The anti-atherosclerotic effect of Paeonol against the lipid accumulation in macrophage-derived foam cells by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 signaling pathway
Biochem Biophys Res Commun. 2024 Mar 14;708:149788. doi: 10.1016/j.bbrc.2024.149788. Online ahead of print.ABSTRACTAtherosclerosis (AS) is the underlying cause of many severe vascular diseases and is primarily characterized by abnormal lipid metabolism. Paeonol (Pae), a bioactive compound derived from Paeonia Suffruticosa Andr., is recognized for its significant role in reducing lipid accumulation. Our research objective is to explore the link between lipid buildup in foam cells originating from macrophages and the process of ferroptosis, and explore the effect and mechanism of Pae on inhibiting AS by regulating ferroptosi...
Source: Atherosclerosis - March 22, 2024 Category: Cardiology Authors: Menglong Gao Lishun Dong Yulong Yang Jinjin Yan Yuning Liang Xiaolin Ma Min Zhou Hongfei Wu Yarong Liu Min Dai Source Type: research
The anti-atherosclerotic effect of Paeonol against the lipid accumulation in macrophage-derived foam cells by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 signaling pathway
Biochem Biophys Res Commun. 2024 Mar 14;708:149788. doi: 10.1016/j.bbrc.2024.149788. Online ahead of print.ABSTRACTAtherosclerosis (AS) is the underlying cause of many severe vascular diseases and is primarily characterized by abnormal lipid metabolism. Paeonol (Pae), a bioactive compound derived from Paeonia Suffruticosa Andr., is recognized for its significant role in reducing lipid accumulation. Our research objective is to explore the link between lipid buildup in foam cells originating from macrophages and the process of ferroptosis, and explore the effect and mechanism of Pae on inhibiting AS by regulating ferroptosi...
Source: Biochemical and Biophysical Research communications - March 22, 2024 Category: Biochemistry Authors: Menglong Gao Lishun Dong Yulong Yang Jinjin Yan Yuning Liang Xiaolin Ma Min Zhou Hongfei Wu Yarong Liu Min Dai Source Type: research
The anti-atherosclerotic effect of Paeonol against the lipid accumulation in macrophage-derived foam cells by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 signaling pathway
Biochem Biophys Res Commun. 2024 Mar 14;708:149788. doi: 10.1016/j.bbrc.2024.149788. Online ahead of print.ABSTRACTAtherosclerosis (AS) is the underlying cause of many severe vascular diseases and is primarily characterized by abnormal lipid metabolism. Paeonol (Pae), a bioactive compound derived from Paeonia Suffruticosa Andr., is recognized for its significant role in reducing lipid accumulation. Our research objective is to explore the link between lipid buildup in foam cells originating from macrophages and the process of ferroptosis, and explore the effect and mechanism of Pae on inhibiting AS by regulating ferroptosi...
Source: Atherosclerosis - March 22, 2024 Category: Cardiology Authors: Menglong Gao Lishun Dong Yulong Yang Jinjin Yan Yuning Liang Xiaolin Ma Min Zhou Hongfei Wu Yarong Liu Min Dai Source Type: research
Dantrolene and coenzyme Q10 as a suggested combination therapy to statin-induced myopathy in high fat diet rats: A possible interference with ROS/ TGF- β / Smad4 signaling pathway
Toxicol Appl Pharmacol. 2024 Mar 18:116900. doi: 10.1016/j.taap.2024.116900. Online ahead of print.ABSTRACTOne of the major hitches for statins' utilization is the development of myotoxicity. Versatile studies reported that the underlining molecular mechanisms including coenzyme Q10 (CoQ10)/ubiquinone depletion, as well as the disturbance in the cytoplasmic Ca2+ homeostasis. Therefore, we investigated the consequences of supplementing CoQ10 and dantrolene, a cytoplasmic Ca2+ reducing agent, in combination with simvastatin. This adjuvant therapy normalized the simvastatin-mediated elevation in serum ALT, AST, CK-MM, as well...
