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Infectious Disease: SARS
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Total 80785 results found since Jan 2013.
Obtaining a high titer of polyclonal antibodies from rats to the SARS-CoV-2 nucleocapsid protein and its N- and C-terminal domains for diagnostic test development
J Immunol Methods. 2023 Sep 11:113558. doi: 10.1016/j.jim.2023.113558. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an enveloped, plus-stranded RNA virus responsible for the Coronavirus Disease 2019 (COVID-19). Patients infected with COVID-19 may be asymptomatic or have symptoms ranging from mild manifestations to severe cases of the disease that could lead to death. The SARS-CoV-2 genome encodes 4 structural proteins, including the Spike protein (S), the Nucleocapsid protein (N), membrane protein (M) and, the envelope (E). The N protein forms a major component of the ribonu...
Source: Journal of Immunological Methods - September 13, 2023 Category: Allergy & Immunology Authors: Michelle Teixeira de Almeida Ana Paula Barbosa Camila Gasque Bomfim Aline Biazola Visnardi Tania Churasacari Vinces Alexandre Ceroni Edison Luiz Durigon Cristiane Rodrigues Guzzo Source Type: research
Inflammasome activation by SARS-CoV-2 and its participation in COVID-19 exacerbation
Curr Opin Immunol. 2023 Sep 11;84:102387. doi: 10.1016/j.coi.2023.102387. Online ahead of print.ABSTRACTCOVID-19 is an infectious and inflammatory disease caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus-2) that might progress to severe illness in humans, characterized by excessive pulmonary and systemic inflammation. Exacerbated production of inflammatory cytokines and cell death contributes to disease aggravation and the inflammasomes take a central stage in this process. Activation of the NLRP3 has been demonstrated in macrophages and monocytes infected in vitro, in mouse models of infection, and in c...
Source: Current Opinion in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Tamara S Rodrigues Dario S Zamboni Source Type: research
Computational Study on the Mechanisms of Inhibition of SARS-CoV-2 Mpro by Aldehyde Warhead Based on DFT
In this study, a simplified model obtained through truncation... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - September 13, 2023 Category: Chemistry Authors: Yongsheng Yang Source Type: research
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits viral-induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2
CONCLUSION: By virtue of its ability to modulate epithelial ACE2 expression and inhibit virus-mediated pro-inflammatory cytokine release, FXR represents a promising target for development of new approaches to prevent intestinal manifestations of SARS-CoV-2.PMID:37697930 | DOI:10.1152/ajpgi.00099.2023
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 12, 2023 Category: Physiology Authors: Jessica S Smyth Jennifer K Truong Anuradha Rao Jennifer Foulke-Abel Luciano Adorini Mark Donowitz Paul A Dawson Stephen J Keely Source Type: research
Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation
This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:37699145 | DOI:10.1165/rcmb.2023-0104OC
Source: Am J Respir Cell Mol... - September 12, 2023 Category: Respiratory Medicine Authors: Kamakshi Bankoti Wei Wang Gaurang M Amonkar Linjie Xiong Jessica E Shui Caiqi Zhao Eric Van Chimwemwe Mwase Jin-Ah Park Hongmei Mou Yinshan Fang Jianwen Que Yan Bai Paul H Lerou Xingbin Ai Source Type: research
Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
Life Sci Alliance. 2023 Sep 12;6(11):e202302106. doi: 10.26508/lsa.202302106. Print 2023 Nov.ABSTRACTPreviously, we and others have shown that SARS-CoV-2 spike-specific IgG antibodies play a major role in disease severity in COVID-19 by triggering macrophage hyperactivation, disrupting endothelial barrier integrity, and inducing thrombus formation. This hyperinflammation is dependent on high levels of anti-spike IgG with aberrant Fc tail glycosylation, leading to Fcγ receptor hyperactivation. For development of immune-regulatory therapeutics, drug specificity is crucial to counteract excessive inflammation whereas simulta...
