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Specialty: Genetics & Stem Cells
Therapy: Stem Cell Therapy

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Total 34 results found since Jan 2013.

Mechanosensitive Piezo1 Channel in Physiology and Pathophysiology of the Central Nervous System
Ageing Res Rev. 2023 Jul 31:102026. doi: 10.1016/j.arr.2023.102026. Online ahead of print.ABSTRACTSince the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a significant amount of research conducted to explore its regulatory role in the physiology and pathology of various organ systems. Recently, a growing body of compelling evidence has emerged linking the activity of the mechanosensitive Piezo1 channel to health and disease of the central nervous system. However, the exact mechanisms underlying these associations remain inadequately comprehended. This review systematically summarizes the current ...
Source: Ageing Research Reviews - August 2, 2023 Category: Genetics & Stem Cells Authors: Boyi Zong Fengzhi Yu Xiaoyou Zhang Yige Pang Wenrui Zhao Peng Sun Lin Li Source Type: research

Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system
Ageing Res Rev. 2023 Jul 31;90:102026. doi: 10.1016/j.arr.2023.102026. Online ahead of print.ABSTRACTSince the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a significant amount of research conducted to explore its regulatory role in the physiology and pathology of various organ systems. Recently, a growing body of compelling evidence has emerged linking the activity of the mechanosensitive Piezo1 channel to health and disease of the central nervous system. However, the exact mechanisms underlying these associations remain inadequately comprehended. This review systematically summarizes the curre...
Source: Ageing Research Reviews - August 2, 2023 Category: Genetics & Stem Cells Authors: Boyi Zong Fengzhi Yu Xiaoyou Zhang Yige Pang Wenrui Zhao Peng Sun Lin Li Source Type: research

Mechanosensitive Piezo1 Channel in Physiology and Pathophysiology of the Central Nervous System
Ageing Res Rev. 2023 Jul 31:102026. doi: 10.1016/j.arr.2023.102026. Online ahead of print.ABSTRACTSince the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a significant amount of research conducted to explore its regulatory role in the physiology and pathology of various organ systems. Recently, a growing body of compelling evidence has emerged linking the activity of the mechanosensitive Piezo1 channel to health and disease of the central nervous system. However, the exact mechanisms underlying these associations remain inadequately comprehended. This review systematically summarizes the current ...
Source: Ageing Research Reviews - August 2, 2023 Category: Genetics & Stem Cells Authors: Boyi Zong Fengzhi Yu Xiaoyou Zhang Yige Pang Wenrui Zhao Peng Sun Lin Li Source Type: research

GSE208008 Effects of extracellular vehicles secreted from human-induced pluripotent stem cell-derived mesenchymal stem cells on the functional recovery of an ischemic stroke mouse model
Contributors : Xianwei Su ; Gang LuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the the expression profile and potential pathways involved in celluar ischemic stroke model, we established murine HT22 cell lines with oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro
Source: GEO: Gene Expression Omnibus - December 31, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE197199 Genome-wide analysis of gene expression in brain of Neil3-deficient Alzheimer's disease mouse model
Contributors : Milena A Egiazarian ; Silje St ømstad ; Teri Sakshaug ; Ana B Nescolarde ; Nicole Bethge ; Magnar Bjørås ; Katja SchefflerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOxidative stress generating DNA damage has been shown to be a key characteristic in Alzheimer ’s disease (AD). However, how it affects the pathogenesis of AD is not yet fully understood. NEIL3 is a DNA glycosylase initiating oxidative DNA repair and with a distinct expression pattern in proliferating cells. In brain, its function has been linked to hippocampal-dependent memory and to induc tion of ...
Source: GEO: Gene Expression Omnibus - November 15, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Genes, Vol. 13, Pages 1664: Expression Profile of New Gene Markers Involved in Differentiation of Canine Adipose-Derived Stem Cells into Chondrocytes
artosz Kempisty The interest in stem cell research continuously increased over the last decades, becoming one of the most important trends in the 21st century medicine. Stem cell-based therapies have a potential to become a solution for a range of currently untreatable diseases, such as spinal cord injuries, type I diabetes, Parkinson’s disease, heart disease, stroke, and osteoarthritis. Hence, this study, based on canine material, aims to investigate the molecular basis of adipose-derived stem cell (ASC) differentiation into chondrocytes, to serve as a transcriptomic reference for further research aiming...
Source: Genes - September 16, 2022 Category: Genetics & Stem Cells Authors: Maurycy Jankowski Mariusz Kaczmarek Grzegorz W ąsiatycz Aneta Konwerska Claudia Dompe Dorota Bukowska Pawe ł Antosik Paul Mozdziak Bartosz Kempisty Tags: Article Source Type: research

