Simvastatin-loaded 3D aerogel scaffolds promote bone regeneration
CONCLUSION: The PLCL/gelatin aerogel scaffold, when loaded with Simvastatin, demonstrates a more pronounced potential in enhancing osteoblast proliferation and osteogenic differentiation. We hypothesize that this scaffold could serve as a promising material for addressing bone defects.PMID:38363602 | DOI:10.3233/BME-230068 (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - February 16, 2024 Category: Materials Science Authors: Lai Linfeng Zhou Xiaowei Chen Xueqin Zhu Xianfeng Source Type: research
Simvastatin-loaded 3D aerogel scaffolds promote bone regeneration
CONCLUSION: The PLCL/gelatin aerogel scaffold, when loaded with Simvastatin, demonstrates a more pronounced potential in enhancing osteoblast proliferation and osteogenic differentiation. We hypothesize that this scaffold could serve as a promising material for addressing bone defects.PMID:38363602 | DOI:10.3233/BME-230068 (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - February 16, 2024 Category: Materials Science Authors: Lai Linfeng Zhou Xiaowei Chen Xueqin Zhu Xianfeng Source Type: research
Simvastatin-loaded 3D aerogel scaffolds promote bone regeneration
CONCLUSION: The PLCL/gelatin aerogel scaffold, when loaded with Simvastatin, demonstrates a more pronounced potential in enhancing osteoblast proliferation and osteogenic differentiation. We hypothesize that this scaffold could serve as a promising material for addressing bone defects.PMID:38363602 | DOI:10.3233/BME-230068 (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - February 16, 2024 Category: Materials Science Authors: Lai Linfeng Zhou Xiaowei Chen Xueqin Zhu Xianfeng Source Type: research
Simvastatin-loaded 3D aerogel scaffolds promote bone regeneration
CONCLUSION: The PLCL/gelatin aerogel scaffold, when loaded with Simvastatin, demonstrates a more pronounced potential in enhancing osteoblast proliferation and osteogenic differentiation. We hypothesize that this scaffold could serve as a promising material for addressing bone defects.PMID:38363602 | DOI:10.3233/BME-230068 (Source: Bio-Medical Materials and Engineering)
Source: Bio-Medical Materials and Engineering - February 16, 2024 Category: Materials Science Authors: Lai Linfeng Zhou Xiaowei Chen Xueqin Zhu Xianfeng Source Type: research
Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS)
Conclusions
Ferritin is a clinically useful biomarker in ARDS and is associated with worse patient outcomes. These results provide support for prospective interventional trials of immunomodulatory agents targeting IL-18 in this hyperferritinaemic subgroup of patients with ARDS. (Source: Thorax)
Source: Thorax - February 15, 2024 Category: Respiratory Medicine Authors: Mehta, P., Samanta, R. J., Wick, K., Coll, R. C., Mawhinney, T., McAleavey, P. G., Boyle, A. J., Conlon, J., Shankar-Hari, M., Rogers, A., Calfee, C. S., Matthay, M. A., Summers, C., Chambers, R. C., McAuley, D. F., O'Kane, C. M. Tags: Thorax Critical care Source Type: research
Comparative evaluation of simvastatin gel in enhancing peri-implant osteoblastic activity during the Osseo integrative phase using Bone scintigraphy: A prospective case-control double blinded study
CONCLUSION: Implants placed with 1.2% simvastatin gel showed enhanced osteoblastic activity on the fourth week of implant placement, indicating faster rate of osseointegration at an early stage.PMID:38350111 | DOI:10.11607/jomi.10741 (Source: International Journal of Oral and Maxillofacial Implants)
Source: International Journal of Oral and Maxillofacial Implants - February 13, 2024 Category: ENT & OMF Authors: K S Maheshwaran Fathima Banu R Anand Kumar V Kasim Mohamed Source Type: research
Targeting cholesterol biosynthesis for AT/RT: comprehensive expression analysis and validation in newly established AT/RT cell line
AbstractAtypical teratoid/rhabdoid (AT/RT) is a rare and highly malignant tumor of the central nervous system (CNS). It is most commonly found in children less than 5 years of age and is associated with inactivation of loss of function of SMARCB1/INI1. An experimental model for AT/RT is necessary to develop new and effective therapies. We established a patient-derived new cell line (MZ611ATRT), which showed loss of BAF-47. MZ611ATRT genetically features somatic heterozygous deletion of SMARCB1 and single nucleotide deletion of the residual allele, exon 5 ([c.541delC]), resulting in a stop codon at codon 954 by frameshift...
