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Outpatient Treatment of Confirmed COVID-19: A Living, Rapid Evidence Review for the American College of Physicians (Version 2)
CONCLUSION: Nirmatrelvir-ritonavir and molnupiravir probably improve outcomes for outpatients with mild to moderate COVID-19.PRIMARY FUNDING SOURCE: American College of Physicians. (PROSPERO: CRD42023406456).PMID:37722115 | DOI:10.7326/M23-1626
Source: Annals of Internal Medicine - September 18, 2023 Category: Internal Medicine Authors: Isolde Sommer Dominic Ledinger Kylie Thaler Andreea Dobrescu Emma Persad Martin Fangmeyer Irma Klerings Gerald Gartlehner Source Type: research

Outpatient Treatment of Confirmed COVID-19: Living, Rapid Practice Points From the American College of Physicians (Version 2)
Ann Intern Med. 2023 Sep 19. doi: 10.7326/M23-1636. Online ahead of print.ABSTRACTDESCRIPTION: Evidence for the use of outpatient treatments in adults with confirmed COVID-19 continues to evolve with new data. This is version 2 of the American College of Physicians (ACP) living, rapid practice points focusing on 22 outpatient treatments for COVID-19, specifically addressing the dominant SARS-CoV-2 Omicron variant.METHODS: The Population Health and Medical Science Committee (formerly the Scientific Medical Policy Committee) developed this version of the living, rapid practice points on the basis of a living, rapid review do...
Source: Annals of Internal Medicine - September 18, 2023 Category: Internal Medicine Authors: Amir Qaseem Jennifer Yost George M Abraham Rebecca Andrews Janet A Jokela Matthew C Miller Linda L Humphrey Population Health and Medical Science Committee of the American College of Physicians Source Type: research

Case report on meningoenceplapathy in an Indian patient post CoViD vaccination
Bioinformation. 2023 Jan 31;19(1):117-119. doi: 10.6026/97320630019117. eCollection 2023.ABSTRACTThe SARS-COV-2 infection-related severe illness is prevented by vaccinations. Therefore, it is relevant to report a case of post vaccine meningoencephalitis in a 30 year old male Indian patient, who presented with weakness in all the extremities, episodes of loose stool, fever, vomiting, tachypnea and loss of consciousness immediately following the 2nd dose of the COVID vaccination (COVAXIN).PMID:37720286 | PMC:PMC10504505 | DOI:10.6026/97320630019117
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Raj Kamal Choudhry Amrendra Kumar Singh Kumar Sourav Anjum Pervez Abilesh Kumar Subham Kumar Source Type: research

Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Structure adaptation in Omicron SARS-CoV-2/hACE2: Biophysical origins of evolutionary driving forces
Biophys J. 2023 Sep 15:S0006-3495(23)00580-5. doi: 10.1016/j.bpj.2023.09.003. Online ahead of print.ABSTRACTSince its emergence, the COVID-19 threat has been sustained by a series of transmission waves initiated by new variants of the SARS-CoV-2 virus. Some of these arise with higher transmissivity and/or increased disease severity. Here we use molecular dynamics simulations to examine the modulation of the fundamental interactions between the receptor binding domain (RBD) of the spike glycoprotein and the host cell receptor (human angiotensin-converting enzyme 2: hACE2) arising from Omicron variant mutations (BA.1 and BA....
Source: Biophysical Journal - September 17, 2023 Category: Physics Authors: Ya-Wen Hsiao David J Bray Tseden Taddese Guadalupe Jim énez-Serratos Jason Crain Source Type: research

Building parameters linked with indoor transmission of SARS-CoV-2
Environ Res. 2023 Sep 15:117156. doi: 10.1016/j.envres.2023.117156. Online ahead of print.ABSTRACTThe rapid spread of Coronavirus Disease (2019)(COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emphasized the importance of understanding and adapting to the indoor remediation of transmissible diseases to decrease the risk for future pandemic threats. While there were many precautions in place to hinder the spread of COVID-19, there has also been a substantial increase of new research on SARS-CoV-2 that can be utilized to further mitigate the transmission risk of this novel virus. This r...
Source: Environmental Research - September 17, 2023 Category: Environmental Health Authors: Jacqueline Horne Nicholas Dunne Nirmala Singh Md Safiuddin Navid Esmaeili Merve Erenler Ian Ho Edwin Luk Source Type: research

