Correcting CRISPR for copy number
Nature Genetics 49, 1674 (2017). doi:10.1038/ng.3994 Authors: John Paul Shen & Trey Ideker The CRISPR–Cas9 system enables global screens of gene function with high sensitivity and specificity, but off-target effects have been reported for CRISPR guide RNAs targeting genes that are amplified at high copy number. A new study describes a computational approach to correct for this copy number effect, increasing the specificity of CRIPSR screens to identify essential genes. (Source: Nature Genetics)
Source: Nature Genetics - November 29, 2017 Category: Genetics & Stem Cells Authors: John Paul Shen Trey Ideker Tags: News and Views Source Type: research

Mismatch repair prefers exons
Nature Genetics 49, 1673 (2017). doi:10.1038/ng.3993 Authors: Dashiell J Massey & Amnon Koren A new analysis of cancer genomes identifies a decrease in the mutation burden of exons, but not introns, as compared to expectation. This difference can be explained by preferential recruitment of the DNA mismatch repair machinery to a protein modification that marks exons. (Source: Nature Genetics)
Source: Nature Genetics - November 29, 2017 Category: Genetics & Stem Cells Authors: Dashiell J Massey Amnon Koren Tags: News and Views Source Type: research

Evolutionary insights from wild vervet genomes
Nature Genetics 49, 1671 (2017). doi:10.1038/ng.3992 Author: Ellen M Leffler A new study reports genome-wide variation in 163 vervet monkeys from across their taxonomic and geographic ranges. The analysis suggests a complex history of admixture and identifies signals of repeated evolutionary selection, some of which may be linked to response to simian immunodeficiency virus. (Source: Nature Genetics)
Source: Nature Genetics - November 29, 2017 Category: Genetics & Stem Cells Authors: Ellen M Leffler Tags: News and Views Source Type: research

The hammer of reason
Nature Genetics 49, 1663 (2017). doi:10.1038/ng.3996 In the motivation, conduct and reporting of science, there is no substitute for reason, and it must prevail whenever scientific methods are used. Similarly, scientific recommendations can only be useful if they meet with rational decision-making. Because people come to decisions from diverse viewpoints and values, listening to the values and views of scientists and non-scientists—while explicitly refraining from debate and persuasion—may point the way to determining when and where scientific ideas are of interest and likely to be adopted. (Source: Nature Genetics)
Source: Nature Genetics - November 29, 2017 Category: Genetics & Stem Cells Tags: Editorial Source Type: research

Bayesian inference of negative and positive selection in human cancers
Nature Genetics 49, 1785 (2017). doi:10.1038/ng.3987 Authors: Donate Weghorn & Shamil Sunyaev Cancer genomics efforts have identified genes and regulatory elements driving cancer development and neoplastic progression. From a microevolution standpoint, these are subject to positive selection. Although elusive in current studies, genes whose wild-type coding sequences are needed for tumor growth are also of key interest. They are expected to experience negative selection and stay intact under pressure of incessant mutation. The detection of significantly mutated (or undermutated) genes is completely confounded by t...
Source: Nature Genetics - November 6, 2017 Category: Genetics & Stem Cells Authors: Donate Weghorn Shamil Sunyaev Tags: Letter Source Type: research

High-throughput annotation of full-length long noncoding RNAs with capture long-read sequencing
Nature Genetics 49, 1731 (2017). doi:10.1038/ng.3988 Authors: Julien Lagarde, Barbara Uszczynska-Ratajczak, Silvia Carbonell, Sílvia Pérez-Lluch, Amaya Abad, Carrie Davis, Thomas R Gingeras, Adam Frankish, Jennifer Harrow, Roderic Guigo & Rory Johnson (Source: Nature Genetics)
Source: Nature Genetics - November 6, 2017 Category: Genetics & Stem Cells Authors: Julien Lagarde Barbara Uszczynska-Ratajczak Silvia Carbonell S í lvia P é rez-Lluch Amaya Abad Carrie Davis Thomas R Gingeras Adam Frankish Jennifer Harrow Roderic Guigo Rory Johnson Tags: Article Source Type: research

Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers
Nature Genetics 49, 1693 (2017). doi:10.1038/ng.3990 Authors: Collin M Blakely, Thomas B K Watkins, Wei Wu, Beatrice Gini, Jacob J Chabon, Caroline E McCoach, Nicholas McGranahan, Gareth A Wilson, Nicolai J Birkbak, Victor R Olivas, Julia Rotow, Ashley Maynard, Victoria Wang, Matthew A Gubens, Kimberly C Banks, Richard B Lanman, Aleah F Caulin, John St John, Anibal R Cordero, Petros Giannikopoulos, Andrew D Simmons, Philip C Mack, David R Gandara, Hatim Husain, Robert C Doebele, Jonathan W Riess, Maximilian Diehn, Charles Swanton & Trever G Bivona (Source: Nature Genetics)
Source: Nature Genetics - November 6, 2017 Category: Genetics & Stem Cells Authors: Collin M Blakely Thomas B K Watkins Wei Wu Beatrice Gini Jacob J Chabon Caroline E McCoach Nicholas McGranahan Gareth A Wilson Nicolai J Birkbak Victor R Olivas Julia Rotow Ashley Maynard Victoria Wang Matthew A Gubens Kimberly C Banks Richard B Lanman Al Tags: Article Source Type: research

Reduced mutation rate in exons due to differential mismatch repair
Nature Genetics 49, 1684 (2017). doi:10.1038/ng.3991 Authors: Joan Frigola, Radhakrishnan Sabarinathan, Loris Mularoni, Ferran Muiños, Abel Gonzalez-Perez & Núria López-Bigas (Source: Nature Genetics)
Source: Nature Genetics - November 6, 2017 Category: Genetics & Stem Cells Authors: Joan Frigola Radhakrishnan Sabarinathan Loris Mularoni Ferran Mui ñ os Abel Gonzalez-Perez N ú ria L ó pez-Bigas Tags: Analysis Source Type: research

