commonly used in the treatment of small cell lung cancer (SCLC) in clinical practice. However, severe adverse reactions such as bone marrow suppression toxicity limit its clinical application. Although several studies on VP16 liposomes were reported, no significant improvement in bone marrow suppression toxicity has been found, and there was a lack of validation of animal models for in vivo antitumor effects. Therefore, we attempted to develop a PEGylated liposomal formulation that effectively encaps...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 7, 2024 Category: Drugs & Pharmacology Authors: Ruixue Huang Huali Chen Damao Pi Xuemei He Chao Yu Chaoqun Yu Source Type: research
