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Specialty: Genetics & Stem Cells
Therapy: Stem Cell Therapy

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Total 34 results found since Jan 2013.

Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled degeneration of the central nervous and vascular systems in stroke.
Abstract Stem cell-based treatments have been suggested as promising candidates for stroke. Recently, mesenchymal stem cells (MSCs) have been reported as potential therapeutics for a wide range of diseases. In particular, clinical trial studies have suggested MSCs for stroke therapy. The focus of MSC treatments has been directed towards cell replacement. However, recent research has lately highlighted their paracrine actions. The secretion of extracellular vesicles (EVs) is offered to be the main therapeutic mechanism of MSC therapy. However, EV-based treatments may provide a wider therapeutic window compared to t...
Source: Ageing Research Reviews - June 17, 2020 Category: Genetics & Stem Cells Authors: Rahmani A, Saleki K, Javanmehr N, Khodaparast J, Saadat P, Nouri HR Tags: Ageing Res Rev Source Type: research

Coding and non-coding nucleotides': The future of stroke gene therapeutics
Genomics. 2021 Mar 4:S0888-7543(21)00084-7. doi: 10.1016/j.ygeno.2021.03.003. Online ahead of print.ABSTRACTStroke is the foremost cause of death ranked after heart disease and cancer. It is the fatal life-threatening event that requires immediate medical admissions to overcome following morbidity and mortality. The therapeutic advances in stroke therapy have been manipulated with diverse paths for last 5 years. Recent research and clinical trials have investigated a variety of anti-stroke agents including anti-coagulants, cerebro-protective agents, antiplatelet therapy, stem-cell therapy, and specified gene therapy. In re...
Source: Genomics - March 7, 2021 Category: Genetics & Stem Cells Authors: Vishal Chavda Kajal Madhwani Source Type: research

Stem cell therapies in age-related neurodegenerative diseases and stroke.
Abstract Aging, a complex process associated with various structural, functional and metabolic changes in the brain, is an important risk factor for neurodegenerative diseases and stroke. These diseases share similar neuropathological changes, such as the formation of misfolded proteins, oxidative stress, loss of neurons and synapses, dysfunction of the neurovascular unit (NVU), reduction of self-repair capacity, and motor and/or cognitive deficiencies. In addition to gray matter dysfunction, the plasticity and repair capacity of white matter also decrease with aging and contribute to neurodegenerative diseases. A...
Source: Ageing Research Reviews - November 18, 2016 Category: Genetics & Stem Cells Authors: Wang Y, Ji X, Leak RK, Chen F, Cao G Tags: Ageing Res Rev Source Type: research

Intravascular cell therapy in stroke: predicting the future trends.
Abstract This short review examines the trends that have taken place during the last two decades in selecting delivery route and cell product in confirmatory preclinical stroke research. If there had been a major change, this might indicate a strategy with a high potential to enter early-phase clinical studies. The retrospective data show that intravenous cell delivery of mesenchymal stem cells remains the most popular approach in experimental research, clearly dominating early phase clinical studies. The advantages and risks of current practices are discussed in the hope that these will improve translational succ...
Source: Regenerative Medicine - December 18, 2018 Category: Genetics & Stem Cells Authors: Cui L, Moisan A, Jolkkonen J Tags: Regen Med Source Type: research

GSE120701 Developmentally controlled expression of Cxcr4 by hematopoietic progenitors allows tracing of monocyte function in stroke
Contributors : Yves Werner ; Elvira MassSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMonocyte-derived and tissue-resident macrophages, such as microglia, belong to independent lineages with distinct functions in steady state. During inflammation, however, changes in phenotypes and transcriptional profiles make it difficult to assess their respective roles in pathology. Here, we report that developmentally controlled expression of Cxcr4 by hematopoietic progenitors allows highly specific inducible lineage tracing of hematopoietic stem cell-derived monocytes during inflammation. In t...
Source: GEO: Gene Expression Omnibus - December 31, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Preliminary Reports of Stereotaxic Stem Cell Transplants in Chronic Stroke Patients
Molecular Therapy 24, 1710 (October 2016). doi:10.1038/mt.2016.186 Author: Cesar V Borlongan
Source: Molecular Therapy - November 6, 2016 Category: Genetics & Stem Cells Authors: Cesar V Borlongan Source Type: research

