Lipid-Lowering Meroterpenoids Penihemeroterpenoids A-F from < em > Penicillium herquei < /em > GZU-31-6 via Targeting the AMPK/ACC/SREBP-1c Signaling Pathway
Org Lett. 2024 Apr 17. doi: 10.1021/acs.orglett.4c00946. Online ahead of print.ABSTRACTPenihemeroterpenoids A-C, the first meroterpenoids with an unprecedented 6/5/6/5/5/6/5 heptacyclic ring system, together with precursors penihemeroterpenoids D-F, were co-isolated from the fungus Penicillium herquei GZU-31-6. Among them, penihemeroterpenoids C-F exhibited lipid-lowering effects comparable to those of the positive control simvastatin by the activation of the AMPK/ACC/SREBP-1c signaling pathway, downregulated the mRNA levels of lipid synthesis genes FAS and PNPLA3, and increased the level of mRNA expression of the lipid ex...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Huimei Deng Jingxin He Binglin Chang Qingcui Li Yena Liu Zhongxiang Zhao Zhongqiu Liu Hui Cui Source Type: research
Solid self-emulsifying casein carrier for the improvement on the oral bioavailability of simvastatin
Int J Biol Macromol. 2024 Apr 13:131516. doi: 10.1016/j.ijbiomac.2024.131516. Online ahead of print.ABSTRACTSimvastatin (SV) is a statin drug that can effectively control cholesterol and prevent cardiovascular diseases. However, SV is water-insoluble, and poor oral bioavailability (<5 %). Solid self-emulsifying carrier system is more stable than liquid emulsions, facilitating to improve the solubility and bioavailability of poorly soluble drugs. In the present study, a solid self-emulsifying carrier stabilized by casein (Cas-SSE) was successfully used to load SV to improve its solubility in water, by formulation selecti...
Source: International Journal of Biological Macromolecules - April 15, 2024 Category: Biochemistry Authors: Han Li Haixia Sun Yanbing Zhao Shaobin Wang Yongsheng Zhao Source Type: research
Solid self-emulsifying casein carrier for the improvement on the oral bioavailability of simvastatin
Int J Biol Macromol. 2024 Apr 13:131516. doi: 10.1016/j.ijbiomac.2024.131516. Online ahead of print.ABSTRACTSimvastatin (SV) is a statin drug that can effectively control cholesterol and prevent cardiovascular diseases. However, SV is water-insoluble, and poor oral bioavailability (<5 %). Solid self-emulsifying carrier system is more stable than liquid emulsions, facilitating to improve the solubility and bioavailability of poorly soluble drugs. In the present study, a solid self-emulsifying carrier stabilized by casein (Cas-SSE) was successfully used to load SV to improve its solubility in water, by formulation selecti...
Source: International Journal of Biological Macromolecules - April 15, 2024 Category: Biochemistry Authors: Han Li Haixia Sun Yanbing Zhao Shaobin Wang Yongsheng Zhao Source Type: research
The maximum dose of atorvastatin and simvastatin as well as rosuvastatin should be restricted in East Asians
Hong Kong Med J. 2024 Apr 12. doi: 10.12809/hkmj2311348. Online ahead of print.NO ABSTRACTPMID:38605565 | DOI:10.12809/hkmj2311348 (Source: Hong Kong Med J)
Source: Hong Kong Med J - April 12, 2024 Category: General Medicine Authors: B Tomlinson E Chow Source Type: research
The maximum dose of atorvastatin and simvastatin as well as rosuvastatin should be restricted in East Asians
Hong Kong Med J. 2024 Apr 12. doi: 10.12809/hkmj2311348. Online ahead of print.NO ABSTRACTPMID:38605565 | DOI:10.12809/hkmj2311348 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - April 12, 2024 Category: General Medicine Authors: B Tomlinson E Chow Source Type: research
The maximum dose of atorvastatin and simvastatin as well as rosuvastatin should be restricted in East Asians
Hong Kong Med J. 2024 Apr 12. doi: 10.12809/hkmj2311348. Online ahead of print.NO ABSTRACTPMID:38605565 | DOI:10.12809/hkmj2311348 (Source: Hong Kong Med J)
Source: Hong Kong Med J - April 12, 2024 Category: General Medicine Authors: B Tomlinson E Chow Source Type: research
The maximum dose of atorvastatin and simvastatin as well as rosuvastatin should be restricted in East Asians
Hong Kong Med J. 2024 Apr 12. doi: 10.12809/hkmj2311348. Online ahead of print.NO ABSTRACTPMID:38605565 | DOI:10.12809/hkmj2311348 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - April 12, 2024 Category: General Medicine Authors: B Tomlinson E Chow Source Type: research
The maximum dose of atorvastatin and simvastatin as well as rosuvastatin should be restricted in East Asians
Hong Kong Med J. 2024 Apr 12. doi: 10.12809/hkmj2311348. Online ahead of print.NO ABSTRACTPMID:38605565 | DOI:10.12809/hkmj2311348 (Source: Hong Kong Med J)
Source: Hong Kong Med J - April 12, 2024 Category: General Medicine Authors: B Tomlinson E Chow Source Type: research
The maximum dose of atorvastatin and simvastatin as well as rosuvastatin should be restricted in East Asians
Hong Kong Med J. 2024 Apr 12. doi: 10.12809/hkmj2311348. Online ahead of print.NO ABSTRACTPMID:38605565 | DOI:10.12809/hkmj2311348 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - April 12, 2024 Category: General Medicine Authors: B Tomlinson E Chow Source Type: research
Simvastatin activates the spindle assembly checkpoint and causes abnormal cell division by modifying small GTPases
In this study, we determined its effect on cell division. Cell cycle synchronization experiments revealed a delay in mitotic progression in simvastatin-treated cells at concentrations lower than the IC50. Time-lapse imaging analysis indicated that the duration of mitosis, especially from mitotic entry to anaphase onset, was prolonged. In addition, simvastatin increased the number of cells exhibiting misoriented anaphase/telophase and bleb formation. Inhibition of the spindle assembly checkpoint (SAC) kinase Mps1 canceled the mitotic delay. Additionally, the number of cells exhibiting kinetochore localization of BubR1, an e...
