Sodium glucose cotransporter 2 inhibitors with cardiac arrhythmias in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized placebo-controlled trials
ConclusionSGLT2 inhibitors were associated with a reduced risk of atrial arrhythmias in patients with T2DM. Our results support the use of SGLT2 inhibitors in T2DM with high cardiovascular risk populations. We also recommend the long-term use of SGLT2 inhibitors to achieve further benefits.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 14, 2024 Category: Cardiology Source Type: research
Sodium –glucose cotransporter-2 inhibitors in heart failure patients across the range of body mass index: a systematic review and meta-analysis of randomized controlled trials
AbstractSodium –glucose cotransporter-2 (SGLT2) inhibitors improve outcomes in patients with heart failure, with or without diabetes. We sought to assess whether there is an interaction of these effects with body mass index (BMI). A systematic review of the MEDLINE and Scopus databases (last search: November 15t h, 2022) was performed according to the PRISMA statement. Studies eligible for this review were randomized control trials (RCTs) with patients with chronic heart failure with either preserved or reduced ejection fraction randomly assigned to SGLT2 inhibitors or placebo. Data were extracted independe ntly by two r...
Source: Internal and Emergency Medicine - February 14, 2024 Category: Emergency Medicine Source Type: research
Sodium glucose cotransporter 2 inhibitors with cardiac arrhythmias in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized placebo-controlled trials
ConclusionSGLT2 inhibitors were associated with a reduced risk of atrial arrhythmias in patients with T2DM. Our results support the use of SGLT2 inhibitors in T2DM with high cardiovascular risk populations. We also recommend the long-term use of SGLT2 inhibitors to achieve further benefits.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 14, 2024 Category: Cardiology Source Type: research
Sodium –glucose cotransporter-2 inhibitors in heart failure patients across the range of body mass index: a systematic review and meta-analysis of randomized controlled trials
AbstractSodium –glucose cotransporter-2 (SGLT2) inhibitors improve outcomes in patients with heart failure, with or without diabetes. We sought to assess whether there is an interaction of these effects with body mass index (BMI). A systematic review of the MEDLINE and Scopus databases (last search: November 15t h, 2022) was performed according to the PRISMA statement. Studies eligible for this review were randomized control trials (RCTs) with patients with chronic heart failure with either preserved or reduced ejection fraction randomly assigned to SGLT2 inhibitors or placebo. Data were extracted independe ntly by two r...
Source: Internal and Emergency Medicine - February 14, 2024 Category: Emergency Medicine Source Type: research
The highlights of dialysis in 2023
Nephrol Ther. 2024 Feb 12;20(S1):1-11. doi: 10.1684/ndt.2024.66. Online ahead of print.ABSTRACTThere has been a wealth of new developments in dialysis this year with the publication of several trials relating to dialysis technique, physical activity and the use of new dialysis treatments. Quality of life should be assessed and managed in all dialysis patients. Lowering the temperature of the dialysis bath in the MyTemp trial does not appear to have an effect on mortality and cardiovascular events. High volume convective hemodiafiltration currently represents the reference technique in hemodialysis; the Convince study confi...
Source: Nephrologie and Therapeutique - February 12, 2024 Category: Urology & Nephrology Authors: Stanislas Bataille Nodimar C éline Source Type: research
Nonlinear association between proteinuria levels and the risk of cardiovascular disease events and all-cause mortality among chronic kidney disease patients
CONCLUSION: Among non-dialyzed patients with stage G2-G5 CKD, a nonlinear association between UPCR and the primary outcome was observed. A higher UPCR (when UPCR < 3.93 g/gCr) was an independent predictor of the primary outcome. Importantly, our study predates SGLT2 inhibitor use, showcasing outcomes achievable without these medications. Future research considerations will involve factors like SGLT-2 inhibitor utilization.PMID:38345084 | PMC:PMC10863521 | DOI:10.1080/0886022X.2024.2310727 (Source: Renal Failure)
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Haiying Song Yuheng Liao Haofei Hu Qijun Wan Source Type: research
The highlights of dialysis in 2023
Nephrol Ther. 2024 Feb 12;20(S1):1-11. doi: 10.1684/ndt.2024.66. Online ahead of print.ABSTRACTThere has been a wealth of new developments in dialysis this year with the publication of several trials relating to dialysis technique, physical activity and the use of new dialysis treatments. Quality of life should be assessed and managed in all dialysis patients. Lowering the temperature of the dialysis bath in the MyTemp trial does not appear to have an effect on mortality and cardiovascular events. High volume convective hemodiafiltration currently represents the reference technique in hemodialysis; the Convince study confi...
Source: Nephrologie and Therapeutique - February 12, 2024 Category: Urology & Nephrology Authors: Stanislas Bataille Nodimar C éline Source Type: research
The highlights of dialysis in 2023
Nephrol Ther. 2024 Feb 12;20(S1):1-11. doi: 10.1684/ndt.2024.66. Online ahead of print.ABSTRACTThere has been a wealth of new developments in dialysis this year with the publication of several trials relating to dialysis technique, physical activity and the use of new dialysis treatments. Quality of life should be assessed and managed in all dialysis patients. Lowering the temperature of the dialysis bath in the MyTemp trial does not appear to have an effect on mortality and cardiovascular events. High volume convective hemodiafiltration currently represents the reference technique in hemodialysis; the Convince study confi...