GSE95853 Metallothionein I as a direct link between therapeutic hematopoietic stem/progenitor cells and cerebral protection in stroke
Conclusions: These studies provide further evidence for HSPCs as a promising therapeutic strategy in promoting repair following cerebral I/RI, potentially via a MT-1 mechanism.
Source: GEO: Gene Expression Omnibus - February 21, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE208008 Effects of extracellular vehicles secreted from human-induced pluripotent stem cell-derived mesenchymal stem cells on the functional recovery of an ischemic stroke mouse model
Contributors : Xianwei Su ; Gang LuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the the expression profile and potential pathways involved in celluar ischemic stroke model, we established murine HT22 cell lines with oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro
Source: GEO: Gene Expression Omnibus - December 31, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

SOD3 overexpression alleviates cerebral ischemia ‐reperfusion injury in rats
ConclusionOur results indicated that MSCs transfected withSOD3 can effectively alleviate cerebral ischemia ‐reperfusion injury in rats.
Source: Molecular Genetics & Genomic Medicine - August 27, 2019 Category: Genetics & Stem Cells Authors: Shuaiqi Sun, Ning Gao, Xiqi Hu, Han Luo, Jun Peng, Ying Xia Tags: ORIGINAL ARTICLE Source Type: research

Endothelial Cell Senescence and Age-Related Vascular Diseases
Publication date: 20 September 2014 Source:Journal of Genetics and Genomics, Volume 41, Issue 9 Author(s): Xiao-Li Tian , Yang Li Advanced age is an independent risk factor for ageing-related complex diseases, such as coronary artery disease, stroke, and hypertension, which are common but life threatening and related to the ageing-associated vascular dysfunction. On the other hand, patients with progeria syndromes suffer from serious atherosclerosis, suggesting that the impaired vascular functions may be critical to organismal ageing, or vice versa. However, it remains largely unknown how vascular cells, particularly end...
Source: Journal of Genetics and Genomics - November 30, 2014 Category: Genetics & Stem Cells Source Type: research

PDE3A mutations cause autosomal dominant hypertension with brachydactyly
Nature Genetics 47, 647 (2015). doi:10.1038/ng.3302 Authors: Philipp G Maass, Atakan Aydin, Friedrich C Luft, Carolin Schächterle, Anja Weise, Sigmar Stricker, Carsten Lindschau, Martin Vaegler, Fatimunnisa Qadri, Hakan R Toka, Herbert Schulz, Peter M Krawitz, Dmitri Parkhomchuk, Jochen Hecht, Irene Hollfinger, Yvette Wefeld-Neuenfeld, Eireen Bartels-Klein, Astrid Mühl, Martin Kann, Herbert Schuster, David Chitayat, Martin G Bialer, Thomas F Wienker, Jürg Ott, Katharina Rittscher, Thomas Liehr, Jens Jordan, Ghislaine Plessis, Jens Tank, Knut Mai, Ramin Naraghi, Russell Hodge, Maxwell Hopp, Lars O Hat...
Source: Nature Genetics - May 11, 2015 Category: Genetics & Stem Cells Authors: Philipp G MaassAtakan AydinFriedrich C LuftCarolin SchächterleAnja WeiseSigmar StrickerCarsten LindschauMartin VaeglerFatimunnisa QadriHakan R TokaHerbert SchulzPeter M KrawitzDmitri ParkhomchukJochen HechtIrene HollfingerYvette Wefeld-NeuenfeldEireen Ba Tags: Letter Source Type: research

GSE82101 Expression data from human iPSC-NPC
Contributor : Hsei-Wei WangSeries Type : Expression profiling by arrayOrganism : Homo sapiensInduced pluripotent stem cell-derived neural progenitor cells (iPSC-NPCs) are a promising source of tailor-made cell therapy for neurological diseases. However, tumorigenicity and immunogenicity are major obstacles to translational use. Here we demonstrate epidural therapeutics of human iPSC-NPC grafts after experimental ischemic stroke to avoid surgical damage and intracerebral teratomas. We found that human iPSC-NPCs co-cultured trans-membranously with rat cortical cells subjected to oxygen-glucose deprivation, compared with huma...
Source: GEO: Gene Expression Omnibus - June 2, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Impact of Intermittent Fasting on Health and Disease Processes.
Abstract Humans in modern societies typically consume food at least three times daily, while laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns often leads to metabolic morbidities (insulin resistance, excessive accumulation of visceral fat, etc.), particularly when associated with a sedentary lifestyle. Because animals, including humans, evolved in environments where food was relatively scarce, they developed numerous adaptations that enabled them to function at a high level, both physically and cognitively, when in a food-deprived/fasted state. Intermittent fasting (IF) enco...
Source: Ageing Research Reviews - October 30, 2016 Category: Genetics & Stem Cells Authors: Mattson MP, Longo VD, Harvie M Tags: Ageing Res Rev Source Type: research