Source: Human Cell - February 8, 2024 Category: Cytology Source Type: research
79-Year-Old Man With Massive Hemoptysis
A 79-year-old man with medical comorbidities notable for a 20-pack-year smoking history, squamous cell carcinoma (SCC), chronic kidney disease stage III, and hypothyroidism presented with hemoptysis. Home medications included aspirin, 81 mg daily, omeprazole, 10 mg twice daily, simvastatin, 20 mg daily, and albuterol nebulizers as needed for dyspnea. He estimated the volume of blood to be about a cup (approximately 200 mL) and described it as bright red with clots and associated with chest tightness. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - February 6, 2024 Category: Internal Medicine Authors: Danielle M. Shilling, Amy N. Montgomery, Regina M. Mackey Tags: Residents ’ Clinic Source Type: research
Statins affect human iPSC-derived cardiomyocytes by interfering with mitochondrial function and intracellular acidification
AbstractStatins are effective drugs in reducing cardiovascular morbidity and mortality by inhibiting cholesterol synthesis. These effects are primarily beneficial for the patient ’s vascular system. A significant number of statin users suffer from muscle complaints probably due to mitochondrial dysfunction, a mechanism that has recently been elucidated. This has raised our interest in exploring the effects of statins on cardiac muscle cells in an era where the elderly and patients with poorer functioning hearts and less metabolic spare capacity start dominating our patient population. Here, we investigated the effects of...
Source: Basic Research in Cardiology - February 2, 2024 Category: Cardiology Source Type: research
Emerging drugs for the treatment of irritability associated with autism spectrum disorder
Expert Opin Emerg Drugs. 2024 Jan 31:1-12. doi: 10.1080/14728214.2024.2313650. Online ahead of print.ABSTRACTINTRODUCTION: Autism spectrum disorder (ASD) is an early-onset disorder with a prevalence of 1% among children and reported disability-adjusted life years of 4.31 million. Irritability is a challenging behavior associated with ASD, for which medication development has lagged. More specifically, pharmacotherapy effectiveness may be limited against high adverse effects (considering side effect profiles and patient medication sensitivity); thus, the possible benefits of pharmacological interventions must be balanced ag...
Source: Expert Opinion on Emerging Drugs - January 31, 2024 Category: Drugs & Pharmacology Authors: Ahmad Shamabadi Hanie Karimi Razman Arabzadeh Bahri Mohsen Motavaselian Shahin Akhondzadeh Source Type: research
Statin-related neurocognitive disorder: a real-world pharmacovigilance study based on the FDA adverse event reporting system
CONCLUSIONS: This study suggests a significant association between the NCDE and statins, including atorvastatin, simvastatin, and pravastatin. The intensity of the association increased with age.PMID:38275183 | DOI:10.1080/17512433.2024.2311875 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - January 26, 2024 Category: Drugs & Pharmacology Authors: Min Xiao Li Li Weiwei Zhu Fengbo Wu Bin Wu Source Type: research
Organoid-guided synergistic treatment of minimal function CFTR mutations with CFTR modulators, roflumilast and simvastatin: a personalised approach
Extract
Highly effective cystic fibrosis transmembrane conductance regulator (CFTR) protein-targeting modulator therapies (HEMTs) facilitate strong clinical improvements in a large proportion of people with cystic fibrosis (CF) [1, 2]. More specifically, the European Medicines Agency and US Food and Drug Administration (FDA) approved combination of the CFTR modulators elexacaftor/tezacaftor/ivacaftor (ETI) for people with CF with at least one F508del allele, while the FDA extended eligibility for several rare genotypes [3, 4]. However, 10–15% of those with CF carry CFTR mutations that are unresponsive to HEMTs as mon...
Source: European Respiratory Journal - January 25, 2024 Category: Respiratory Medicine Authors: Spelier, S., de Winter-de Groot, K., Keijzer-Nieuwenhuijze, N., Liem, Y., van der Ent, K., Beekman, J., Kamphuis, L. S. Tags: CF and non-CF bronchiectasis Research letters Source Type: research
Simvastatin Significantly Reduced Alcohol-Induced Cardiac Damage in Adolescent Mice
This study demonstrated that Simvastatin, an FDA approved and easily accessible drug, may be beneficial in lowering the prevalence of alcohol-induced cardiovascular diseases (especially in adolescents) which will have a huge financial implication on health systems worldwide.PMID:38261135 | PMC:PMC10838240 | DOI:10.1007/s12012-023-09821-6 (Source: Cardiovascular Toxicology)
Source: Cardiovascular Toxicology - January 23, 2024 Category: Cardiology Authors: Makgotso Nchodu Alice Efuntayo Robin du Preez Hasiena Ali Oladiran I Olateju Source Type: research
Inflammatory ARDS subphenotypes are generalisable across the age spectrum
Adult patients with acute respiratory distress syndrome (ARDS) are nowadays considered to be a heterogeneous population. Profound differences in systemic inflammation, lung morphology and physiological response have been observed. The use of unsupervised statistical techniques using multiple variables have been used to identify homogeneous subgroups.1 Such subgroups derived from multidimensional data using unbiased algorithms are also called subphenotypes. They can be used to improve trial design and, finally, patient care through prognostic and predictive enrichment.2 In the adult population, two subphenotypes based on bi...
Source: Thorax - January 18, 2024 Category: Respiratory Medicine Authors: Wösten-van Asperen, R., Bos, L. D. Tags: Thorax Editorial Source Type: research
