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Total 80785 results found since Jan 2013.
Second Phase of the NIH Preprint Pilot Launched
Today, we are pleased to announce the launch of the second phase of the NIH Preprint Pilot with the addition of more than 700 new preprint records to PubMed Central (PMC) and PubMed. This second phase expands the scope of the Pilot to include preprints resulting from all NIH-funded research. Eligible preprints are those acknowledging direct support of an NIH award or authored by NIH staff and posted to bioRxiv, medRxiv, arXiv, or Research Square, on or after January 1, 2023. NLM will automatically include the full text of the preprint (as license terms allow) and associated citation information in PMC and PubMed, respectiv...
Source: PubMed Central News - January 30, 2023 Category: Databases & Libraries Source Type: news
Efficacy and safety of decontamination for N95 respirator reuse: a systematic literature search and narrative synthesis.
CONCLUSIONS: N95 mask reprocessing using either moist heat or vaporous hydrogen peroxide is recommended to ensure healthcare worker safety.
PMID: 32720256 [PubMed - as supplied by publisher]
Source: Canadian Journal of Anaesthesia - July 26, 2020 Category: Anesthesiology Authors: Steinberg BE, Aoyama K, McVey M, Levin D, Siddiqui A, Munshey F, Goldenberg NM, Faraoni D, Maynes JT Tags: Can J Anaesth Source Type: research
Loss of smell and taste: a new marker of COVID-19? Tracking reduced sense of smell during the coronavirus pandemic using search trends.
CONCLUSIONS: We feel that Google search trends relating to loss of smell can be utilized to identify potential Covid-19 outbreaks on a national and regional basis.
PMID: 32673122 [PubMed - as supplied by publisher]
Source: Expert Review of Anti-Infective Therapy - July 18, 2020 Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Efficacy and safety of decontamination for N95 respirator reuse: a systematic literature search and narrative synthesis
ConclusionsN95 mask reprocessing using either moist heat or vaporous hydrogen peroxide is recommended to ensure healthcare worker safety.
Source: Canadian Journal of Anesthesia - December 1, 2020 Category: Anesthesiology Source Type: research
Scoping Review on Search Queries and Social Media for Disease Surveillance: A Chronology of Innovation
Conclusions: The use of search queries and social media for disease surveillance are relatively recent phenomena (first reported in 2006). Both the tools themselves and the methodologies for exploiting them are evolving over time. While their accuracy, speed, and cost compare favorably with existing surveillance systems, the primary challenge is to refine the data signal by reducing surrounding noise. Further developments in digital disease surveillance have the potential to improve sensitivity and specificity, passively through advances in machine learning and actively through engagement of users. Adoption, even as suppor...
Source: Journal of Medical Internet Research - July 18, 2013 Category: Journals (General) Authors: Theresa Marie BernardoAndrijana RajicIan YoungKatie RobiadekMai T PhamJulie A Funk Source Type: research
Crystallographic molecular replacement using an in silico ‐generated search model of SARS‐CoV‐2 ORF8
This article is protected by copyright. All rights reserved.
Source: Protein Science - February 25, 2021 Category: Biochemistry Authors: Thomas G. Flower,
James H. Hurley Tags: Accelerated Communication Source Type: research
Flu and cold top the 2013 chart of medical search terms
The top 10 trending health issues of 2013 have been released by Google, and top of the list of searches are flu and cold, with labor coming in at third place.The results are found in the year-end zeitgeist, the search giant's annual "spirit of the times" analysis. The appearance of the term labor as a highly popular search in the health issues list comes as "royal baby" made it to seventh place in the total Google search activity across 2013, a chart topped by "Nelson Mandela.
Source: Health News from Medical News Today - December 23, 2013 Category: Consumer Health News Tags: Flu / Cold / SARS Source Type: news
Supercomputing Pipelines Search for Therapeutics Against COVID-19
The urgent search for drugs to combat SARS-CoV-2 has included the use of supercomputers. The use of general-purpose graphical processing units (GPUs), massive parallelism, and new software for high-performance computing (HPC) has allowed researchers to search the vast chemical space of potential drugs faster than ever before. We developed a new drug discovery pipeline using the Summit supercomputer at Oak Ridge National Laboratory to help pioneer this effort, with new platforms that incorporate GPU-accelerated simulation and allow for the virtual screening of billions of potential drug compounds in days compared to weeks o...
Source: Computing in Science and Engineering - March 2, 2021 Category: Information Technology Source Type: research
Google Health and Ascension Are Piloting A Cross-Platform EHR Search Tool That Helps Physicians Locate and View Patient Data, Including Clinical Laboratory Test Results
‘Care Studio’ is designed to give physicians a ‘single, centralized view’ of patients’ records that are spread among multiple disparate databases within a healthcare system Lack of interoperability between electronic health records (EHRs) has been a thorn in the side of healthcare providers—including clinical laboratorians and pathologists—who have to search multiple healthcare organizations’ databases to […]
The post Google Health and Ascension Are Piloting A Cross-Platform EHR Search Tool That Helps Physicians Locate and View Patient Data, Including Clinical Laboratory Test Results appeared first on Dark Daily.
