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Cancer: Hepatocellular Carcinoma
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Total 30263 results found since Jan 2013.
Upregulation of FAM134B inhibits endoplasmic reticulum stress-related degradation protein expression and promotes hepatocellular carcinogenesis
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17964. Online ahead of print.ABSTRACTEndoplasmic reticulum (ER) stress can stimulate the proliferation and metastasis of hepatocellular carcinoma (HCC) cells while hindering apoptosis and immune system function, but the molecular mechanism of ER stress in HCC has yet to be fully studied. We aim to investigate the molecular mechanism by which FAM134B inhibits autophagy of HCC cells by reducing the expression of ER stress-related degradation proteins. Clinical samples were collected for this study. Normal liver cell lines HL7702 and Hep3B and Huh7 HCC cell lines were cultured. C...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Houhong Wang Lu Liu Huihui Gong Heng Li Source Type: research
Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directions
Biomed Pharmacother. 2023 Sep 18;167:115538. doi: 10.1016/j.biopha.2023.115538. Online ahead of print.ABSTRACTTripartite motif (TRIM) family is assigned to RING-finger-containing ligases harboring the largest number of proteins in E3 ubiquitin ligating enzymes. E3 ubiquitin ligases target the specific substrate for proteasomal degradation via the ubiquitin-proteasome system (UPS), which seems to be a more effective and direct strategy for tumor therapy. Recent advances have demonstrated that TRIM genes associate with the occurrence and progression of hepatocellular carcinoma (HCC). TRIMs trigger or inhibit multiple biologi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Jie Zhang Yuting Zhou Jiao Feng Xuanfu Xu Jianye Wu Chuanyong Guo Source Type: research
Upregulation of FAM134B inhibits endoplasmic reticulum stress-related degradation protein expression and promotes hepatocellular carcinogenesis
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17964. Online ahead of print.ABSTRACTEndoplasmic reticulum (ER) stress can stimulate the proliferation and metastasis of hepatocellular carcinoma (HCC) cells while hindering apoptosis and immune system function, but the molecular mechanism of ER stress in HCC has yet to be fully studied. We aim to investigate the molecular mechanism by which FAM134B inhibits autophagy of HCC cells by reducing the expression of ER stress-related degradation proteins. Clinical samples were collected for this study. Normal liver cell lines HL7702 and Hep3B and Huh7 HCC cell lines were cultured. C...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Houhong Wang Lu Liu Huihui Gong Heng Li Source Type: research
Interplay between SUMO1-related SUMOylation and phosphorylation of p65 promotes hepatocellular carcinoma progression
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119595. doi: 10.1016/j.bbamcr.2023.119595. Online ahead of print.ABSTRACTThe nuclear factor kappaB (NF-κB) subunit p65, plays an important role in the progression of hepatocellular carcinoma (HCC). Phosphorylation of p65 is considered as an important mechanism for the positive regulation of NF-κB activity. According to our previous data, p65 can be SUMOylated by small ubiquitin-related modifier 1 (SUMO1) protein, and SUMO1 promotes p65 nuclear import and HCC progression. However, the effect of SUMO1-related p65 SUMOylation on NF-κB transcriptional activity and the relations...