Computational correction of copy number effect improves specificity of CRISPR – Cas9 essentiality screens in cancer cells
Nature Genetics 49, 1779 (2017). doi:10.1038/ng.3984 Authors: Robin M Meyers, Jordan G Bryan, James M McFarland, Barbara A Weir, Ann E Sizemore, Han Xu, Neekesh V Dharia, Phillip G Montgomery, Glenn S Cowley, Sasha Pantel, Amy Goodale, Yenarae Lee, Levi D Ali, Guozhi Jiang, Rakela Lubonja, William F Harrington, Matthew Strickland, Ting Wu, Derek C Hawes, Victor A Zhivich, Meghan R Wyatt, Zohra Kalani, Jaime J Chang, Michael Okamoto, Kimberly Stegmaier, Todd R Golub, Jesse S Boehm, Francisca Vazquez, David E Root, William C Hahn & Aviad Tsherniak The CRISPR–Cas9 system has revolutionized gene editing both at ...
Source: Nature Genetics - October 30, 2017 Category: Genetics & Stem Cells Authors: Robin M Meyers Jordan G Bryan James M McFarland Barbara A Weir Ann E Sizemore Han Xu Neekesh V Dharia Phillip G Montgomery Glenn S Cowley Sasha Pantel Amy Goodale Yenarae Lee Levi D Ali Guozhi Jiang Rakela Lubonja William F Harrington Matthew Strickland T Tags: Letter Source Type: research

Exome-wide association study of plasma lipids in > 300,000 individuals
Nature Genetics 49, 1758 (2017). doi:10.1038/ng.3977 Authors: Dajiang J Liu, Gina M Peloso, Haojie Yu, Adam S Butterworth, Xiao Wang, Anubha Mahajan, Danish Saleheen, Connor Emdin, Dewan Alam, Alexessander Couto Alves, Philippe Amouyel, Emanuele Di Angelantonio, Dominique Arveiler, Themistocles L Assimes, Paul L Auer, Usman Baber, Christie M Ballantyne, Lia E Bang, Marianne Benn, Joshua C Bis, Michael Boehnke, Eric Boerwinkle, Jette Bork-Jensen, Erwin P Bottinger, Ivan Brandslund, Morris Brown, Fabio Busonero, Mark J Caulfield, John C Chambers, Daniel I Chasman, Y Eugene Chen, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer...
Source: Nature Genetics - October 30, 2017 Category: Genetics & Stem Cells Authors: Dajiang J Liu Gina M Peloso Haojie Yu Adam S Butterworth Xiao Wang Anubha Mahajan Danish Saleheen Connor Emdin Dewan Alam Alexessander Couto Alves Philippe Amouyel Emanuele Di Angelantonio Dominique Arveiler Themistocles L Assimes Paul L Auer Usman Baber Tags: Letter Source Type: research

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
Nature Genetics 49, 1752 (2017). doi:10.1038/ng.3985 Authors: Manuel A Ferreira, Judith M Vonk, Hansjörg Baurecht, Ingo Marenholz, Chao Tian, Joshua D Hoffman, Quinta Helmer, Annika Tillander, Vilhelmina Ullemar, Jenny van Dongen, Yi Lu, Franz Rüschendorf, Jorge Esparza-Gordillo, Chris W Medway, Edward Mountjoy, Kimberley Burrows, Oliver Hummel, Sarah Grosche, Ben M Brumpton, John S Witte, Jouke-Jan Hottenga, Gonneke Willemsen, Jie Zheng, Elke Rodríguez, Melanie Hotze, Andre Franke, Joana A Revez, Jonathan Beesley, Melanie C Matheson, Shyamali C Dharmage, Lisa M Bain, Lars G Fritsche, Maiken E Gabriel...
Source: Nature Genetics - October 30, 2017 Category: Genetics & Stem Cells Authors: Manuel A Ferreira Judith M Vonk Hansj ö rg Baurecht Ingo Marenholz Chao Tian Joshua D Hoffman Quinta Helmer Annika Tillander Vilhelmina Ullemar Jenny van Dongen Yi Lu Franz R ü schendorf Jorge Esparza-Gordillo Chris W Medway Edward Mountjoy Kimberley Bu Tags: Letter Source Type: research

Exome chip meta-analysis identifies novel loci and East Asian – specific coding variants that contribute to lipid levels and coronary artery disease
Nature Genetics 49, 1722 (2017). doi:10.1038/ng.3978 Authors: Xiangfeng Lu, Gina M Peloso, Dajiang J Liu, Ying Wu, He Zhang, Wei Zhou, Jun Li, Clara Sze-man Tang, Rajkumar Dorajoo, Huaixing Li, Jirong Long, Xiuqing Guo, Ming Xu, Cassandra N Spracklen, Yang Chen, Xuezhen Liu, Yan Zhang, Chiea Chuen Khor, Jianjun Liu, Liang Sun, Laiyuan Wang, Yu-Tang Gao, Yao Hu, Kuai Yu, Yiqin Wang, Chloe Yu Yan Cheung, Feijie Wang, Jianfeng Huang, Qiao Fan, Qiuyin Cai, Shufeng Chen, Jinxiu Shi, Xueli Yang, Wanting Zhao, Wayne H-H Sheu, Stacey Shawn Cherny, Meian He, Alan B Feranil, Linda S Adair, Penny Gordon-Larsen, Shufa Du, Rohit V...
Source: Nature Genetics - October 30, 2017 Category: Genetics & Stem Cells Authors: Xiangfeng Lu Gina M Peloso Dajiang J Liu Ying Wu He Zhang Wei Zhou Jun Li Clara Sze-man Tang Rajkumar Dorajoo Huaixing Li Jirong Long Xiuqing Guo Ming Xu Cassandra N Spracklen Yang Chen Xuezhen Liu Yan Zhang Chiea Chuen Khor Jianjun Liu Liang Sun Laiyuan Tags: Article Source Type: research

Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate
Nature Genetics 49, 1714 (2017). doi:10.1038/ng.3959 Authors: Anna J Jasinska, Ivette Zelaya, Susan K Service, Christine B Peterson, Rita M Cantor, Oi-Wa Choi, Joseph DeYoung, Eleazar Eskin, Lynn A Fairbanks, Scott Fears, Allison E Furterer, Yu S Huang, Vasily Ramensky, Christopher A Schmitt, Hannes Svardal, Matthew J Jorgensen, Jay R Kaplan, Diego Villar, Bronwen L Aken, Paul Flicek, Rishi Nag, Emily S Wong, John Blangero, Thomas D Dyer, Marina Bogomolov, Yoav Benjamini, George M Weinstock, Ken Dewar, Chiara Sabatti, Richard K Wilson, J David Jentsch, Wesley Warren, Giovanni Coppola, Roger P Woods & Nelson B Frei...
Source: Nature Genetics - October 30, 2017 Category: Genetics & Stem Cells Authors: Anna J Jasinska Ivette Zelaya Susan K Service Christine B Peterson Rita M Cantor Oi-Wa Choi Joseph DeYoung Eleazar Eskin Lynn A Fairbanks Scott Fears Allison E Furterer Yu S Huang Vasily Ramensky Christopher A Schmitt Hannes Svardal Matthew J Jorgensen Ja Tags: Article Source Type: research

Ancient hybridization and strong adaptation to viruses across African vervet monkey populations
Nature Genetics 49, 1705 (2017). doi:10.1038/ng.3980 Authors: Hannes Svardal, Anna J Jasinska, Cristian Apetrei, Giovanni Coppola, Yu Huang, Christopher A Schmitt, Beatrice Jacquelin, Vasily Ramensky, Michaela Müller-Trutwin, Martin Antonio, George Weinstock, J Paul Grobler, Ken Dewar, Richard K Wilson, Trudy R Turner, Wesley C Warren, Nelson B Freimer & Magnus Nordborg (Source: Nature Genetics)
Source: Nature Genetics - October 30, 2017 Category: Genetics & Stem Cells Authors: Hannes Svardal Anna J Jasinska Cristian Apetrei Giovanni Coppola Yu Huang Christopher A Schmitt Beatrice Jacquelin Vasily Ramensky Michaela M ü ller-Trutwin Martin Antonio George Weinstock J Paul Grobler Ken Dewar Richard K Wilson Trudy R Turner Wesley C Tags: Article Source Type: research

Corrigendum: Germline hypomorphic CARD11 mutations in severe atopic disease
Nature Genetics 49, 1661 (2017). doi:10.1038/ng1117-1661b Author: Chi A Ma, Jeffrey R Stinson, Yuan Zhang, Jordan K Abbott, Michael A Weinreich, Pia J Hauk, Paul R Reynolds, Jonathan J Lyons, Celeste G Nelson, Elisa Ruffo, Batsukh Dorjbal, Salomé Glauzy, Natsuko Yamakawa, Swadhinya Arjunaraja, Kelsey Voss, Jennifer Stoddard, Julie Niemela, Yu Zhang, Sergio D Rosenzweig, Joshua J McElwee, Thomas DiMaggio, Helen F Matthews, Nina Jones, Kelly D Stone, Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti, Brian Kim, Megan A Coop...
Source: Nature Genetics - October 27, 2017 Category: Genetics & Stem Cells Authors: Chi A Ma Jeffrey R Stinson Yuan Zhang Jordan K Abbott Michael A Weinreich Pia J Hauk Paul R Reynolds Jonathan J Lyons Celeste G Nelson Elisa Ruffo Batsukh Dorjbal Salom é Glauzy Natsuko Yamakawa Swadhinya Arjunaraja Kelsey Voss Jennifer Stoddard Julie N Tags: Corrigendum Source Type: research

Corrigendum: A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers
Nature Genetics 49, 1661 (2017). doi:10.1038/ng1117-1661a Author: Dominik Glodzik, Sandro Morganella, Helen Davies, Peter T Simpson, Yilong Li, Xueqing Zou, Javier Diez-Perez, Johan Staaf, Ludmil B Alexandrov, Marcel Smid, Arie B Brinkman, Inga Hansine Rye, Hege Russnes, Keiran Raine, Colin A Purdie, Sunil R Lakhani, Alastair M Thompson, Ewan Birney, Hendrik G Stunnenberg, Marc J van de Vijver, John W M Martens, Anne-Lise Børresen-Dale, Andrea L Richardson, Gu Kong, Alain Viari, Douglas Easton, Gerard Evan, Peter J Campbell, Michael R Stratton & Serena Nik-Zainal (Source: Nature Genetics)
Source: Nature Genetics - October 27, 2017 Category: Genetics & Stem Cells Authors: Dominik Glodzik Sandro Morganella Helen Davies Peter T Simpson Yilong Li Xueqing Zou Javier Diez-Perez Johan Staaf Ludmil B Alexandrov Marcel Smid Arie B Brinkman Inga Hansine Rye Hege Russnes Keiran Raine Colin A Purdie Sunil R Lakhani Alastair M Thompso Tags: Corrigendum Source Type: research

Erratum: DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats
Nature Genetics 49, 1661 (2017). doi:10.1038/ng1117-1661c Author: David Brocks, Christopher R Schmidt, Michael Daskalakis, Hyo Sik Jang, Nakul M Shah, Daofeng Li, Jing Li, Bo Zhang, Yiran Hou, Sara Laudato, Daniel B Lipka, Johanna Schott, Holger Bierhoff, Yassen Assenov, Monika Helf, Alzbeta Ressnerova, Md Saiful Islam, Anders M Lindroth, Simon Haas, Marieke Essers, Charles D Imbusch, Benedikt Brors, Ina Oehme, Olaf Witt, Michael Lübbert, Jan-Philipp Mallm, Karsten Rippe, Rainer Will, Dieter Weichenhan, Georg Stoecklin, Clarissa Gerhäuser, Christopher C Oakes, Ting Wang & Christoph Plass (Source: Nature Genetics)
Source: Nature Genetics - October 27, 2017 Category: Genetics & Stem Cells Authors: David Brocks Christopher R Schmidt Michael Daskalakis Hyo Sik Jang Nakul M Shah Daofeng Li Jing Li Bo Zhang Yiran Hou Sara Laudato Daniel B Lipka Johanna Schott Holger Bierhoff Yassen Assenov Monika Helf Alzbeta Ressnerova Md Saiful Islam Anders M Lindrot Tags: Erratum Source Type: research

