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Effects of combined strength and endurance training on exercise capacity in kidney transplant cyclists and runners
CONCLUSIONS: These findings indicate that the combined strength and endurance training is well tolerated and may improve exercise performance in this selected population of KTRs.PMID:37712239 | DOI:10.4415/ANN_23_03_07
Source: Annali dell'Istituto Superiore di Sanita - September 15, 2023 Category: International Medicine & Public Health Authors: Valentina Totti Rocco Di Michele Giulio Sergio Roi Sandro Bartolomei Giovanni Mosconi Gianluigi Sella Alessandro Nanni Costa Gabriela Sangiorgi Manuela Trerotola Lia Bellis Franco Merni Massimo Cardillo Source Type: research
Periodontal Tissue Regeneration by Transplantation of Autologous Adipose Tissue-Derived Multi-Lineage Progenitor Cells With Carbonate Apatite
In this study, we selected carbonate apatite as a candidate scaffold material for ADMPCs and conducted an in vitro examination of its effect on the cellular function of ADMPCs. We further performed autologous ADMPC transplantation with carbonate apatite as the scaffold material in a model of one-wall bone defects in beagles and then analyzed the effect on periodontal tissue regeneration. The findings showed that carbonate apatite did not affect the cell morphology of ADMPCs and that it promoted proliferation. Moreover, no effect on secretor factor transcription was found. The results of the in vivo analysis confirmed the s...
Source: Cell Transplantation - September 15, 2023 Category: Cytology Authors: Masahide Takedachi Kohsuke Kawasaki Keigo Sawada Kazuma Sakura Mari Murata Junpei Shimomura Kazuma Kawakami Chiaki Morimoto Koji Miki Noboru Takeshita Tomoaki Iwayama Hanayuki Okura Akifumi Matsuyama Masahiro Saito Masahiro Kitamura Shinya Murakami Source Type: research
Effects of combined strength and endurance training on exercise capacity in kidney transplant cyclists and runners
CONCLUSIONS: These findings indicate that the combined strength and endurance training is well tolerated and may improve exercise performance in this selected population of KTRs.PMID:37712239 | DOI:10.4415/ANN_23_03_07
Source: Ann Ist Super Sanita - September 15, 2023 Category: Biomedical Science Authors: Valentina Totti Rocco Di Michele Giulio Sergio Roi Sandro Bartolomei Giovanni Mosconi Gianluigi Sella Alessandro Nanni Costa Gabriela Sangiorgi Manuela Trerotola Lia Bellis Franco Merni Massimo Cardillo Source Type: research
Comparative efficacy of endogenous stem cells recruiting hydrogels and stem cell-loaded hydrogels in knee cartilage regeneration: a meta-analysis
Conclusion The current study indicates that both endogenous stem cell recruiting hydrogels and stem cell loaded hydrogels can effectively promote knee joint cartilage regeneration in animal trials.PMID:37711133 | DOI:10.2174/1574888X19666230914123443
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Wanyun Feng Chaohua Zhu Ruoxiang Miao Danni Li Xi Xiong Ruyu Wang Guobing Liu Jun Ma Source Type: research
PRPF31-retinitis pigmentosa: Challenges and opportunities for clinical translation
Vision Res. 2023 Sep 13;213:108315. doi: 10.1016/j.visres.2023.108315. Online ahead of print.ABSTRACTMutations in pre-mRNA processing factor 31 cause autosomal dominant retinitis pigmentosa (PRPF31-RP), for which there is currently no efficient treatment, making this disease a prime target for the development of novel therapeutic strategies. PRPF31-RP exhibits incomplete penetrance due to haploinsufficiency, in which reduced levels of gene expression from the mutated allele result in disease. A variety of model systems have been used in the investigation of disease etiology and therapy development. In this review, we discu...
Source: Vision Research - September 15, 2023 Category: Opthalmology Authors: Hamzah Aweidah Zhouhuan Xi Jos é-Alain Sahel Leah C Byrne Source Type: research
Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model
J Immunol. 2023 Sep 15:ji2300111. doi: 10.4049/jimmunol.2300111. Online ahead of print.ABSTRACTAllogeneic hematopoietic stem cell transplantation (alloSCT) is, in many clinical settings, the only curative treatment for acute myeloid leukemia (AML). The clinical benefit of alloSCT greatly relies on the graft-versus-leukemia (GVL) effect. However, AML relapse remains the top cause of posttransplant death; this highlights the urgent need to enhance GVL. Studies of human GVL have been hindered by the lack of optimal clinically relevant models. In this article, we report, the successful establishment of a novel (to our knowledg...
