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Procedure: Transplants
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Stimulator of interferon genes (STING): Key therapeutic targets in ischemia/reperfusion injury
Biomed Pharmacother. 2023 Sep 10;167:115458. doi: 10.1016/j.biopha.2023.115458. Online ahead of print.ABSTRACTThe Stimulator of Interferon Genes (STING) is predominantly expressed in immune cells, including macrophages, natural killer cells, dendritic cells, and T cells, functioning as a pattern recognition receptor. STING activation upon detecting cytosolic DNA released from damaged cells initiates downstream pathways, leading to the production of inflammatory cytokines such as IFNs, IL-6, and TNF-α. Dysregulated STING activation has been implicated in inflammatory and metabolic diseases. Ischemia/reperfusion injury (I/R...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 12, 2023 Category: Drugs & Pharmacology Authors: Juan Lv Xuanxuan Zhu Chunlei Xing Yuhong Chen Huihui Bian Heng Yin Xiaofeng Gu Li Su Source Type: research
Machine perfusion in liver transplantation
CONCLUSIONS: In situations where the decision has been made to transplant a liver donated after circulatory death or donated following brain death, end-ischaemic HOPE will provide superior clinically relevant outcomes compared with SCS alone. Specifically, graft survival is improved (high-certainty evidence), serious adverse events are reduced (moderate-certainty evidence), and in donors after circulatory death, clinically relevant ischaemic biliary complications are reduced (high-certainty evidence). There is no good evidence that NMP has the same benefits over SCS in terms of these clinically relevant outcomes. NMP does ...
Source: Cochrane Database of Systematic Reviews - September 12, 2023 Category: General Medicine Authors: Samuel J Tingle Joseph J Dobbins Emily R Thompson Rodrigo S Figueiredo Balaji Mahendran Sanjay Pandanaboyana Colin Wilson Source Type: research
Auxiliary Partial Orthotopic Liver Transplant as a Rescue Procedure for Acute Liver Failure with Extra-Small-for-Size Grafts: A Report of 2 Cases
We present 2 cases of acute liver failure treated with auxiliary partial orthotopic liver transplant using an extra-small-for-size graft. The first case was a 12-year-old female patient who presented with druginduced acute liver failure and required an auxiliary partial orthotopic liver transplant with an extra-small left lobe graft (graft-to-recipient weight ratio of 0.45). The second case was a 23-year-old male patient with acute liver failure of unknown etiology who underwent an auxiliary partial orthotopic liver transplant with a small right lobe graft (graft-torecipient weight ratio of 0.5). In both cases, computed to...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Amith Kumar Pakkala Gaurav Chaubal Aditya Nanavati Hunaid Hatimi Rajeev Sinha Ameet Mandot Uday Sanglodkar Alisha Chaubal Harshit Chaksota Samir Shah Source Type: research
Coexistence of low muscle mass and osteoporosis as a predictor of fragility fractures in long-term kidney transplant recipients
CONCLUSION: Long-term KTRs with the coexistence of LMM and osteoporosis had an independently higher risk of fragility fractures than those without both LMM and osteoporosis. The combination of SMI and osteoporosis definitions can be used to identify KTRs with a high fracture risk.PMID:37699366 | DOI:10.1159/000534019
Source: American Journal of Nephrology - September 12, 2023 Category: Urology & Nephrology Authors: Mayuko Hori Hiroshi Takahashi Chika Kondo Yutaka Matsuoka Makoto Tsujita Morikuni Nishihira Kazuharu Uchida Asami Takeda Kunio Morozumi Shoichi Maruyama Source Type: research
Synchronous Donor Heart and Lung Procurement Does Not Impair Outcomes After Heart Transplant
CONCLUSIONS: Our study confirms that synchronous heart and lung procurement for transplant is not associated with worse outcomes in heart transplant recipients and that hearts originating from heart-andlung donors may even be associated with improved outcomes.PMID:37698403 | DOI:10.6002/ect.2023.0151
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Freya Sophie Jenkins Charlotte Boettger Moritz Benjamin Immohr Payam Akhyari Hug Aubin Igor Tudorache Dennis Sigetti Daniel Oehler Artur Lichtenberg Udo Boeken Source Type: research
Development of a Composite Recipient Comorbidity and Demographic Index for Predicting In-Hospital Mortality in Heart Transplant Patients
CONCLUSIONS: The Elixhauser Comorbidity Index is an effective measure to predict in-hospital mortality after heart transplant. The improved measure adjusted index could be used as a standardized composite score to account for recipient comorbidity and demographics across clinical studies.PMID:37698402 | DOI:10.6002/ect.2023.0134
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Renxi Li Source Type: research
Repairing Mechanisms for Distal Airway Injuries and Related Targeted Therapeutics for Chronic Lung Diseases
Cell Transplant. 2023 Jan-Dec;32:9636897231196489. doi: 10.1177/09636897231196489.ABSTRACTChronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), involve progressive and irreversible destruction and pathogenic remodeling of airways and have become the leading health care burden worldwide. Pulmonary tissue has extensive capacities to launch injury-responsive repairing programs (IRRPs) to replace the damaged or dead cells upon acute lung injuries. However, the IRRPs are frequently compromised in chronic lung diseases. In this review, we aim to provide an overview o...