Protocol for a living evidence synthesis on variants of concern and COVID-19 vaccine effectiveness
DISCUSSION: Evidence generated from our living evidence synthesis will be used to inform policy making, modelling, and prioritization of future research on the effectiveness of COVID-19 vaccines against VOC.PMID:37718186 | DOI:10.1016/j.vaccine.2023.09.012
Source: Vaccine - September 17, 2023 Category: Allergy & Immunology Authors: Nicole Shaver Melanie Katz Gideon Darko Asamoah Lori-Ann Linkins Wael Abdelkader Andrew Beck Alexandria Bennett Sarah E Hughes Maureen Smith Mpho Begin Doug Coyle Thomas Piggott Benjamin M Kagina Vivian Welch Caroline Colijn David J D Earn Khaled El Emam Source Type: research

Structure adaptation in Omicron SARS-CoV-2/hACE2: Biophysical origins of evolutionary driving forces
Biophys J. 2023 Sep 15:S0006-3495(23)00580-5. doi: 10.1016/j.bpj.2023.09.003. Online ahead of print.ABSTRACTSince its emergence, the COVID-19 threat has been sustained by a series of transmission waves initiated by new variants of the SARS-CoV-2 virus. Some of these arise with higher transmissivity and/or increased disease severity. Here we use molecular dynamics simulations to examine the modulation of the fundamental interactions between the receptor binding domain (RBD) of the spike glycoprotein and the host cell receptor (human angiotensin-converting enzyme 2: hACE2) arising from Omicron variant mutations (BA.1 and BA....
Source: Biophysical Journal - September 17, 2023 Category: Physics Authors: Ya-Wen Hsiao David J Bray Tseden Taddese Guadalupe Jim énez-Serratos Jason Crain Source Type: research

Regulation of SARS-CoV-2 infection and antiviral innate immunity by ubiquitination and ubiquitin-like conjugation
Biochim Biophys Acta Gene Regul Mech. 2023 Sep 15:194984. doi: 10.1016/j.bbagrm.2023.194984. Online ahead of print.ABSTRACTA global pandemic COVID-19 resulting from SARS-CoV-2 has affected a significant portion of the human population. Antiviral innate immunity is critical for controlling and eliminating the viral infection. Ubiquitination is extensively involved in antiviral signaling, and recent studies suggest that ubiquitin-like proteins (Ubls) modifications also participate in innate antiviral pathways such as RLR and cGAS-STING pathways. Notably, virus infection harnesses ubiquitination and Ubls modifications to faci...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Yi Zheng Huiyu Yang Xuejing Zhang Chengjiang Gao Source Type: research

Examining the Influence of Imbalanced Social Contact Matrices in Epidemic Models
Am J Epidemiol. 2023 Sep 15:kwad185. doi: 10.1093/aje/kwad185. Online ahead of print.ABSTRACTTransmissible infections such as those caused by SARS-CoV-2 spread according to who contacts whom. Therefore, many epidemic models incorporate contact patterns through contact matrices. Contact matrices can be generated from social contact survey data. However, the resulting matrices are often imbalanced, such that the total number of contacts reported by group A with group B do not match those reported by group B with group A. We examine the theoretical influence of imbalanced contact matrices on the estimated basic reproduction n...
Source: Am J Epidemiol - September 16, 2023 Category: Epidemiology Authors: Mackenzie Hamilton Jesse Knight Sharmistha Mishra Source Type: research

Recombinant Antibodies to Face SARS-CoV-2 Syndemic
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):24-27. doi: 10.14715/cmb/2023.69.7.4.ABSTRACTIn recent years, increasing interest has been paid to using antibody-based therapies for clinical applications. However, it is unclear whether recombinant antibodies can be combined with other scientific approaches to generate innovative solutions for mitigating severe acute respiratory syndrome coronavirus 2. In this context, the increase in this virus transmission, the number of infected people, and the interaction between social and biological processes have led to a syndemic, exacerbating the public health problem. Here, we a...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Maykel Gonz ález Torres Gerardo Leyva G ómez Mar ía Luisa Del Prado-Audelo Hern án Cortés Jonathan J Maga ña Source Type: research