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Can Jiang Chunyang Zhang Min Dai Fuyan Wang Sa Xu Dan Han Yanyan Wang Yajie Cao Yanyan Liang Ziyu Zhang Lina Yan Yujun Shen Kewu He Yuxian Shen Jun Liu Source Type: research
Outcomes of patients with Child-Pugh B and unresectable hepatocellular carcinoma undergoing first-line systemic treatment with sorafenib, lenvatinib, or atezolizumab plus bevacizumab
CONCLUSION: Determining the hepatic reserve of patients with unresectable HCC might be useful for identifying patents suitable for systemic treatment for HCC. Atezo + Bev might prolong the PFS of patients with a Child-Pugh score of 7.PMID:37729889 | DOI:10.1159/000533859
Source: Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Chihiro Kikugawa Shinsuke Uchikawa Tomokazu Kawaoka Takahiro Kinami Shigeki Yano Kei Amioka Kensuke Naruto Yuwa Ando Kenji Yamaoka Masataka Tsuge Yumi Kosaka Kazuki Ohya Nami Mori Shintaro Takaki Keiji Tsuji Hirotaka Kouno Hiroshi Kohno Kei Morio Takashi Source Type: research
Upregulation of FAM134B inhibits endoplasmic reticulum stress-related degradation protein expression and promotes hepatocellular carcinogenesis
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17964. Online ahead of print.ABSTRACTEndoplasmic reticulum (ER) stress can stimulate the proliferation and metastasis of hepatocellular carcinoma (HCC) cells while hindering apoptosis and immune system function, but the molecular mechanism of ER stress in HCC has yet to be fully studied. We aim to investigate the molecular mechanism by which FAM134B inhibits autophagy of HCC cells by reducing the expression of ER stress-related degradation proteins. Clinical samples were collected for this study. Normal liver cell lines HL7702 and Hep3B and Huh7 HCC cell lines were cultured. C...
Source: J Cell Mol Med - September 20, 2023 Category: Molecular Biology Authors: Houhong Wang Lu Liu Huihui Gong Heng Li Source Type: research
Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directions
Biomed Pharmacother. 2023 Sep 18;167:115538. doi: 10.1016/j.biopha.2023.115538. Online ahead of print.ABSTRACTTripartite motif (TRIM) family is assigned to RING-finger-containing ligases harboring the largest number of proteins in E3 ubiquitin ligating enzymes. E3 ubiquitin ligases target the specific substrate for proteasomal degradation via the ubiquitin-proteasome system (UPS), which seems to be a more effective and direct strategy for tumor therapy. Recent advances have demonstrated that TRIM genes associate with the occurrence and progression of hepatocellular carcinoma (HCC). TRIMs trigger or inhibit multiple biologi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Jie Zhang Yuting Zhou Jiao Feng Xuanfu Xu Jianye Wu Chuanyong Guo Source Type: research
Outcomes of patients with Child-Pugh B and unresectable hepatocellular carcinoma undergoing first-line systemic treatment with sorafenib, lenvatinib, or atezolizumab plus bevacizumab
CONCLUSION: Determining the hepatic reserve of patients with unresectable HCC might be useful for identifying patents suitable for systemic treatment for HCC. Atezo + Bev might prolong the PFS of patients with a Child-Pugh score of 7.PMID:37729889 | DOI:10.1159/000533859
Source: Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Chihiro Kikugawa Shinsuke Uchikawa Tomokazu Kawaoka Takahiro Kinami Shigeki Yano Kei Amioka Kensuke Naruto Yuwa Ando Kenji Yamaoka Masataka Tsuge Yumi Kosaka Kazuki Ohya Nami Mori Shintaro Takaki Keiji Tsuji Hirotaka Kouno Hiroshi Kohno Kei Morio Takashi Source Type: research
Interplay between SUMO1-related SUMOylation and phosphorylation of p65 promotes hepatocellular carcinoma progression
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119595. doi: 10.1016/j.bbamcr.2023.119595. Online ahead of print.ABSTRACTThe nuclear factor kappaB (NF-κB) subunit p65, plays an important role in the progression of hepatocellular carcinoma (HCC). Phosphorylation of p65 is considered as an important mechanism for the positive regulation of NF-κB activity. According to our previous data, p65 can be SUMOylated by small ubiquitin-related modifier 1 (SUMO1) protein, and SUMO1 promotes p65 nuclear import and HCC progression. However, the effect of SUMO1-related p65 SUMOylation on NF-κB transcriptional activity and the relations...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Can Jiang Chunyang Zhang Min Dai Fuyan Wang Sa Xu Dan Han Yanyan Wang Yajie Cao Yanyan Liang Ziyu Zhang Lina Yan Yujun Shen Kewu He Yuxian Shen Jun Liu Source Type: research
Network meta-analysis of adjuvant treatments for patients with hepatocellular carcinoma after curative resection
The prevention of recurrence for patients with hepatocellular carcinoma after curative resection is still a great challenge in clinical practice. There are numerous studies that trying to search for favorable ...
