China ’s COVID vaccines have been crucial — now immunity is waning
More that 3 billions doses of China's CoronaVac and Sinopharm vaccines have been administered across the globe, playing an especially important role in Latin America and South East Asia, as well as China. These vaccines use inactivated virus particles to expose the immune system to Sars-CoV-2, but they do not appear to generate the same levels of neutralising antibodies as other vaccine platforms such as those based on mRNA. Now studies are suggesting that this protection may be waning more quickly than with other vaccines, which has sparked a conundrum - in many countries the only vaccines available are CoronaVac or Sinop...
Source: Nature Podcast - October 29, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
China ’s COVID vaccines have been crucial — now immunity is waning
More that 3 billions doses of China's CoronaVac and Sinopharm vaccines have been administered across the globe, playing an especially important role in Latin America and South East Asia, as well as China. These vaccines use inactivated virus particles to expose the immune system to Sars-CoV-2, but they do not appear to generate the same levels of neutralising antibodies as other vaccine platforms such as those based on mRNA. Now studies are suggesting that this protection may be waning more quickly than with other vaccines, which has sparked a conundrum - in many countries the only vaccines available are CoronaVac or Sinop...
Source: Nature Podcast - October 29, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
TWiV 821: Public clonotype #1
A TWiV trio reveal the isolation of novel paramyxoviruses from rodents and bats in Arizona, and isolation of naive B cells from seronegative donors that produce germline encoded antibodies which engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses from bats. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bat and rodent paramyxoviruses from Arizona (J Viral) Naive B cells engage SARS-CoV-2 RBD (Science Immunol) Vincent interviews Philip Sharp (ASM) Letters rea...
Source: This Week in Virology - MP3 Edition - October 24, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 819: How to stall a copy machine
TWiV explains how remdesivir inhibits the SARS-CoV-2 RNA polymerase: the drug is incorporated into the growing RNA chain and causes synthesis to stall when the drug clashes with an amino acid in the active site. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode How remdesivir stalls the SARS-CoV-2 polymerase (Nat Comm) Movie of polymerase stalling (Nat Comm) Second mechanism of remdesivir inhibition (J Biol Chem) Watson Crick molecular model (Science Museum Group) Letters read on TWiV 819 Timest...
Source: This Week in Virology - MP3 Edition - October 21, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 818: Thor's hammer
The TWiVers review phase 3 efficacy and safety results for the Novavax COVID-19 vaccine, effects on the neonatal immune system caused by maternal infection with SARS-CoV-2, and NHC, the metabolite of molnupiravir, causes mutations in cellular DNA. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Efficacy and safety of Novavax vaccine (medRxiv) A floret of spikes with Matt Frieman (TWiV 729) Maternal SARS-CoV-2 infection affects neonatal immunity (Nat Immunol) NHC is mut...
Source: This Week in Virology - MP3 Edition - October 17, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 816: Long COVID and ME/CFS with David Tuller
David Tuller returns to TWiV to revisit his work to expose the methodological and ethical problems with the PACE trial, and the post-acute sequelae to SARS-CoV-2 infection, also known as long COVID. Host: Vincent Racaniello Guest: David Tuller Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Call me David Tuller (TWiV Special) David writes at virology blog Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - October 15, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Coronapod: new data affirms the benefits of air filters and masks
New data suggests that inexpensive, high-efficiency particulate air (HEPA) filters can effectively scrub SARS-CoV-2 particles from the air in hospital COVID wards. The result validates previous studies carried out in controlled conditions. Currently, HEPA filters are not routinely used in hospital settings, but researchers suggest they could could help mitigate the risk of tramission of airborne viruses.In addition a new study has demonstrated the effectiveness of mask wearing, with surgical masks proving more effective than those made of cloth. The trial, which involved 350,000 participants in Bangladesh, is the latest in...
Source: Nature Podcast - October 10, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
Coronapod: new data affirms the benefits of air filters and masks
New data suggests that inexpensive, high-efficiency particulate air (HEPA) filters can effectively scrub SARS-CoV-2 particles from the air in hospital COVID wards. The result validates previous studies carried out in controlled conditions. Currently, HEPA filters are not routinely used in hospital settings, but researchers suggest they could could help mitigate the risk of tramission of airborne viruses.In addition a new study has demonstrated the effectiveness of mask wearing, with surgical masks proving more effective than those made of cloth. The trial, which involved 350,000 participants in Bangladesh, is the latest in...
Source: Nature Podcast - October 10, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
TWiV 815: MIS-C with Moshe Arditi and Ivet Bahar
Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Kathy Spindler Guests: Moshe Arditi and Ivet Behar Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MIS-C in US children (NEJM) Superantigen in spike and T cell skewing in MIS-C (PNAS) MIS-C mimics toxic shock syndrome (J Allergy Clin Immunol) Antibody agains...
Source: This Week in Virology - MP3 Edition - October 10, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 813: COVID-19 at the European Society for Clinical Virology
From the 2021 online meeting of the European Society for Clinical Virology, Vincent speaks with meeting speakers on COVID-19 vaccines, immunity, how countries responded to the pandemic, and how to prepare for the next one. Host: Vincent Racaniello Guests: Sarah Gilbert, Florian Krammer, Fausto Baldanti, Thea Fischer, Ron Fouchier, and Catherine Moore Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Correlate of protection needed for COVID-19 vaccines (Nat Med) Simian adenoviruses as vaccine vectors (Future Viral) Early SARS-CoV-2 spread in Lombardy (Nat Comm) SA...
Source: This Week in Virology - MP3 Edition - October 7, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