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Chiara E Geyer Hung-Jen Chen Alexander P Bye Xue D Manz Denise Guerra Tom G Caniels Tom Pl Bijl Guillermo R Griffith Willianne Hoepel Steven W de Taeye Jennifer Veth Alexander Pj Vlaar Amsterdam UMC COVID-19 Biobank Gestur Vidarsson Harm Jan Bogaard Jurja Source Type: research
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits viral-induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2
CONCLUSION: By virtue of its ability to modulate epithelial ACE2 expression and inhibit virus-mediated pro-inflammatory cytokine release, FXR represents a promising target for development of new approaches to prevent intestinal manifestations of SARS-CoV-2.PMID:37697930 | DOI:10.1152/ajpgi.00099.2023
Source: Am J Physiol Gastroi... - September 12, 2023 Category: Gastroenterology Authors: Jessica S Smyth Jennifer K Truong Anuradha Rao Jennifer Foulke-Abel Luciano Adorini Mark Donowitz Paul A Dawson Stephen J Keely Source Type: research
Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation
This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:37699145 | DOI:10.1165/rcmb.2023-0104OC
Source: Am J Respir Cell Mol... - September 12, 2023 Category: Respiratory Medicine Authors: Kamakshi Bankoti Wei Wang Gaurang M Amonkar Linjie Xiong Jessica E Shui Caiqi Zhao Eric Van Chimwemwe Mwase Jin-Ah Park Hongmei Mou Yinshan Fang Jianwen Que Yan Bai Paul H Lerou Xingbin Ai Source Type: research
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits viral-induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2
CONCLUSION: By virtue of its ability to modulate epithelial ACE2 expression and inhibit virus-mediated pro-inflammatory cytokine release, FXR represents a promising target for development of new approaches to prevent intestinal manifestations of SARS-CoV-2.PMID:37697930 | DOI:10.1152/ajpgi.00099.2023
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 12, 2023 Category: Physiology Authors: Jessica S Smyth Jennifer K Truong Anuradha Rao Jennifer Foulke-Abel Luciano Adorini Mark Donowitz Paul A Dawson Stephen J Keely Source Type: research
Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
Life Sci Alliance. 2023 Sep 12;6(11):e202302106. doi: 10.26508/lsa.202302106. Print 2023 Nov.ABSTRACTPreviously, we and others have shown that SARS-CoV-2 spike-specific IgG antibodies play a major role in disease severity in COVID-19 by triggering macrophage hyperactivation, disrupting endothelial barrier integrity, and inducing thrombus formation. This hyperinflammation is dependent on high levels of anti-spike IgG with aberrant Fc tail glycosylation, leading to Fcγ receptor hyperactivation. For development of immune-regulatory therapeutics, drug specificity is crucial to counteract excessive inflammation whereas simulta...
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Chiara E Geyer Hung-Jen Chen Alexander P Bye Xue D Manz Denise Guerra Tom G Caniels Tom Pl Bijl Guillermo R Griffith Willianne Hoepel Steven W de Taeye Jennifer Veth Alexander Pj Vlaar Amsterdam UMC COVID-19 Biobank Gestur Vidarsson Harm Jan Bogaard Jurja Source Type: research
An overview of protein-based SARS-CoV-2 vaccines
Vaccine. 2023 Sep 10:S0264-410X(23)01067-8. doi: 10.1016/j.vaccine.2023.09.013. Online ahead of print.ABSTRACTSARS-CoV-2 resulted in the COVID-19 pandemic which, to date, has resulted in an estimated loss of over 15 million human lives globally and continues to have negative social, and economic implications worldwide. Vaccine platforms that can be quickly updated to counter newly emerging SARS-CoV-2 variants are critical in combating the COVID-19 pandemic. Messenger RNA-based SARS-CoV-2 vaccines can be easily updated and have shown superior efficacy over other vaccine types, yet their high cost, reactogenicity, and string...
Source: Vaccine - September 12, 2023 Category: Allergy & Immunology Authors: Yogesh R Suryawanshi Source Type: research