Source: Cell Transplantation - September 12, 2023 Category: Cytology Authors: Huahua Xu Guihong Pan Jun Wang Source Type: research
Comparative Analysis of Donor Liver Allograft Outcomes in Hepatocellular Carcinoma Patients Who Underwent Liver Transplant
CONCLUSIONS: Similar outcomes can be achieved for hepatocellular carcinoma patients who undergo liver transplant with donations after brain death, donations after cardiac death, or donations after brain and cardiac death allografts, especially when strict donor selection criteria are applied.PMID:37698401 | DOI:10.6002/ect.2023.0119
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Abdulahad Abdulrab Mohammed Al-Ameri Zhisheng Zhou Shusen Zheng Source Type: research
Interventional Treatment Methods for Ureteral Complications After Kidney Transplant: A Single-Center Experience
CONCLUSIONS: Ureteral complications after kidney transplant can be successfully treated with interventional methods in experienced centers without the need for surgery.PMID:37698400 | DOI:10.6002/ect.2023.0236
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Özgür Özen Emre Karakaya Tolga Zeydanl ı G ökhan Kahraman Sedat Y ıldırım Fatih Boyvat Mehmet Haberal Source Type: research
Investigation of the Association Between ITPA Gene 94C & gt;A Sequence Variant and Kidney Transplant Rejection in Iranian Kidney Transplant Recipients
CONCLUSIONS: We observed no significant differences between rejection and nonrejection transplant. Further studies are recommended, in a larger population and with different ethnicities.PMID:37698399 | DOI:10.6002/ect.2023.0066
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Mozhdeh Heidari Marzieh Khalili Fardin Balouchi Jamshid Roozbeh Ali Reza Shamsaefar Seyed Ali Malek Hosseini Mohammad Hossein Karimi Source Type: research
Ureterovesical Leak Following Renal Transplant and Effects of Acute Rejection and Antirejection Therapy: A Nested Case-Control Analysis and Outcome of 1102 Consecutive Renal Transplant Recipients
CONCLUSIONS: Nontechnical risk factors that cause posttransplant ureteric leak include older donor and recipient age and ABO incompatible and 6/6 HLA mismatch transplants. Acute rejection and plasmapheresis predispose leak, and an indwelling double J stent can allow adequate healing of the anastomosis. High index of suspicion and prompt management are imperative to preserve graft and patient outcome.PMID:37698398 | DOI:10.6002/ect.2023.0004
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Akshay Kriplani Sanjoy Kumar Sureka Anil Mani Sanchit Rustagi Uday Pratap Singh M S Ansari Narayan Prasad Harshita Sharma Aneesh Srivastava Source Type: research
Corticosteroid Dose in Kidney Transplantation and Its Effect on Surgical Complication: A Systematic Review
CONCLUSIONS: We investigated the potential benefits of reducing the dose of corticosteroids following kidney transplant. Findings suggested thatreducing the dose of corticosteroids following kidney transplant might be a viable strategy for minimizing the risk of surgical complications. However, it is essential to note that the optimal dosage and duration of corticosteroid therapy after kidney transplant may vary for each patient and should be carefully determined by the health care provider.PMID:37698397 | DOI:10.6002/ect.2023.0198
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Nasser Simforoosh Amirhossein Nayebzade Mehdi Dadpour Saeed Rohani Source Type: research
Living Donor Liver Transplantation in Patients with Preformed Donor-Specific Anti-Human Leukocyte Antigen Antibodies Using Preoperative Desensitization Therapy According to Intensity of Donor-Specific Antibodies: A Single-Center Study
CONCLUSIONS Satisfactory LDLT results were achieved in DSA- and CREG-alone-positive cases following desensitization therapy.PMID:37697637 | DOI:10.12659/AOT.941346
Source: Annals of Transplantation - September 12, 2023 Category: Transplant Surgery Authors: Kohei Ogawa Kei Tamura Katsunori Sakamoto Naotake Funamizu Masahiko Honjo Mikiya Shine Yusuke Nishi Tomoyuki Nagaoka Chihiro Ito Miku Iwata Mio Uraoka Yasutsugu Takada Source Type: research
Protocol for a feasibility trial (EXPRESS-C-GVHD) for an expressive helping intervention within a support group for cutaneous graft-versus-host-disease
DISCUSSION: The EXPRESS-C-GVHD Trial is a pilot trial and will assess whether a Zoom-based expressive writing intervention within the framework of a support group is feasible and can improve QOL outcomes among individuals with cuGVHD.TRIAL REGISTRATION: The trial is registered under number NCT05694832.PMID:37698591 | DOI:10.1007/s00403-023-02718-y
Source: Cell Research - September 12, 2023 Category: Cytology Authors: Trisha Kaundinya Yae Kye Salma E El-Behaedi Jennifer N Choi Source Type: research
Is Treosulfan-Based Conditioning Attractive as a Reduced-Intensity Conditioning Regimen in Korea?
CONCLUSION: This study suggests that Treo/Flu conditioning may be an alternative to Bu/Flu regimen in elderly patients with high-risk who are not suitable for standard conditioning.PMID:37698206 | PMC:PMC10497350 | DOI:10.3346/jkms.2023.38.e281
Source: J Korean Med Sci - September 12, 2023 Category: General Medicine Authors: Se Hyung Kim Young Sok Ji Jina Yun Seong Hyeok Choi Sung Hee Lim Chan Kyu Kim Seong Kyu Park Source Type: research