Source: Journal of Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Bei Jia Chenchen Zhao Kentaro Minagawa Hiroko Shike David F Claxton W Christopher Ehmann Witold B Rybka Shin Mineishi Ming Wang Todd D Schell K Sandeep Prabhu Robert F Paulson Yi Zhang Leonard D Shultz Hong Zheng Source Type: research
Effects of combined strength and endurance training on exercise capacity in kidney transplant cyclists and runners
CONCLUSIONS: These findings indicate that the combined strength and endurance training is well tolerated and may improve exercise performance in this selected population of KTRs.PMID:37712239 | DOI:10.4415/ANN_23_03_07
Source: Ann Ist Super Sanita - September 15, 2023 Category: Biomedical Science Authors: Valentina Totti Rocco Di Michele Giulio Sergio Roi Sandro Bartolomei Giovanni Mosconi Gianluigi Sella Alessandro Nanni Costa Gabriela Sangiorgi Manuela Trerotola Lia Bellis Franco Merni Massimo Cardillo Source Type: research
Periodontal Tissue Regeneration by Transplantation of Autologous Adipose Tissue-Derived Multi-Lineage Progenitor Cells With Carbonate Apatite
In this study, we selected carbonate apatite as a candidate scaffold material for ADMPCs and conducted an in vitro examination of its effect on the cellular function of ADMPCs. We further performed autologous ADMPC transplantation with carbonate apatite as the scaffold material in a model of one-wall bone defects in beagles and then analyzed the effect on periodontal tissue regeneration. The findings showed that carbonate apatite did not affect the cell morphology of ADMPCs and that it promoted proliferation. Moreover, no effect on secretor factor transcription was found. The results of the in vivo analysis confirmed the s...
Source: Cell Transplantation - September 15, 2023 Category: Cytology Authors: Masahide Takedachi Kohsuke Kawasaki Keigo Sawada Kazuma Sakura Mari Murata Junpei Shimomura Kazuma Kawakami Chiaki Morimoto Koji Miki Noboru Takeshita Tomoaki Iwayama Hanayuki Okura Akifumi Matsuyama Masahiro Saito Masahiro Kitamura Shinya Murakami Source Type: research
Effects of combined strength and endurance training on exercise capacity in kidney transplant cyclists and runners
CONCLUSIONS: These findings indicate that the combined strength and endurance training is well tolerated and may improve exercise performance in this selected population of KTRs.PMID:37712239 | DOI:10.4415/ANN_23_03_07
Source: Ann Ist Super Sanita - September 15, 2023 Category: Biomedical Science Authors: Valentina Totti Rocco Di Michele Giulio Sergio Roi Sandro Bartolomei Giovanni Mosconi Gianluigi Sella Alessandro Nanni Costa Gabriela Sangiorgi Manuela Trerotola Lia Bellis Franco Merni Massimo Cardillo Source Type: research
Comparative efficacy of endogenous stem cells recruiting hydrogels and stem cell-loaded hydrogels in knee cartilage regeneration: a meta-analysis
Conclusion The current study indicates that both endogenous stem cell recruiting hydrogels and stem cell loaded hydrogels can effectively promote knee joint cartilage regeneration in animal trials.PMID:37711133 | DOI:10.2174/1574888X19666230914123443
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Wanyun Feng Chaohua Zhu Ruoxiang Miao Danni Li Xi Xiong Ruyu Wang Guobing Liu Jun Ma Source Type: research
Reviewing Evidence for Urolithin A Supplementation
Mitochondria are the power plants of the cell, responsible for generating chemical energy store molecules to power cell processes. Urolithin A is one of a number of supplements shown to improve mitochondrial function, though as for the others it isn't all that impressive when compared to the effects of regular exercise. Nonetheless, this and other approaches to modestly attenuate age-related declines in mitochondrial function are under active development. They are not solutions to the problem of mitochondrial aging, however. For that we must look to more radical approaches to therapy, such as mitochondrial transplantation,...
Source: Fight Aging! - September 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Single-Cell RNA Sequencing of Coronary Perivascular Adipose Tissue From End-Stage Heart Failure Patients Identifies < em > SPP1 < /em > < sup > + < /sup > Macrophage Subpopulation as a Target for Alleviating Fibrosis
CONCLUSIONS: SPP1+ macrophages accumulated in the PVAT surrounding atherosclerotic coronary arteries, and they promoted the migration and proliferation of fibroadipogenic progenitor cells via OPN-CD44/integrin interaction and thus aggravated the fibrosis of coronary PVAT, which was positively correlated to the coronary stenosis burden. Therefore, SPP1+ macrophages in coronary PVAT may participate in the progression of coronary atherosclerosis.PMID:37706320 | DOI:10.1161/ATVBAHA.123.319828
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Mengxia Fu Songren Shu Zhiming Peng Xiaorui Liu Xiao Chen Zhiwei Zeng Yicheng Yang Hao Cui Ruojin Zhao Xiaohu Wang Leilei Du Min Wu Wei Feng Jiangping Song Source Type: research