Source: BMC Gastroenterology - September 20, 2023 Category: Gastroenterology Authors: Yanyan Ye, Ying Wang, Haoqian Xu and Fengming Yi Tags: Research Source Type: research
TACE Combined with Lenvatinib and Camrelizumab for Unresectable Multiple Nodular and Large Hepatocellular Carcinoma ( & gt;5 cm)
CONCLUSIONS: In patients with unresectable multiple nodular and large HCC (single nodular diameter of >5 cm), TACE combined with target therapy and immunotherapy is safe and effective.PMID:37723998 | DOI:10.1177/15330338231200320
Source: Technology in Cancer Research and Treatment - September 19, 2023 Category: Cancer & Oncology Authors: Zhanwang Xiang Guohong Li Luwen Mu Haofan Wang Churen Zhou Huzheng Yan Mingsheng Huang Source Type: research
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
Cell Res. 2023 Sep 19. doi: 10.1038/s41422-023-00874-4. Online ahead of print.ABSTRACTGlycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism. However, whether glycolytic metabolites also play a role in controlling cell fate remains unexplored. Here, we find that low levels of glycolytic metabolite 3-phosphoglycerate (3-PGA) can switch phosphoglycerate dehydrogenase (PHGDH) from cataplerosis serine synthesis to pro-apoptotic activation of p53. PHGDH is a p53-binding protein, and when unoccupied by 3-PGA interacts with the scaffold pro...
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Yu-Qing Wu Chen-Song Zhang Jinye Xiong Dong-Qi Cai Chen-Zhe Wang Yu Wang Yan-Hui Liu Yu Wang Yiming Li Jian Wu Jianfeng Wu Bin Lan Xuefeng Wang Siwei Chen Xianglei Cao Xiaoyan Wei Hui-Hui Hu Huiling Guo Yaxin Yu Abdul Ghafoor Changchuan Xie Yaying Wu Zhen Source Type: research
Comparative Analysis of First-Line FOLFOX Treatment With and Without Anti-VEGF Therapy in Metastatic Colorectal Carcinoma: A Real-World Data Study
CONCLUSION: Our real-world data analysis suggests that the addition of anti-VEGF to FOLFOX offers limited and short-lived benefits in the context of mCRC and may provide differential survival benefit based on tumor sidedness.PMID:37724508 | DOI:10.1177/10732748231202470
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Ronen Brenner Shlomit Amar-Farkash Avital Klein-Brill Keren Rosenberg-Katz Dvir Aran Source Type: research
Efficacy of TACE Combined with Lenvatinib Plus Sintilimab for Hepatocellular Carcinoma with Tumor Thrombus in the Inferior Vena Cava and/or Right Atrium
CONCLUSION: TACE combination with lenvatinib plus sintilimab is effective in treating HCC with IVC and/or RA TT. The toxicities were manageable, with no unexpected safety signals. The baseline levels of serum PCT might be the predictive biomarkers for the triple combination therapy.PMID:37724186 | PMC:PMC10505388 | DOI:10.2147/JHC.S410967
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Shangkun Ning Xinge Li Xiangyu Ma Jibing Liu Xu Chang Source Type: research
Targeting PTBP1 blocks glutamine metabolism to improve the cisplatin sensitivity of hepatocarcinoma cells through modulating the mRNA stability of glutaminase
Open Med (Wars). 2023 Sep 12;18(1):20230756. doi: 10.1515/med-2023-0756. eCollection 2023.ABSTRACTHepatocellular carcinoma (HCC) is a frequently diagnosed malignancy with a high mortality rate. Cisplatin (CDDP) is a widely applied anti-cancer drug. However, a large population of liver cancer patients developed CDDP resistance. The polypyrimidine tract binding protein (PTBP1) is an RNA-binding protein involving in progressions of diverse cancers. Here we report PTBP1 was significantly upregulated in liver tumors and cell lines. Silencing PTBP1 effectively sensitized HCC cells to CDDP. From the established CDDP-resistant HCC...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Ruimin Tian Yanfei Li Xiaojie Shen Ying Li Source Type: research
