Diabetes mellitus, glycemic traits, SGLT2 inhibition, and risk of pulmonary arterial hypertension: A Mendelian randomization study
This study aimed to investigate the causal role of diabetes mellitus (DM), glycemic traits, and sodium-glucose cotransporter 2 (SGLT2) inhibition in pulmonary arterial hypertension (PAH). Utilizing a two-sample two-step Mendelian randomization (MR) approach, we determined the causal influence of DM and glycemic traits (including insulin resistance, glycated hemoglobin, and fasting insulin and glucose) on the risk of PAH. Moreover, we examined the causal effects of SGLT2 inhibition on the risk of PAH. Genetic proxies for SGLT2 inhibition were identified as variants in the SLC5A2 gene that were associated with both levels of...
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Jiang-Shan Tan Yanmin Yang Jingyang Wang Yimeng Wang Tingting Lv Yuyuan Shu Wei Xu Lingtao Chong Source Type: research
Association of sodium-glucose cotransporter 2 inhibitors with the incidence of corneal diseases in type 2 diabetes mellitus
In conclusion, the usage of SGLT2 inhibitors correlates to lower incidence of superficial keratopathy and infectious keratitis in T2DM individuals, which is more significant in patients with persistent SGLT2 inhibitors application.PMID:38322591 | PMC:PMC10845264 | DOI:10.7150/ijms.91571 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - February 7, 2024 Category: Biomedical Science Authors: Tsan-Yu Tsai Po-Jen Yang Shih-Chun Chao Chia-Yi Lee Jing-Yang Huang Shun-Fa Yang Hung-Yu Lin Source Type: research
Diabetes mellitus, glycemic traits, SGLT2 inhibition, and risk of pulmonary arterial hypertension: A Mendelian randomization study
This study aimed to investigate the causal role of diabetes mellitus (DM), glycemic traits, and sodium-glucose cotransporter 2 (SGLT2) inhibition in pulmonary arterial hypertension (PAH). Utilizing a two-sample two-step Mendelian randomization (MR) approach, we determined the causal influence of DM and glycemic traits (including insulin resistance, glycated hemoglobin, and fasting insulin and glucose) on the risk of PAH. Moreover, we examined the causal effects of SGLT2 inhibition on the risk of PAH. Genetic proxies for SGLT2 inhibition were identified as variants in the SLC5A2 gene that were associated with both levels of...
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Jiang-Shan Tan Yanmin Yang Jingyang Wang Yimeng Wang Tingting Lv Yuyuan Shu Wei Xu Lingtao Chong Source Type: research
Association of sodium-glucose cotransporter 2 inhibitors with the incidence of corneal diseases in type 2 diabetes mellitus
In conclusion, the usage of SGLT2 inhibitors correlates to lower incidence of superficial keratopathy and infectious keratitis in T2DM individuals, which is more significant in patients with persistent SGLT2 inhibitors application.PMID:38322591 | PMC:PMC10845264 | DOI:10.7150/ijms.91571 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - February 7, 2024 Category: Biomedical Science Authors: Tsan-Yu Tsai Po-Jen Yang Shih-Chun Chao Chia-Yi Lee Jing-Yang Huang Shun-Fa Yang Hung-Yu Lin Source Type: research