Source: Dark Daily - April 12, 2021 Category: Laboratory Medicine Authors: Jude Tags: Digital Pathology Laboratory Management and Operations Laboratory News Laboratory Operations Laboratory Pathology clinical laboratory David Feinberg MD electronic health record SARS-CoV-2 Source Type: news
Continuous development of the semantic search engine preVIEW: from COVID-19 to long COVID
AbstractpreVIEW is a freely available semantic search engine for Coronavirus disease (COVID-19)-related preprint publications. Currently, it contains>43 800 documents indexed with>4000 semantic concepts, annotated automatically. During the last 2 years, the dynamic situation of the corona crisis has demanded dynamic development. Whereas new semantic concepts have been added over time —such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of interest—the service has been also extended with several features improving the usability and user friendliness. Most importantly, the user is n...
Source: Database : The Journal of Biological Databases and Curation - July 1, 2022 Category: Databases & Libraries Source Type: research
In the search of potential epitopes for Wuhan seafood market pneumonia virus using high order nullomers.
Abstract
Alarms periodically emerge for viral pneumonia infections due to coronavirus. In all cases, these are zoonoses passing the barrier between species and infect humans. The legitimate concern of the international community is due to the fact that the new identified coronavirus, named SARS-CoV-2 (previously called 2019-nCoV), has a quite high mortality rate, around 2%, and a strong ability to spread, with an estimated reproduction number higher than 2. Even though all countries are doing their utmost to stop the pandemic, the only reliable solution to tackle the infection is the rapid development of a vaccine...
Source: Journal of Immunological Methods - April 22, 2020 Category: Allergy & Immunology Authors: Santoni D, Vergni D Tags: J Immunol Methods Source Type: research
Development of a simple, interpretable and easily transferable QSAR model for quick screening antiviral databases in search of novel 3C-like protease (3CLpro) enzyme inhibitors against SARS-CoV diseases.
Abstract
In the context of recently emerged pandemic of COVID-19, we have performed two-dimensional quantitative structure-activity relationship (2D-QSAR) modelling using SARS-CoV-3CLpro enzyme inhibitors for the development of a multiple linear regression (MLR) based model. We have used 2D descriptors with an aim to develop an easily interpretable, transferable and reproducible model which may be used for quick prediction of SAR-CoV-3CLpro inhibitory activity for query compounds in the screening process. Based on the insights obtained from the developed 2D-QSAR model, we have identified the structural features re...
Source: SAR and QSAR in Environmental Research - June 15, 2020 Category: Environmental Health Authors: Kumar V, Roy K Tags: SAR QSAR Environ Res Source Type: research
New substance library to accelerate the search for active compounds
(Helmholtz-Zentrum Berlin f ü r Materialien und Energie) The MX team at HZB and a Group at the University of Marburg have established a new substance library. It consists of 1103 organic molecules that could be used as building blocks for new drugs. Now, this library has been validated at MAX IV. The substance library of the HZB is available for research worldwide and also plays a role in the search for active substances against SARS-CoV-19.
Source: EurekAlert! - Medicine and Health - July 13, 2020 Category: International Medicine & Public Health Source Type: news
Computational search for potential COVID-19 drugs from FDAapproved drugs and small molecules of natural origin identifies several anti-virals and plant products.
Abstract
The world is currently facing the COVID-19 pandemic, for which mild symptoms include fever and dry cough. In severe cases, it could lead to pneumonia and ultimately death in some instances. Moreover, the causative pathogen is highly contagious and there are no drugs or vaccines for it yet. The pathogen, SARS-CoV-2, is one of the human coronaviruses which was identified to infect humans first in December 2019. SARS-CoV-2 shares evolutionary relationship to other highly pathogenic viruses such as Severe Acute Respiratory Syndrome (SARS) and Middle East respiratory syndrome (MERS). We have exploited this sim...
Source: Journal of Biosciences - July 29, 2020 Category: Biomedical Science Authors: Sharma A, Tiwari V, Sowdhamini R Tags: J Biosci Source Type: research
Structure-based drug repositioning over the human TMPRSS2 protease domain: search for chemical probes able to repress SARS-CoV-2 Spike protein cleavages.
Abstract
In December 2019, a new coronavirus was identified in the Hubei province of central china and named SARS-CoV-2. This new virus induces COVID-19, a severe respiratory disease with high death rate. A putative target to interfere with the virus is the host transmembrane serine protease family member II (TMPRSS2). This enzyme is critical for the entry of coronaviruses into human cells by cleaving and activating the spike protein (S) of SARS-CoV-2. Repositioning approved, investigational and experimental drugs on the serine protease domain of TMPRSS2 could thus be valuable. There is no experimental structure f...
Source: European Journal of Pharmaceutical Sciences - July 26, 2020 Category: Drugs & Pharmacology Authors: Singh N, Decroly E, Khatib AM, Villoutreix BO Tags: Eur J Pharm Sci Source Type: research