Divergent evolutionary trajectories in transplanted tumor models
Nature Genetics 49, 1565 (2017). doi:10.1038/ng.3983 Authors: Carlos Villacorta-Martin, Amanda J Craig & Augusto Villanueva Human-derived tumor models are becoming popular in the context of personalized medicine, but a new study shows that these models could be less representative of primary tumors than previously thought, particularly when using late passages. (Source: Nature Genetics)
Source: Nature Genetics - October 27, 2017 Category: Genetics & Stem Cells Authors: Carlos Villacorta-Martin Amanda J Craig Augusto Villanueva Tags: News and Views Source Type: research

Enhancers looping to target genes
Nature Genetics 49, 1564 (2017). doi:10.1038/ng.3982 Author: Gosia Trynka High-resolution maps of enhancer–promoter interactions in rare primary human T cell subsets and coronary artery smooth muscle cells link variants associated with autoimmune and cardiovascular diseases to target genes. This represents an important step forward for mapping genes involved in complex diseases. (Source: Nature Genetics)
Source: Nature Genetics - October 27, 2017 Category: Genetics & Stem Cells Authors: Gosia Trynka Tags: News and Views Source Type: research

Analysis commons, a team approach to discovery in a big-data environment for genetic epidemiology
Nature Genetics 49, 1560 (2017). doi:10.1038/ng.3968 Authors: Jennifer A Brody, Alanna C Morrison, Joshua C Bis, Jeffrey R O'Connell, Michael R Brown, Jennifer E Huffman, Darren C Ames, Andrew Carroll, Matthew P Conomos, Stacey Gabriel, Richard A Gibbs, Stephanie M Gogarten, Namrata Gupta, Cashell E Jaquish, Andrew D Johnson, Joshua P Lewis, Xiaoming Liu, Alisa K Manning, George J Papanicolaou, Achilleas N Pitsillides, Kenneth M Rice, William Salerno, Colleen M Sitlani, Nicholas L Smith, Susan R Heckbert, Cathy C Laurie, Braxton D Mitchell, Ramachandran S Vasan, Stephen S Rich, Jerome I Rotter, James G Wilson, Eric Bo...
Source: Nature Genetics - October 27, 2017 Category: Genetics & Stem Cells Authors: Jennifer A Brody Alanna C Morrison Joshua C Bis Jeffrey R O'Connell Michael R Brown Jennifer E Huffman Darren C Ames Andrew Carroll Matthew P Conomos Stacey Gabriel Richard A Gibbs Stephanie M Gogarten Namrata Gupta Cashell E Jaquish Andrew D Johnson Josh Tags: Commentary Source Type: research

Neutral citation is poor scholarship
Nature Genetics 49, 1559 (2017). doi:10.1038/ng.3989 Citation of prior publications is essential both to claim that knowledge is needed in your area of research and to establish that you have indeed advanced understanding substantially in that area. The journal deplores and will decline to consider manuscripts that fail to identify the key findings of published articles and that—deliberately or inadvertently—omit the reason the prior work is cited. (Source: Nature Genetics)
Source: Nature Genetics - October 27, 2017 Category: Genetics & Stem Cells Tags: Editorial Source Type: research

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
Nature Genetics 49, 1767 (2017). doi:10.1038/ng.3785 Authors: Roger L Milne, Karoline B Kuchenbaecker, Kyriaki Michailidou, Jonathan Beesley, Siddhartha Kar, Sara Lindström, Shirley Hui, Audrey Lemaçon, Penny Soucy, Joe Dennis, Xia Jiang, Asha Rostamianfar, Hilary Finucane, Manjeet K Bolla, Lesley McGuffog, Qin Wang, Cora M Aalfs, Marcia Adams, Julian Adlard, Simona Agata, Shahana Ahmed, Habibul Ahsan, Kristiina Aittomäki, Fares Al-Ejeh, Jamie Allen, Christine B Ambrosone, Christopher I Amos, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Norbert Arnold, Kristan J Aronson, B...
Source: Nature Genetics - October 23, 2017 Category: Genetics & Stem Cells Authors: Roger L Milne Karoline B Kuchenbaecker Kyriaki Michailidou Jonathan Beesley Siddhartha Kar Sara Lindstr ö m Shirley Hui Audrey Lema ç on Penny Soucy Joe Dennis Xia Jiang Asha Rostamianfar Hilary Finucane Manjeet K Bolla Lesley McGuffog Qin Wang Cora M A Tags: Letter Source Type: research

Predicting causal variants affecting expression by using whole-genome sequencing and RNA-seq from multiple human tissues
Nature Genetics 49, 1747 (2017). doi:10.1038/ng.3979 Authors: Andrew Anand Brown, Ana Viñuela, Olivier Delaneau, Tim D Spector, Kerrin S Small & Emmanouil T Dermitzakis Genetic association mapping produces statistical links between phenotypes and genomic regions, but identifying causal variants remains difficult. Whole-genome sequencing (WGS) can help by providing complete knowledge of all genetic variants, but it is financially prohibitive for well-powered GWAS studies. We performed mapping of expression quantitative trait loci (eQTLs) with WGS and RNA-seq, and found that lead eQTL variants called with WGS...
Source: Nature Genetics - October 23, 2017 Category: Genetics & Stem Cells Authors: Andrew Anand Brown Ana Vi ñ uela Olivier Delaneau Tim D Spector Kerrin S Small Emmanouil T Dermitzakis Tags: Letter Source Type: research

Estimating the causal tissues for complex traits and diseases
Nature Genetics 49, 1676 (2017). doi:10.1038/ng.3981 Authors: Halit Ongen, Andrew A Brown, Olivier Delaneau, Nikolaos I Panousis, Alexandra C Nica & Emmanouil T Dermitzakis (Source: Nature Genetics)
Source: Nature Genetics - October 23, 2017 Category: Genetics & Stem Cells Authors: Halit Ongen Andrew A Brown Olivier Delaneau Nikolaos I Panousis Alexandra C Nica Emmanouil T Dermitzakis Tags: Analysis Source Type: research