Source: Cellular Signalling - April 11, 2024 Category: Cytology Authors: Junna Tanaka Hiroki Kuwajima Ryuzaburo Yuki Yuji Nakayama Source Type: research
Simvastatin activates the spindle assembly checkpoint and causes abnormal cell division by modifying small GTPases
In this study, we determined its effect on cell division. Cell cycle synchronization experiments revealed a delay in mitotic progression in simvastatin-treated cells at concentrations lower than the IC50. Time-lapse imaging analysis indicated that the duration of mitosis, especially from mitotic entry to anaphase onset, was prolonged. In addition, simvastatin increased the number of cells exhibiting misoriented anaphase/telophase and bleb formation. Inhibition of the spindle assembly checkpoint (SAC) kinase Mps1 canceled the mitotic delay. Additionally, the number of cells exhibiting kinetochore localization of BubR1, an e...
Source: Cellular Signalling - April 11, 2024 Category: Cytology Authors: Junna Tanaka Hiroki Kuwajima Ryuzaburo Yuki Yuji Nakayama Source Type: research
Simvastatin activates the spindle assembly checkpoint and causes abnormal cell division by modifying small GTPases
In this study, we determined its effect on cell division. Cell cycle synchronization experiments revealed a delay in mitotic progression in simvastatin-treated cells at concentrations lower than the IC50. Time-lapse imaging analysis indicated that the duration of mitosis, especially from mitotic entry to anaphase onset, was prolonged. In addition, simvastatin increased the number of cells exhibiting misoriented anaphase/telophase and bleb formation. Inhibition of the spindle assembly checkpoint (SAC) kinase Mps1 canceled the mitotic delay. Additionally, the number of cells exhibiting kinetochore localization of BubR1, an e...
Source: Cellular Signalling - April 11, 2024 Category: Cytology Authors: Junna Tanaka Hiroki Kuwajima Ryuzaburo Yuki Yuji Nakayama Source Type: research
Simvastatin activates the spindle assembly checkpoint and causes abnormal cell division by modifying small GTPases
In this study, we determined its effect on cell division. Cell cycle synchronization experiments revealed a delay in mitotic progression in simvastatin-treated cells at concentrations lower than the IC50. Time-lapse imaging analysis indicated that the duration of mitosis, especially from mitotic entry to anaphase onset, was prolonged. In addition, simvastatin increased the number of cells exhibiting misoriented anaphase/telophase and bleb formation. Inhibition of the spindle assembly checkpoint (SAC) kinase Mps1 canceled the mitotic delay. Additionally, the number of cells exhibiting kinetochore localization of BubR1, an e...
Source: Cellular Signalling - April 11, 2024 Category: Cytology Authors: Junna Tanaka Hiroki Kuwajima Ryuzaburo Yuki Yuji Nakayama Source Type: research
Overcoming statin resistance in prostate cancer cells by targeting the 3-hydroxy-3-methylglutaryl-CoA-reductase
Biochem Biophys Res Commun. 2024 Mar 28;710:149841. doi: 10.1016/j.bbrc.2024.149841. Online ahead of print.ABSTRACTProstate cancer is the most prevalent malignancy in men. While diagnostic and therapeutic interventions have substantially improved in recent years, disease relapse, treatment resistance, and metastasis remain significant contributors to prostate cancer-related mortality. Therefore, novel therapeutic approaches are needed. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway which plays an essential role in cholesterol homeostasis. N...
Source: Biochemical and Biophysical Research communications - April 8, 2024 Category: Biochemistry Authors: Andy G öbel Sophie P ählig Anja Motz Dorit Breining Sofia Traikov Lorenz C Hofbauer Tilman D Rachner Source Type: research
Overcoming statin resistance in prostate cancer cells by targeting the 3-hydroxy-3-methylglutaryl-CoA-reductase
Biochem Biophys Res Commun. 2024 Mar 28;710:149841. doi: 10.1016/j.bbrc.2024.149841. Online ahead of print.ABSTRACTProstate cancer is the most prevalent malignancy in men. While diagnostic and therapeutic interventions have substantially improved in recent years, disease relapse, treatment resistance, and metastasis remain significant contributors to prostate cancer-related mortality. Therefore, novel therapeutic approaches are needed. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway which plays an essential role in cholesterol homeostasis. N...
Source: Cell Research - April 8, 2024 Category: Cytology Authors: Andy G öbel Sophie P ählig Anja Motz Dorit Breining Sofia Traikov Lorenz C Hofbauer Tilman D Rachner Source Type: research