Variable Clinical Features in a Large Family With Diamond Blackfan Anemia Caused by a Pathogenic Missense Mutation in RPS19
Discussion: This large family with DBA demonstrates the heterogeneity of phenotypes that can be seen within the same genotype. Most family members presented with steroid-responsive anemia in infancy and subtle congenital malformations, findings consistent with recent genotype-phenotype studies of RPS DBA. However, two family members were relatively unaffected, underscoring the importance of further studies to assess modifier genes, and epigenetic and/or environmental factors which may result in normal erythropoiesis despite underlying ribosome dysfunction. This large, multigenerational family highlights the need for indivi...
Source: Frontiers in Genetics - July 18, 2022 Category: Genetics & Stem Cells Source Type: research

GSE178936 Longitudinal dynamics of clonal haematopoiesis identifies gene-specific fitness effects
Contributors : Neil A Robertson ; Eric Latorre-Crespo ; Maria Terradas-Terradas ; Linus J Schumacher ; Kristina Kirschner ; Tamir ChandraSeries Type : OtherOrganism : Homo sapiensThe prevalence of clonal haematopoiesis of indeterminate potential (CHIP) in healthy individuals increases rapidly from age 60 onwards and has been associated with increased risk for malignancy, heart disease and ischemic stroke. CHIP is driven by somatic mutations in stem cells that are also drivers of myeloid malignancies. Since mutations in stem cells often drive leukaemia, we hypothesised that stem cell fitness substantially contributes to tra...
Source: GEO: Gene Expression Omnibus - May 3, 2022 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research

GSE195617 Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies
In this study, we used human induced pluripotent stem cell (hiPSC)-derived embryoid bodies (EB) as an in vitro model to investigate the embryotoxic effects of a carefully selected set of pharmacological compounds. Morphology, viability, and differentiation potential were investigated after exposing EBs to folic acid, all-trans-retinoic acid, dexamethasone, and valproic acid for 15 days. The results showed that the compounds differentially repressed cell growth, compromised morphology, and triggered apoptosis in the EBs. Further, transcriptomics was employed to compare subtle temporal changes between treated and untreated c...
Source: GEO: Gene Expression Omnibus - January 31, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Understanding neural stem cell regulation < em > in vivo < /em > and applying the insights to cell therapy for strokes
Regen Med. 2021 Sep;16(9):861-870. doi: 10.2217/rme-2021-0022. Epub 2021 Sep 9.ABSTRACTThe use of neural stem cell (NSC) therapy for the treatment of stroke patients is successfully paving its way into advanced phases of large-scale clinical trials. To understand how to optimize NSC therapeutic approaches, it is fundamental to decipher the crosstalk between NSC and other cells that comprise the NSC microenvironment (niche) and regulate their function, in vivo; namely, the endothelial cells of the microvasculature. In this mini review, we first provide a concise summary of preclinical findings describing the signaling mecha...
Source: Regenerative Medicine - September 9, 2021 Category: Genetics & Stem Cells Authors: Nafiisha Genet Karen K Hirschi Source Type: research

Coding and non-coding nucleotides': The future of stroke gene therapeutics
Genomics. 2021 Mar 4:S0888-7543(21)00084-7. doi: 10.1016/j.ygeno.2021.03.003. Online ahead of print.ABSTRACTStroke is the foremost cause of death ranked after heart disease and cancer. It is the fatal life-threatening event that requires immediate medical admissions to overcome following morbidity and mortality. The therapeutic advances in stroke therapy have been manipulated with diverse paths for last 5 years. Recent research and clinical trials have investigated a variety of anti-stroke agents including anti-coagulants, cerebro-protective agents, antiplatelet therapy, stem-cell therapy, and specified gene therapy. In re...
Source: Genomics - March 7, 2021 Category: Genetics & Stem Cells Authors: Vishal Chavda Kajal Madhwani Source Type: research