Covariate selection for association screening in multiphenotype genetic studies
Nature Genetics 49, 1789 (2017). doi:10.1038/ng.3975 Authors: Hugues Aschard, Vincent Guillemot, Bjarni Vilhjalmsson, Chirag J Patel, David Skurnik, Chun J Ye, Brian Wolpin, Peter Kraft & Noah Zaitlen (Source: Nature Genetics)
Source: Nature Genetics - October 16, 2017 Category: Genetics & Stem Cells Authors: Hugues Aschard Vincent Guillemot Bjarni Vilhjalmsson Chirag J Patel David Skurnik Chun J Ye Brian Wolpin Peter Kraft Noah Zaitlen Tags: Technical Report Source Type: research

A quantitative genetic framework highlights the role of epistatic effects for grain-yield heterosis in bread wheat
Nature Genetics 49, 1741 (2017). doi:10.1038/ng.3974 Authors: Yong Jiang, Renate H Schmidt, Yusheng Zhao & Jochen C Reif (Source: Nature Genetics)
Source: Nature Genetics - October 16, 2017 Category: Genetics & Stem Cells Authors: Yong Jiang Renate H Schmidt Yusheng Zhao Jochen C Reif Tags: Article Source Type: research

Enhancing GTEx by bridging the gaps between genotype, gene expression, and disease
Nature Genetics 49, 1664 (2017). doi:10.1038/ng.3969 Authors: Genetic variants have been associated with myriad molecular phenotypes that provide new insight into the range of mechanisms underlying genetic traits and diseases. Identifying any particular genetic variant's cascade of effects, from molecule to individual, requires assaying multiple layers of molecular complexity. We introduce the Enhancing GTEx (eGTEx) project that extends the GTEx project to combine gene expression with additional intermediate molecular measurements on the same tissues to provide a resource for studying how genetic differences cascade ...
Source: Nature Genetics - October 11, 2017 Category: Genetics & Stem Cells Tags: Commentary Source Type: research

The draft genome of tropical fruit durian (Durio zibethinus)
Nature Genetics 49, 1633 (2017). doi:10.1038/ng.3972 Authors: Bin Tean Teh, Kevin Lim, Chern Han Yong, Cedric Chuan Young Ng, Sushma Ramesh Rao, Vikneswari Rajasegaran, Weng Khong Lim, Choon Kiat Ong, Ki Chan, Vincent Kin Yuen Cheng, Poh Sheng Soh, Sanjay Swarup, Steven G Rozen, Niranjan Nagarajan & Patrick Tan (Source: Nature Genetics)
Source: Nature Genetics - October 9, 2017 Category: Genetics & Stem Cells Authors: Bin Tean Teh Kevin Lim Chern Han Yong Cedric Chuan Young Ng Sushma Ramesh Rao Vikneswari Rajasegaran Weng Khong Lim Choon Kiat Ong Ki Chan Vincent Kin Yuen Cheng Poh Sheng Soh Sanjay Swarup Steven G Rozen Niranjan Nagarajan Patrick Tan Tags: Article Source Type: research

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands
Nature Genetics 49, 1593 (2017). doi:10.1038/ng.3970 Authors: Sheng Chih Jin, Jason Homsy, Samir Zaidi, Qiongshi Lu, Sarah Morton, Steven R DePalma, Xue Zeng, Hongjian Qi, Weni Chang, Michael C Sierant, Wei-Chien Hung, Shozeb Haider, Junhui Zhang, James Knight, Robert D Bjornson, Christopher Castaldi, Irina R Tikhonoa, Kaya Bilguvar, Shrikant M Mane, Stephan J Sanders, Seema Mital, Mark W Russell, J William Gaynor, John Deanfield, Alessandro Giardini, George A Porter, Deepak Srivastava, Cecelia W Lo, Yufeng Shen, W Scott Watkins, Mark Yandell, H Joseph Yost, Martin Tristani-Firouzi, Jane W Newburger, Amy E Roberts, Ri...
Source: Nature Genetics - October 9, 2017 Category: Genetics & Stem Cells Authors: Sheng Chih Jin Jason Homsy Samir Zaidi Qiongshi Lu Sarah Morton Steven R DePalma Xue Zeng Hongjian Qi Weni Chang Michael C Sierant Wei-Chien Hung Shozeb Haider Junhui Zhang James Knight Robert D Bjornson Christopher Castaldi Irina R Tikhonoa Kaya Bilguvar Tags: Article Source Type: research

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia
Nature Genetics 49, 1576 (2017). doi:10.1038/ng.3973 Authors: Zhiqiang Li, Jianhua Chen, Hao Yu, Lin He, Yifeng Xu, Dai Zhang, Qizhong Yi, Changgui Li, Xingwang Li, Jiawei Shen, Zhijian Song, Weidong Ji, Meng Wang, Juan Zhou, Boyu Chen, Yahui Liu, Jiqiang Wang, Peng Wang, Ping Yang, Qingzhong Wang, Guoyin Feng, Benxiu Liu, Wensheng Sun, Baojie Li, Guang He, Weidong Li, Chunling Wan, Qi Xu, Wenjin Li, Zujia Wen, Ke Liu, Fang Huang, Jue Ji, Stephan Ripke, Weihua Yue, Patrick F Sullivan, Michael C O'Donovan & Yongyong Shi (Source: Nature Genetics)
Source: Nature Genetics - October 9, 2017 Category: Genetics & Stem Cells Authors: Zhiqiang Li Jianhua Chen Hao Yu Lin He Yifeng Xu Dai Zhang Qizhong Yi Changgui Li Xingwang Li Jiawei Shen Zhijian Song Weidong Ji Meng Wang Juan Zhou Boyu Chen Yahui Liu Jiqiang Wang Peng Wang Ping Yang Qingzhong Wang Guoyin Feng Benxiu Liu Wensheng Sun B Tags: Article Source Type: research