Source: Nephrologie and Therapeutique - February 12, 2024 Category: Urology & Nephrology Authors: Stanislas Bataille Nodimar C éline Source Type: research
The highlights of dialysis in 2023
Nephrol Ther. 2024 Feb 12;20(S1):1-11. doi: 10.1684/ndt.2024.66. Online ahead of print.ABSTRACTThere has been a wealth of new developments in dialysis this year with the publication of several trials relating to dialysis technique, physical activity and the use of new dialysis treatments. Quality of life should be assessed and managed in all dialysis patients. Lowering the temperature of the dialysis bath in the MyTemp trial does not appear to have an effect on mortality and cardiovascular events. High volume convective hemodiafiltration currently represents the reference technique in hemodialysis; the Convince study confi...
Source: Nephrologie and Therapeutique - February 12, 2024 Category: Urology & Nephrology Authors: Stanislas Bataille Nodimar C éline Source Type: research
The highlights of dialysis in 2023
Nephrol Ther. 2024 Feb 12;20(S1):1-11. doi: 10.1684/ndt.2024.66. Online ahead of print.ABSTRACTThere has been a wealth of new developments in dialysis this year with the publication of several trials relating to dialysis technique, physical activity and the use of new dialysis treatments. Quality of life should be assessed and managed in all dialysis patients. Lowering the temperature of the dialysis bath in the MyTemp trial does not appear to have an effect on mortality and cardiovascular events. High volume convective hemodiafiltration currently represents the reference technique in hemodialysis; the Convince study confi...
Source: Nephrologie and Therapeutique - February 12, 2024 Category: Urology & Nephrology Authors: Stanislas Bataille Nodimar C éline Source Type: research
Cardiovascular and mortality outcomes with GLP-1 receptor agonists vs other glucose-lowering drugs in individuals with NAFLD and type 2 diabetes: a large population-based matched cohort study
Conclusions/interpretationIn individuals with NAFLD and type 2 diabetes, GLP-1RAs are associated with lower incidences of adverse CVEs and all-cause mortality compared with metformin or other second- and third-line glucose-lowering medications. However, there was no significant difference in adverse CVEs or all-cause mortality when compared with those taking SGLT2 inhibitors.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 11, 2024 Category: Endocrinology Source Type: research
Diabetes mellitus, glycemic traits, SGLT2 inhibition, and risk of pulmonary arterial hypertension: A Mendelian randomization study
This study aimed to investigate the causal role of diabetes mellitus (DM), glycemic traits, and sodium-glucose cotransporter 2 (SGLT2) inhibition in pulmonary arterial hypertension (PAH). Utilizing a two-sample two-step Mendelian randomization (MR) approach, we determined the causal influence of DM and glycemic traits (including insulin resistance, glycated hemoglobin, and fasting insulin and glucose) on the risk of PAH. Moreover, we examined the causal effects of SGLT2 inhibition on the risk of PAH. Genetic proxies for SGLT2 inhibition were identified as variants in the SLC5A2 gene that were associated with both levels of...
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Jiang-Shan Tan Yanmin Yang Jingyang Wang Yimeng Wang Tingting Lv Yuyuan Shu Wei Xu Lingtao Chong Source Type: research
Association of sodium-glucose cotransporter 2 inhibitors with the incidence of corneal diseases in type 2 diabetes mellitus
In conclusion, the usage of SGLT2 inhibitors correlates to lower incidence of superficial keratopathy and infectious keratitis in T2DM individuals, which is more significant in patients with persistent SGLT2 inhibitors application.PMID:38322591 | PMC:PMC10845264 | DOI:10.7150/ijms.91571 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - February 7, 2024 Category: Biomedical Science Authors: Tsan-Yu Tsai Po-Jen Yang Shih-Chun Chao Chia-Yi Lee Jing-Yang Huang Shun-Fa Yang Hung-Yu Lin Source Type: research
Diabetes mellitus, glycemic traits, SGLT2 inhibition, and risk of pulmonary arterial hypertension: A Mendelian randomization study
This study aimed to investigate the causal role of diabetes mellitus (DM), glycemic traits, and sodium-glucose cotransporter 2 (SGLT2) inhibition in pulmonary arterial hypertension (PAH). Utilizing a two-sample two-step Mendelian randomization (MR) approach, we determined the causal influence of DM and glycemic traits (including insulin resistance, glycated hemoglobin, and fasting insulin and glucose) on the risk of PAH. Moreover, we examined the causal effects of SGLT2 inhibition on the risk of PAH. Genetic proxies for SGLT2 inhibition were identified as variants in the SLC5A2 gene that were associated with both levels of...
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Jiang-Shan Tan Yanmin Yang Jingyang Wang Yimeng Wang Tingting Lv Yuyuan Shu Wei Xu Lingtao Chong Source Type: research
Association of sodium-glucose cotransporter 2 inhibitors with the incidence of corneal diseases in type 2 diabetes mellitus
In conclusion, the usage of SGLT2 inhibitors correlates to lower incidence of superficial keratopathy and infectious keratitis in T2DM individuals, which is more significant in patients with persistent SGLT2 inhibitors application.PMID:38322591 | PMC:PMC10845264 | DOI:10.7150/ijms.91571 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - February 7, 2024 Category: Biomedical Science Authors: Tsan-Yu Tsai Po-Jen Yang Shih-Chun Chao Chia-Yi Lee Jing-Yang Huang Shun-Fa Yang Hung-Yu Lin Source Type: research