Source: Toxicology and Applied Pharmacology - March 20, 2024 Category: Toxicology Authors: Sherin Zakaria Ahmed M Elshazly Reem Alaa Samer Elsebaey Source Type: research
Fabrication and characterization of a multi-functional GBR membrane of gelatin-chitosan for osteogenesis and angiogenesis
In conclusion, the multifunctional effects of Sim@PLGA/Gel-CS on the barrier and bone microenvironment were achieved via its dual-layer structure and simvastatin coating. Sim@PLGA/Gel-CS has potential applications in bone tissue regeneration.PMID:38508565 | DOI:10.1016/j.ijbiomac.2024.130978 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - March 20, 2024 Category: Biochemistry Authors: Xiaofei Hu Yuzhu He Yunmeng Tong Na Sun Guowu Ma Huiying Liu Ni Kou Source Type: research
Fabrication and characterization of a multi-functional GBR membrane of gelatin-chitosan for osteogenesis and angiogenesis
In conclusion, the multifunctional effects of Sim@PLGA/Gel-CS on the barrier and bone microenvironment were achieved via its dual-layer structure and simvastatin coating. Sim@PLGA/Gel-CS has potential applications in bone tissue regeneration.PMID:38508565 | DOI:10.1016/j.ijbiomac.2024.130978 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - March 20, 2024 Category: Biochemistry Authors: Xiaofei Hu Yuzhu He Yunmeng Tong Na Sun Guowu Ma Huiying Liu Ni Kou Source Type: research
Dantrolene and coenzyme Q10 as a suggested combination therapy to statin-induced myopathy in high fat diet rats: A possible interference with ROS/ TGF- β / Smad4 signaling pathway
Toxicol Appl Pharmacol. 2024 Mar 18:116900. doi: 10.1016/j.taap.2024.116900. Online ahead of print.ABSTRACTOne of the major hitches for statins' utilization is the development of myotoxicity. Versatile studies reported that the underlining molecular mechanisms including coenzyme Q10 (CoQ10)/ubiquinone depletion, as well as the disturbance in the cytoplasmic Ca2+ homeostasis. Therefore, we investigated the consequences of supplementing CoQ10 and dantrolene, a cytoplasmic Ca2+ reducing agent, in combination with simvastatin. This adjuvant therapy normalized the simvastatin-mediated elevation in serum ALT, AST, CK-MM, as well...
Source: Toxicology and Applied Pharmacology - March 20, 2024 Category: Toxicology Authors: Sherin Zakaria Ahmed M Elshazly Reem Alaa Samer Elsebaey Source Type: research
Platelet rich fibrin and simvastatin-loaded pectin-based 3D printed-electrospun bilayer scaffold for skin tissue regeneration
In this study, a bilayer scaffold (BS) with a top layer (TL) comprising 3D printed pectin/polyacrylic acid/platelet rich fibrin hydrogel (Pec/PAA/PRF) and a bottom nanofibrous layer (NL) containing Pec/PAA/simvastatin (SIM) was produced. The biodegradable and biocompatible polymers Pec and PAA were cross-linked to form hydrogels via Ca2+ activation through galacturonate linkage and chelation, respectively. PRF as an autologous growth factor (GF) source and SIM together augmented angiogenesis and neovascularization. Because of 3D printing, the BS possessed a uniform distribution of PRF in TL and an average fiber diameter of...
Source: International Journal of Biological Macromolecules - March 18, 2024 Category: Biochemistry Authors: Mohamadreza Tavakoli Mastafa H Al-Musawi Alma Kalali Afrooz Shekarchizadeh Yeganeh Kaviani Agrin Mansouri Sepideh Nasiri-Harchegani Anousheh Zargar Kharazi Fariborz Sharifianjazi Mamoona Sattar Jaleh Varshosaz Morteza Mehrjoo Aliakbar Najafinezhad Marjan Source Type: research