Patient-derived xenografts undergo mouse-specific tumor evolution
Nature Genetics 49, 1567 (2017). doi:10.1038/ng.3967 Authors: Uri Ben-David, Gavin Ha, Yuen-Yi Tseng, Noah F Greenwald, Coyin Oh, Juliann Shih, James M McFarland, Bang Wong, Jesse S Boehm, Rameen Beroukhim & Todd R Golub (Source: Nature Genetics)
Source: Nature Genetics - October 9, 2017 Category: Genetics & Stem Cells Authors: Uri Ben-David Gavin Ha Yuen-Yi Tseng Noah F Greenwald Coyin Oh Juliann Shih James M McFarland Bang Wong Jesse S Boehm Rameen Beroukhim Todd R Golub Tags: Analysis Source Type: research

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability
Nature Genetics 49, 1647 (2017). doi:10.1038/ng.3965 Authors: Ryan Rickels, Hans-Martin Herz, Christie C Sze, Kaixiang Cao, Marc A Morgan, Clayton K Collings, Maria Gause, Yoh-hei Takahashi, Lu Wang, Emily J Rendleman, Stacy A Marshall, Annika Krueger, Elizabeth T Bartom, Andrea Piunti, Edwin R Smith, Nebiyu A Abshiru, Neil L Kelleher, Dale Dorsett & Ali Shilatifard Histone H3 lysine 4 monomethylation (H3K4me1) is an evolutionarily conserved feature of enhancer chromatin catalyzed by the COMPASS-like methyltransferase family, which includes Trr in Drosophila melanogaster and MLL3 (encoded by KMT2C) and MLL4 (encod...
Source: Nature Genetics - October 2, 2017 Category: Genetics & Stem Cells Authors: Ryan Rickels Hans-Martin Herz Christie C Sze Kaixiang Cao Marc A Morgan Clayton K Collings Maria Gause Yoh-hei Takahashi Lu Wang Emily J Rendleman Stacy A Marshall Annika Krueger Elizabeth T Bartom Andrea Piunti Edwin R Smith Nebiyu A Abshiru Neil L Kelle Tags: Letter Source Type: research

Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Nature Genetics 49, 1558 (2017). doi:10.1038/ng1017-1558a Authors: Helen R Warren, Evangelos Evangelou, Claudia P Cabrera, He Gao, Meixia Ren, Borbala Mifsud, Ioanna Ntalla, Praveen Surendran, Chunyu Liu, James P Cook, Aldi T Kraja, Fotios Drenos, Marie Loh, Niek Verweij, Jonathan Marten, Ibrahim Karaman, Marcelo P Segura Lepe, Paul F O'Reilly, Joanne Knight, Harold Snieder, Norihiro Kato, Jiang He, E Shyong Tai, M Abdullah Said, David Porteous, Maris Alver, Neil Poulter, Martin Farrall, Ron T Gansevoort, Sandosh Padmanabhan, Reedik Mägi, Alice Stanton, John Connell, Stephan J L Bakker, Andres Metspalu, Denis C S...
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Authors: Helen R Warren Evangelos Evangelou Claudia P Cabrera He Gao Meixia Ren Borbala Mifsud Ioanna Ntalla Praveen Surendran Chunyu Liu James P Cook Aldi T Kraja Fotios Drenos Marie Loh Niek Verweij Jonathan Marten Ibrahim Karaman Marcelo P Segura Lepe Paul F O' Tags: Corrigendum Source Type: research

Erratum: Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Nature Genetics 49, 1558 (2017). doi:10.1038/ng1017-1558d Author: (Source: Nature Genetics)
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Tags: Erratum Source Type: research

Erratum: Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
Nature Genetics 49, 1558 (2017). doi:10.1038/ng1017-1558c Authors: Suzanne Sniekers, Sven Stringer, Kyoko Watanabe, Philip R Jansen, Jonathan R I Coleman, Eva Krapohl, Erdogan Taskesen, Anke R Hammerschlag, Aysu Okbay, Delilah Zabaneh, Najaf Amin, Gerome Breen, David Cesarini, Christopher F Chabris, William G Iacono, M Arfan Ikram, Magnus Johannesson, Philipp Koellinger, James J Lee, Patrik K E Magnusson, Matt McGue, Mike B Miller, William E R Ollier, Antony Payton, Neil Pendleton, Robert Plomin, Cornelius A Rietveld, Henning Tiemeier, Cornelia M van Duijn & Danielle Posthuma (Source: Nature Genetics)
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Authors: Suzanne Sniekers Sven Stringer Kyoko Watanabe Philip R Jansen Jonathan R I Coleman Eva Krapohl Erdogan Taskesen Anke R Hammerschlag Aysu Okbay Delilah Zabaneh Najaf Amin Gerome Breen David Cesarini Christopher F Chabris William G Iacono M Arfan Ikram Magn Tags: Erratum Source Type: research

Erratum: PGBD5 promotes site-specific oncogenic mutations in human tumors
Nature Genetics 49, 1558 (2017). doi:10.1038/ng1017-1558b Authors: Anton G Henssen, Richard Koche, Jiali Zhuang, Eileen Jiang, Casie Reed, Amy Eisenberg, Eric Still, Ian C MacArthur, Elias Rodríguez-Fos, Santiago Gonzalez, Montserrat Puiggròs, Andrew N Blackford, Christopher E Mason, Elisa de Stanchina, Mithat Gönen, Anne-Katrin Emde, Minita Shah, Kanika Arora, Catherine Reeves, Nicholas D Socci, Elizabeth Perlman, Cristina R Antonescu, Charles W M Roberts, Hanno Steen, Elizabeth Mullen, Stephen P Jackson, David Torrents, Zhiping Weng, Scott A Armstrong & Alex Kentsis (Source: Nature Genetics)
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Authors: Anton G Henssen Richard Koche Jiali Zhuang Eileen Jiang Casie Reed Amy Eisenberg Eric Still Ian C MacArthur Elias Rodr í guez-Fos Santiago Gonzalez Montserrat Puiggr ò s Andrew N Blackford Christopher E Mason Elisa de Stanchina Mithat G ö nen Anne-Katr Tags: Erratum Source Type: research

Capturing condensin in chromosomes
This study provides insight into the mechanism whereby a centimeters-long DNA molecule is folded into a micrometers-long rod-shaped chromosome. (Source: Nature Genetics)
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Authors: Tatsuya Hirano Tags: News and Views Source Type: research

A fine LINE-1 in mouse embryonic chromatin regulation
Nature Genetics 49, 1418 (2017). doi:10.1038/ng.3960 Author: Edward J Grow The functional role of repetitive elements in mammalian genomes is still largely unexplored. A new study provides evidence that LINE-1 retrotransposons regulate chromatin dynamics and are essential for normal embryonic development in mice. (Source: Nature Genetics)
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Authors: Edward J Grow Tags: News and Views Source Type: research

Polycomb silencing mediated by specific DNA-binding recruiters
Nature Genetics 49, 1416 (2017). doi:10.1038/ng.3961 Authors: Eduardo March & Sara Farrona Regulation of epigenetic factors through their recruitment to specific genomic regions is still poorly understood. A recent study demonstrates a global mechanism of tethering Polycomb group (PcG) proteins through sequence-specific DNA-binding factors. (Source: Nature Genetics)
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Authors: Eduardo March Sara Farrona Tags: News and Views Source Type: research

The multidimensional nucleus
Nature Genetics 49, 1415 (2017). doi:10.1038/ng.3971 This issue highlights a range of genetic techniques and cell biological models required to begin to understand the levels of long-range regulation of gene expression as it occurs during cell differentiation. Explanations based on the specificity of covalent modifications and binding interactions intersect with evidence for conjectured mechanisms of topological loop creation and maintenance by transcription and motile protein activities. (Source: Nature Genetics)
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Tags: Editorial Source Type: research

Graphtyper enables population-scale genotyping using pangenome graphs
Nature Genetics 49, 1654 (2017). doi:10.1038/ng.3964 Authors: Hannes P Eggertsson, Hakon Jonsson, Snaedis Kristmundsdottir, Eirikur Hjartarson, Birte Kehr, Gisli Masson, Florian Zink, Kristjan E Hjorleifsson, Aslaug Jonasdottir, Adalbjorg Jonasdottir, Ingileif Jonsdottir, Daniel F Gudbjartsson, Pall Melsted, Kari Stefansson & Bjarni V Halldorsson (Source: Nature Genetics)
Source: Nature Genetics - September 25, 2017 Category: Genetics & Stem Cells Authors: Hannes P Eggertsson Hakon Jonsson Snaedis Kristmundsdottir Eirikur Hjartarson Birte Kehr Gisli Masson Florian Zink Kristjan E Hjorleifsson Aslaug Jonasdottir Adalbjorg Jonasdottir Ingileif Jonsdottir Daniel F Gudbjartsson Pall Melsted Kari Stefansson Bjar Tags: Technical Report Source Type: research

Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma
Nature Genetics 49, 1624 (2017). doi:10.1038/ng.3957 Authors: Phillips Y Huang, Eve Kandyba, Arnaud Jabouille, Jonas Sjolund, Atul Kumar, Kyle Halliwill, Melissa McCreery, Reyno DelRosario, Hio Chung Kang, Christine E Wong, Jost Seibler, Vincent Beuger, Maurizio Pellegrino, Adam Sciambi, Dennis J Eastburn & Allan Balmain (Source: Nature Genetics)
Source: Nature Genetics - September 25, 2017 Category: Genetics & Stem Cells Authors: Phillips Y Huang Eve Kandyba Arnaud Jabouille Jonas Sjolund Atul Kumar Kyle Halliwill Melissa McCreery Reyno DelRosario Hio Chung Kang Christine E Wong Jost Seibler Vincent Beuger Maurizio Pellegrino Adam Sciambi Dennis J Eastburn Allan Balmain Tags: Article Source Type: research

SMARCB1 is required for widespread BAF complex – mediated activation of enhancers and bivalent promoters
Nature Genetics 49, 1613 (2017). doi:10.1038/ng.3958 Authors: Robert T Nakayama, John L Pulice, Alfredo M Valencia, Matthew J McBride, Zachary M McKenzie, Mark A Gillespie, Wai Lim Ku, Mingxiang Teng, Kairong Cui, Robert T Williams, Seth H Cassel, He Qing, Christian J Widmer, George D Demetri, Rafael A Irizarry, Keji Zhao, Jeffrey A Ranish & Cigall Kadoch (Source: Nature Genetics)
Source: Nature Genetics - September 25, 2017 Category: Genetics & Stem Cells Authors: Robert T Nakayama John L Pulice Alfredo M Valencia Matthew J McBride Zachary M McKenzie Mark A Gillespie Wai Lim Ku Mingxiang Teng Kairong Cui Robert T Williams Seth H Cassel He Qing Christian J Widmer George D Demetri Rafael A Irizarry Keji Zhao Jeffrey Tags: Article Source Type: research

Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
Nature Genetics 49, 1602 (2017). doi:10.1038/ng.3963 Authors: Maxwell R Mumbach, Ansuman T Satpathy, Evan A Boyle, Chao Dai, Benjamin G Gowen, Seung Woo Cho, Michelle L Nguyen, Adam J Rubin, Jeffrey M Granja, Katelynn R Kazane, Yuning Wei, Trieu Nguyen, Peyton G Greenside, M Ryan Corces, Josh Tycko, Dimitre R Simeonov, Nabeela Suliman, Rui Li, Jin Xu, Ryan A Flynn, Anshul Kundaje, Paul A Khavari, Alexander Marson, Jacob E Corn, Thomas Quertermous, William J Greenleaf & Howard Y Chang (Source: Nature Genetics)
Source: Nature Genetics - September 25, 2017 Category: Genetics & Stem Cells Authors: Maxwell R Mumbach Ansuman T Satpathy Evan A Boyle Chao Dai Benjamin G Gowen Seung Woo Cho Michelle L Nguyen Adam J Rubin Jeffrey M Granja Katelynn R Kazane Yuning Wei Trieu Nguyen Peyton G Greenside M Ryan Corces Josh Tycko Dimitre R Simeonov Nabeela Suli Tags: Article Source Type: research

Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control
Nature Genetics 49, 1642 (2017). doi:10.1038/ng.3956 Authors: Federico Tessadori, Jacques C Giltay, Jane A Hurst, Maarten P Massink, Karen Duran, Harmjan R Vos, Robert M van Es, Richard H Scott, Koen L I van Gassen, Jeroen Bakkers & Gijs van Haaften Covalent modifications of histones have an established role as chromatin effectors, as they control processes such as DNA replication and transcription, and repair or regulate nucleosomal structure. Loss of modifications on histone N tails, whether due to mutations in genes belonging to histone-modifying complexes or mutations directly affecting the histone tails, caus...
Source: Nature Genetics - September 18, 2017 Category: Genetics & Stem Cells Authors: Federico Tessadori Jacques C Giltay Jane A Hurst Maarten P Massink Karen Duran Harmjan R Vos Robert M van Es Richard H Scott Koen L I van Gassen Jeroen Bakkers Gijs van Haaften Tags: Letter Source Type: research

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
Nature Genetics 49, 1511 (2017). doi:10.1038/ng.3955 Authors: Diana Chang, Mike A Nalls, Ingileif B Hallgrímsdóttir, Julie Hunkapiller, Marcel van der Brug, Fang Cai, Geoffrey A Kerchner, Gai Ayalon, Baris Bingol, Morgan Sheng, David Hinds, Timothy W Behrens, Andrew B Singleton, Tushar R Bhangale & Robert R Graham Common variant genome-wide association studies (GWASs) have, to date, identified>24 risk loci for Parkinson's disease (PD). To discover additional loci, we carried out a GWAS comparing 6,476 PD cases with 302,042 controls, followed by a meta-analysis with a recent study of over 13,000 PD...
Source: Nature Genetics - September 11, 2017 Category: Genetics & Stem Cells Authors: Diana Chang Mike A Nalls Ingileif B Hallgr í msd ó ttir Julie Hunkapiller Marcel van der Brug Fang Cai Geoffrey A Kerchner Gai Ayalon Baris Bingol Morgan Sheng David Hinds Timothy W Behrens Andrew B Singleton Tushar R Bhangale Robert R Graham Tags: Letter Source Type: research

Interpreting short tandem repeat variations in humans using mutational constraint
Nature Genetics 49, 1495 (2017). doi:10.1038/ng.3952 Authors: Melissa Gymrek, Thomas Willems, David Reich & Yaniv Erlich (Source: Nature Genetics)
Source: Nature Genetics - September 11, 2017 Category: Genetics & Stem Cells Authors: Melissa Gymrek Thomas Willems David Reich Yaniv Erlich Tags: Article Source Type: research

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population
Nature Genetics 49, 1458 (2017). doi:10.1038/ng.3951 Authors: Masato Akiyama, Yukinori Okada, Masahiro Kanai, Atsushi Takahashi, Yukihide Momozawa, Masashi Ikeda, Nakao Iwata, Shiro Ikegawa, Makoto Hirata, Koichi Matsuda, Motoki Iwasaki, Taiki Yamaji, Norie Sawada, Tsuyoshi Hachiya, Kozo Tanno, Atsushi Shimizu, Atsushi Hozawa, Naoko Minegishi, Shoichiro Tsugane, Masayuki Yamamoto, Michiaki Kubo & Yoichiro Kamatani (Source: Nature Genetics)
Source: Nature Genetics - September 11, 2017 Category: Genetics & Stem Cells Authors: Masato Akiyama Yukinori Okada Masahiro Kanai Atsushi Takahashi Yukihide Momozawa Masashi Ikeda Nakao Iwata Shiro Ikegawa Makoto Hirata Koichi Matsuda Motoki Iwasaki Taiki Yamaji Norie Sawada Tsuyoshi Hachiya Kozo Tanno Atsushi Shimizu Atsushi Hozawa Naoko Tags: Article Source Type: research

A functional genomics predictive network model identifies regulators of inflammatory bowel disease
Nature Genetics 49, 1437 (2017). doi:10.1038/ng.3947 Authors: Lauren A Peters, Jacqueline Perrigoue, Arthur Mortha, Alina Iuga, Won-min Song, Eric M Neiman, Sean R Llewellyn, Antonio Di Narzo, Brian A Kidd, Shannon E Telesco, Yongzhong Zhao, Aleksandar Stojmirovic, Jocelyn Sendecki, Khader Shameer, Riccardo Miotto, Bojan Losic, Hardik Shah, Eunjee Lee, Minghui Wang, Jeremiah J Faith, Andrew Kasarskis, Carrie Brodmerkel, Mark Curran, Anuk Das, Joshua R Friedman, Yoshinori Fukui, Mary Beth Humphrey, Brian M Iritani, Nicholas Sibinga, Teresa K Tarrant, Carmen Argmann, Ke Hao, Panos Roussos, Jun Zhu, Bin Zhang, Radu Dobri...
Source: Nature Genetics - September 11, 2017 Category: Genetics & Stem Cells Authors: Lauren A Peters Jacqueline Perrigoue Arthur Mortha Alina Iuga Won-min Song Eric M Neiman Sean R Llewellyn Antonio Di Narzo Brian A Kidd Shannon E Telesco Yongzhong Zhao Aleksandar Stojmirovic Jocelyn Sendecki Khader Shameer Riccardo Miotto Bojan Losic Har Tags: Article Source Type: research

Linkage disequilibrium – dependent architecture of human complex traits shows action of negative selection
Nature Genetics 49, 1421 (2017). doi:10.1038/ng.3954 Authors: Steven Gazal, Hilary K Finucane, Nicholas A Furlotte, Po-Ru Loh, Pier Francesco Palamara, Xuanyao Liu, Armin Schoech, Brendan Bulik-Sullivan, Benjamin M Neale, Alexander Gusev & Alkes L Price (Source: Nature Genetics)
Source: Nature Genetics - September 11, 2017 Category: Genetics & Stem Cells Authors: Steven Gazal Hilary K Finucane Nicholas A Furlotte Po-Ru Loh Pier Francesco Palamara Xuanyao Liu Armin Schoech Brendan Bulik-Sullivan Benjamin M Neale Alexander Gusev Alkes L Price Tags: Analysis Source Type: research